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JOURNAL ARTICLE
Mahya Samari, Soheila Kashanian, Sirus Zinadini, Hossein Derakhshankhah
A new drug delivery system using an asymmetric polyethersulfone (PES) membrane modified by SBA-15 and glutamine-modified SBA-15 (SBA-Q) was prepared in this study by the aim of azithromycin delivery enhancement in both in vitro and ex vivo experiments. The research focused on optimizing membrane performance by adjusting critical parameters including drug concentration, membrane thickness, modifier percentage, polymer percentage, and pore maker percentage. To characterize the fabricated membranes, various techniques were employed, including scanning electron microscopy, water contact angle, and tensile strength assessments...
May 6, 2024: Scientific Reports
#22
REVIEW
Ghumika Pandita, Carolina Krebs de Souza, Marcel Jefferson Gonçalves, Joanna Maria Jasińska, Ewelina Jamróz, Swarup Roy
Nowadays food safety and protection are a growing concern for food producers and food industry. The stability of food-grade materials is key in food processing and shelf life. Pickering emulsions (PEs) have gained significant attention in food regimes owing to their stability enhancement of food specimens. PE can be developed by high and low-energy methods. The use of PE in the food sector is completely safe as it uses solid biodegradable particles to stabilize the oil in water and it also acts as an excellent carrier of essential oils (EOs)...
May 4, 2024: International Journal of Biological Macromolecules
#23
JOURNAL ARTICLE
K Reilly, S Sonner, N McCay, D L Rolnik, F Casey, A N Seale, C J Watson, A Kan, T H T Lai, B H Y Chung, K E M Diderich, M I Srebniak, E Dempsey, S Drury, J Giordano, R Wapner, M D Kilby, L S Chitty, F Mone
OBJECTIVES: To determine the incremental yield of prenatal exome sequencing (PES) over standard testing in fetuses with an isolated congenital heart abnormality (CHA), CHA associated with extra-cardiac malformations (ECMs) and CHA dependent upon anatomical subclassification. METHODS: A systematic review of the literature was performed using MEDLINE, EMBASE, Web of Science and grey literature January 2010-February 2023. Studies were selected if they included greater than 20 cases of prenatally diagnosed CHA when standard testing (QF-PCR/chromosome microarray/karyotype) was negative...
May 6, 2024: Prenatal Diagnosis
#24
REVIEW
Katsutoshi Hiramatsu, Hideki Maeda
No systematic review of trial designs in patients with relapsing multiple sclerosis (RMS) was reported. This systematic review was conducted on the trial designs and primary end points (PEs) of phase II and III trials intended to modify the natural course of the disease in patients with RMS. The purpose of the study is to explore trends/topics and discussion points in clinical trial design and PE, comparing them to regulatory guidelines and expert recommendations. Three trial registration systems, ClinicalTrials...
May 2024: Clinical and Translational Science
#25
JOURNAL ARTICLE
Eva M Pena-Burgos, María C Díez-Corral, Eduardo J Ortiz-Cruz, Daniel Bernabéu, Mar Tapia-Viñe, Andrés Redondo, Antonio Pérez-Martínez, Alberto Peláez, Clara Venegas Mascaró, Adela Escudero López, Jose J Pozo-Kreilinger
Periosteal Ewing sarcoma (ES) is an exceedingly rare topographic subtype of the ES. To our knowledge, only 60 patients have been reported in the medical English language literature. It predominantly affects men in the second decade of life and arises in the long tubular bone diaphysis. PES rarely develops distant metastases. We report two patients of this rare ES location that were found on the distal tibial shaft and proximal femoral diaphysis of a 21-year-old man and an 8-year-old boy, respectively. Both patients were treated with neoadjuvant chemotherapy, wide resection, and adjuvant chemotherapy...
