Ethan B Jansen, Ali Toloue Ostadgavahi, Benjamin Hewins, Rachelle Buchanan, Brittany M Thivierge, Gustavo Sganzerla Martinez, Una Goncin, Magen E Francis, Cynthia L Swan, Erin Scruten, Jack Bell, Joseph Darbellay, Antonio Facciuolo, Darryl Falzarano, Volker Gerdts, Mark E Fenton, Peter Hedlin, David J Kelvin, Alyson A Kelvin
Post-acute sequelae of COVID-19 (PASC) or the continuation of COVID-19 (Coronavirus disease 2019) symptoms past 12 weeks may affect as many as 30% of people recovering from a SARS-CoV-2 (severe acute respiratory coronavirus 2) infection. The mechanisms regulating the development of PASC are currently not known; however, hypotheses include virus reservoirs, pre-existing conditions, microblood clots, immune dysregulation, as well as poor antibody responses. Importantly, virus neutralizing antibodies are essential for COVID-19 recovery and protection from reinfection but there is currently limited information on these immune regulators and associated cytokines in PASC patients...
April 29, 2024: Scientific Reports