May 5, 2024: International Journal of Surgical Pathology
#26
JOURNAL ARTICLE
Stephen Stewart, Tun Kuan Yeo, Salissou Moutari, Richard McNeely, Jonathan E Moore
PURPOSE: To assess whether the use of measured posterior corneal astigmatism (PCA) values improves the prediction accuracy of toric intraocular lens power formulas, compared to predicted PCA values, when the orientation of the steep axis of PCA is non-vertical. DESIGN: Retrospective observational cohort study METHODS: 418 eyes of 344 patients were included in the study. Prediction errors (PE) for postoperative refractive astigmatism at 4 weeks postoperatively were determined using vector analysis and compared for the following toric intraocular lens power formulas: Barrett Toric with predicted posterior corneal astigmatism (PPCA); Barrett Toric with measured posterior corneal astigmatism (MPCA); EVO Toric PPCA; EVO Toric MPCA; Holladay I with Abulafia-Koch regression...
May 3, 2024: American Journal of Ophthalmology
#27
JOURNAL ARTICLE
Joe Opdenaker, Jarrod Blinch, Miranda Scolari
Post-error slowing (PES), the tendency to slow down a behavioral response after a previous error, has typically been investigated during simple cognitive tasks using response time as a measure of PES magnitude. More recently, PES was investigated during a single reach-to-grasp task to determine where post-error adjustments are employed in a more ecological setting. Kinematic analyses in the previous study detected PES during pre-movement planning and within the grasping component of movement execution. In the current study (N = 22), we increased the cognitive demands of a reach-to-grasp task by adding a choice between target and distractor locations to further explore PES, and other post-error adjustments, under different task conditions...
May 5, 2024: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
#28
JOURNAL ARTICLE
Er Mo, Zexin Chen, Ke Feng, Zehui Zhu, Jialin Xu, Chenyuan Zhu, Pingjun Chang, Jin Li, Yun-E Zhao
PURPOSE: To evaluate the predictive accuracy of modern intraocular lens (IOL) formulas and axial length (AL) adjusted traditional IOL formulas, including Wang-Koch and Cooke-modified AL (CMAL) method, in long eyes with plate-haptic IOLs, and to compare refractive prediction error variances with C-loop IOLs. DESIGN: Retrospective consecutive case series study. METHODS: Data from 391 eyes with Zeiss 509M and 302 eyes with Alcon SN6CWS implants in highly myopic patients, following cataract surgery from January 2019 to November 2023, were collected...
May 2, 2024: American Journal of Ophthalmology
#29
JOURNAL ARTICLE
Hassan Raza, Tiffany Tang, Baizhen Gao, Chelsea Phuangthong, Chienhung Billy Chen, Nuno D S Pinto
The growing demand for biological therapeutics has increased interest in large-volume perfusion bioreactors, but the operation and scalability of perfusion membranes remain a challenge. This study evaluates perfusion cell culture performance and monoclonal antibody (mAb) productivity at various membrane fluxes (1.5-5 LMH), utilizing polyvinylidene difluoride (PVDF), polyethersulfone (PES), or polysulfone (PS) membranes in tangential flow filtration mode. At low flux, culture with PVDF membrane maintained higher cell culture growth, permeate titer (1...
May 4, 2024: Biotechnology and Bioengineering
#30
JOURNAL ARTICLE
Riccardo Antonio Ricciuti, Fabrizio Mancini, Giusy Guzzi, Daniele Marruzzo, Alessandro Dario, Alessandro Della Puppa, Alessandro Ricci, Andrea Barbanera, Andrea Talacchi, Andreas Schwarz, Antonino Germanò, Antonino Raco, Antonio Colamaria, Antonio Santoro, Riccardo Boccaletti, Carlo Conti, Carlo Conti, Nunzia Cenci, Christian Cossandi, Claudio Bernucci, Corrado Lucantoni, Giovanni Battista Costella, Diego Garbossa, Donato Carlo Zotta, Federico De Gonda, Felice Esposito, Flavio Giordano, Giancarlo D'Andrea, Gianluca Piatelli, Gianluigi Zona, Giannantonio Spena, Giovanni Tringali, Giuseppe Barbagallo, Carlo Giussani, Maurizio Gladi, Andrea Landi, Angelo Lavano, Letterio Morabito, Luciano Mastronardi, Marco Locatelli, Michele D'Agruma, Michele Maria Lanotte, Nicola Montano, Orazio Santo Santonocito, Angelo Pompucci, Raffaele de Falco, Franco Randi, Sara Bruscella, Ivana Sartori, Francesco Signorelli, Luigino Tosatto, Roberto Trignani, Vincenzo Esposito, Gualtiero Innocenzi, Sergio Paolini, Vincenzo Vitiello, Michele Alessandro Cavallo, Francesco Sala
INTRODUCTION: Intraoperative Neurophysiological Monitoring (IOM) is widely used in neurosurgery but specific guidelines are lacking. Therefore, we can assume differences in IOM application between Neurosurgical centers. RESEARCH QUESTION: The section of Functional Neurosurgery of the Italian Society of Neurosurgery realized a survey aiming to obtain general data on the current practice of IOM in Italy. MATERIALS AND METHODS: A 22-item questionnaire was designed focusing on: volume procedures, indications, awake surgery, experience, organization and equipe...
2024: Brain Spine
#31
JOURNAL ARTICLE
Ali Barikroo
INTRODUCTION: Effortful Swallow (ES) is a widely used technique in dysphagia management, believed to strengthen oropharyngeal muscles and enhance swallowing safety and efficiency. Although its impact on the oral phase of swallowing is well-documented, its effects on pharyngeal swallowing physiology remain inconsistent. This study aimed to elucidate the effects of ES on swallowing kinematics and timing, addressing existing inconsistencies in the literature. METHODS: This study involved 22 healthy adults using archived videofluoroscopic swallowing studies...
May 2, 2024: Folia Phoniatrica et Logopaedica
#32
JOURNAL ARTICLE
Feng Zhan, Guo-Liang Lin, Teng-Shuo Zhang, Kewei Xu, Yun-Fang Yang, Guijie Li, Yuanbin She
This study presents the rare examples of S-heteroaryl tetradentate Pt(S^C^N^O) luminescent complexes ( PtSZ and PtSZtBu ) containing a Pt-S bond. The presence of the Pt-S bond allows the novel Pt(S^C^N^O) complexes to exhibit temperature-dependent phosphorescent emission behavior. The PtSZtBu exhibits dual-emission phenomena and biexponential transient decay spectra above 250 K, indicating the presence of two minimal excited states in the potential energy surface (PES) of the T1 state. Through complementary experimental and computational studies, we have identified changes in orbital composition between Pt(dxy )-S(px ) and Pt(dyz )-S(pz ) in excited states with increasing temperature...
May 2, 2024: Inorganic Chemistry
#33
JOURNAL ARTICLE
Marius C Vollberg, Mina Cikara
People generally empathize with others and find harm aversive. Yet aggression, for example, between groups, abounds. How do people learn to overcome this aversion in order to aggress? Many models of learning emphasize outcome prediction errors-deviations from expected outcomes in the environment-but aggression may also be fueled by affective prediction errors (affective PEs)-deviations from how we expect to feel. Across five preregistered online experiments that hold outcome prediction errors constant ( N = 4,607), participants choosing aggressive or nonaggressive actions aggressed more against disliked group members and often escalated or persisted in taking actions that felt better than expected (positive affective PE), especially when those actions were aggressive...
May 2, 2024: Journal of Experimental Psychology. General
#34
JOURNAL ARTICLE
Monika Kumari, Natish Kumar, Sunny Kumar, Shivani Gandhi, Eyal Zussman, Ravi Kumar Arun
We present a colorimetric probe based on polyvinylpyrrolidone-capped gold nanoparticles (PVP-AuNPs) that is sensitive and selective for cysteine (Cys). A microfluidic paper-based analytical device (μ-PAD) with embedded dried PVP-AuNPs at the polyethersulfone (PES) paper surface is used for Cys detection. When thiol molecules attach to PVP-AuNPs in the presence of Cys, they clump together, and this causes the solution's color to shift from red to blue within 5 minutes. The device is capable of detecting Cys levels between 1...
May 2, 2024: Analytical Methods: Advancing Methods and Applications
#35
Suaad Hamsho, Ahmad Almohamed, Hasan Haydar, Yousef Alsaffaf, Enas Sultan, Yassen Sukkar, Waddah Kazkz
INTRODUCTION: Charcot-Marie-Tooth (CMT) is a group of inherited neuromuscular disorders that vary clinically and genetically. It is characterized by peripheral nerve damage, leading to muscle weakness and sensory loss. CASE PRESENTATION: A 13-year-old male presented to the rheumatology department with bilateral hearing impairment since the age of 3 years, pes cavus, and difficulties walking. Some family members had Achilles tendon lengthening surgery. During physical examination, the patient had a shortened Achilles tendon, there are high arches in the feet, curled toes, loss of touch sensation in the feet, ankles, and legs, atrophy in the foot muscles...
May 2024: Annals of Medicine and Surgery
#36
JOURNAL ARTICLE
Ahsan Habib, Md Abdullah Al Mamun, Osman Babaarslan
Textile industries are now focusing on sustainable issues in manufacturing operations to save the environment. The study focuses on the use of cotton fibers (recycled) sourced from fabric (knitted) waste (pre-consumer) to manufacture elastic yarn (dual-core) for denim fabric. The study involves the production of yarns (dual-core) using a redesigned ring spinning method with different elastomeric components, including T400® (Polyethylene terephthalate)/Polytrimethylene terephthalate), Polybutylene terephthalate (PBT), Polyester (PES), Lycra® (elastane), virgin cotton and cotton (recycled) fiber...
May 15, 2024: Heliyon
#37
RANDOMIZED CONTROLLED TRIAL
Barnpot Nakornnoi, Jamsak Tscheikuna, Nuttapol Rittayamai
BACKGROUND: Patient-ventilator asynchrony commonly occurs during pressure support ventilation (PSV). IntelliSync + software (Hamilton Medical AG, Bonaduz, Switzerland) is a new ventilation technology that continuously analyzes ventilator waveforms to detect the beginning and end of patient inspiration in real time. This study aimed to evaluate the physiological effect of IntelliSync + software on inspiratory trigger delay time, delta airway (Paw ) and esophageal (Pes ) pressure drop during the trigger phase, airway occlusion pressure at 0...
May 1, 2024: BMC Pulmonary Medicine
#38
REVIEW
Gianmaria Cammarota, Rosanna Vaschetto, Luigi Vetrugno, Salvatore M Maggiore
PURPOSE OF REVIEW: This review explores lung recruitment monitoring, covering techniques, challenges, and future perspectives. RECENT FINDINGS: Various methodologies, including respiratory system mechanics evaluation, arterial bold gases (ABGs) analysis, lung imaging, and esophageal pressure (Pes) measurement are employed to assess lung recruitment. In support to ABGs analysis, the assessment of respiratory mechanics with hysteresis and recruitment-to-inflation ratio has the potential to evaluate lung recruitment and enhance mechanical ventilation setting...
June 1, 2024: Current Opinion in Critical Care
#39
JOURNAL ARTICLE
Gianmaria Cammarota, Rosanna Vaschetto, Luigi Vetrugno, Salvatore M Maggiore
PURPOSE OF REVIEW: This review explores lung recruitment monitoring, covering techniques, challenges, and future perspectives. RECENT FINDINGS: Various methodologies, including respiratory system mechanics evaluation, arterial bold gases (ABGs) analysis, lung imaging, and esophageal pressure (Pes) measurement are employed to assess lung recruitment. In support to ABGs analysis, the assessment of respiratory mechanics with hysteresis and recruitment-to-inflation ratio has the potential to evaluate lung recruitment and enhance mechanical ventilation setting...
March 28, 2024: Current Opinion in Critical Care
#40
JOURNAL ARTICLE
Paul Guibourg, Léo Dontot, Pierre-Matthieu Anglade, Benoit Gervais
We present a modification to self-consistent charge density functional-based tight binding (SCC-DFTB), which allows computation based on approximate atomic charges. We obtain these charges by means of a machine learning (ML) process that combines a Coulomb model with a neural network. This allows us to avoid the SCC cycles in the SCC-DFTB calculation while maintaining its accuracy. The main input of the model is the atomic positions characterized by a set of atom-centered symmetry functions. The charge inference from our ML algorithm is as close as 10-2 units of charge from the exact SCC solution...
May 1, 2024: Journal of Chemical Theory and Computation
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