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JOURNAL ARTICLE
Robert S Rosenson, Daniel Gaudet, Robert A Hegele, Christie M Ballantyne, Stephen J Nicholls, Kathryn J Lucas, Javier San Martin, Rong Zhou, Ma'an Muhsin, Ting Chang, Jennifer Hellawell, Gerald F Watts
BACKGROUND: Angiopoietin-like 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases and hepatic uptake of triglyceride-rich lipoprotein remnants. ANGPTL3 loss-of-function carriers have lower levels of triglycerides, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol and a lower risk of atherosclerotic cardiovascular disease than noncarriers. Zodasiran is an RNA interference (RNAi) therapy targeting expression of ANGPTL3 in the liver...
May 29, 2024: New England Journal of Medicine
#2
JOURNAL ARTICLE
Jun He, Xipan Hu, Xingyong Weng, Haikun Wang, Jianwei Yu, Tingqing Jiang, Lintao Zou, Xuan Zhou, ZhiXian Lyu, Jian Liu, PengJi Zhou, Xilin Xiao, Deshuai Zhen, Zhongliang Deng
To address the limitations of the CRISPR/Cas12f1 system in clinical diagnostics, which require the complex preparation of single-stranded DNA (ssDNA) or in vitro transcripts (RNA), we developed a fluorescent biosensor named PDTCTR (PAM-dependent dsDNA Target-activated Cas12f1 Trans Reporter). This innovative biosensor integrates Recombinase Polymerase Amplification (RPA) with the Cas12f_ge4.1 system, facilitating the direct detection of double-stranded DNA (dsDNA). PDTCTR represents a significant leap forward, exhibiting a detection sensitivity that is a hundredfold greater than the original Cas12f1 system...
May 24, 2024: Biosensors & Bioelectronics
#3
JOURNAL ARTICLE
Adrienne Barrett, Kali Holder, Susan Knowles, Elise E B LaDouceur
American pikas ( Ochotona princeps ) are small lagomorphs that live in mountainous talus areas of western North America. Studies on the histopathology of American pikas are limited. We summarize here the clinical histories, and gross and histologic findings of 12 American pikas, including 9 captive (wild-caught) and 3 wild animals. Death was often attributed to stress (transport, handling, anesthesia) with few-to-no premonitory clinical signs. Infection was the cause of death in 2 cases: 1 had bacterial pyogranulomatous dermatitis, cellulitis, and lymphadenitis with sepsis; the other case had oomycete-induced necrotizing colitis...
May 28, 2024: Journal of Veterinary Diagnostic Investigation
#4
JOURNAL ARTICLE
Mu-Gen Dai, Si-Yu Liu, Lin Zhu, Wen-Feng Lu, Gui-Lin Xie, Lei Liang, Jun-Wei Liu, Bin Ye
BACKGROUND & AIMS: To examine the association of the history of preoperative antiviral therapy (AVT) with the tumor recurrence and overall survival in HBV-related HCC patients undergoing curative-intent hepatectomy. METHODS: Patients who underwent curative-intent hepatectomy for HBV-related HCC between 2014 and 2019 at 4 Chinese hospitals were analyzed. Patients were categorized as having undergone preoperative antiviral therapy (AVT) > 1 year or without antiviral therapy (non-AVT)...
2024: Journal of Hepatocellular Carcinoma
#5
JOURNAL ARTICLE
Elizabeth Abban, Emmanuel Owusu, Benedicta Kwakye-Abebrese, Bright Koduah, Hannah Boateng, Emmanuel Ekow Korsah, Alfred Effah, Solomon Akpobi, Emmanuel Avoh-Ackah, Ebenezer Senu
BACKGROUND: Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV) and major global health problem, affecting millions of people globally. Whilst college or university students could serve as a positive vehicle that may aid in the propagation of education in the communities, there is currently paucity of data on knowledge of HBV and vaccination awareness among university students in Ghana. This study therefore assessed knowledge on hepatitis B virus infection, testing, and vaccination awareness among science and non-science students in Ghana...
2024: Scientifica
#6
JOURNAL ARTICLE
Loreta A Kondili, Giuseppina Brancaccio, Maria Elena Tosti, Barbara Coco, Maria Giovanna Quaranta, Vincenzo Messina, Alessia Ciancio, Filomena Morisco, Valentina Cossiga, Ernesto Claar, Valerio Rosato, Marianna Ciarallo, Irene Cacciola, Francesca Romana Ponziani, Lucia Cerrito, Roberta Coppola, Francesco Longobardi, Elisa Biliotti, Alessia Rianda, Francesco Barbaro, Nicola Coppola, Maria Stanzione, Francesco Barchiesi, Stefano Fagiuoli, Mauro Viganò, Marco Massari, Francesco Paolo Russo, Alberto Ferrarese, Diletta Laccabue, Vito Di Marco, Pierluigi Blanc, Aldo Marrone, Giulia Morsica, Alessandro Federico, Donatella Ieluzzi, Alba Rocco, Francesco Giuseppe Foschi, Alessandro Soria, Ivana Maida, Luchino Chessa, Michele Milella, Elena Rosselli Del Turco, Salvatore Madonia, Liliana Chemello, Ivan Gentile, Pierluigi Toniutto, Matteo Bassetti, Lorenzo Surace, Leonardo Baiocchi, Adriano Pellicelli, Adriano De Santis, Massimo Puoti, Elisabetta Degasperi, Grazia Anna Niro, Anna Linda Zignego, Antonio Craxi, Giovanni Raimondo, Teresa Antonia Santantonio, Maurizia Rossana Brunetto, Giovanni Battista Gaeta, On Behalf Of Piter Collaborating Investigators
BACKGROUND AND AIMS: We aimed to characterize the epidemiologic and comorbidities profiles of patients with chronic Hepatitis D (CHD) followed in clinical practice in Italy and explored their interferon (IFN) eligibility. METHODS: This was a cross-sectional study of the PITER cohort consisting of consecutive HBsAg-positive patients from 59 centers over the period 2019-2023. Multivariable analysis was performed by logistic regression model. RESULTS: Of 5,492 HBsAg-positive enrolled patients, 4,152 (75...
May 25, 2024: International Journal of Infectious Diseases: IJID
#7
JOURNAL ARTICLE
Nagisa Hara, Atsushi Hiraoka, Masato Nakai, Makoto Shiraki, Tadashi Namisaki, Hisamitsu Miyaaki, Takuro Hisanaga, Hirokazu Takahashi, Hideko Ohama, Fujimasa Tada, Naoya Sakamoto, Kazuhiko Nakao, Taro Takami, Yuichiro Eguchi, Hitoshi Yoshiji
AIM: It is not uncommon to encounter outpatients in the hepatology department with harmful alcohol habits. When treating such chronic liver disease (CLD) patients, an adequate intervention method for harm reduction of alcohol use, such as brief intervention (BI) or BI and nalmefene, should be considered. This study aimed to elucidate the clinical effectiveness of BI for CLD patients affected by harmful alcohol use. METHODS: From June 2021 to 2023, 123 Japanese CLD outpatients (hepatitis B virus : hepatitis C virus : alcoholic liver disease : others = 32:18:42:31) with an Alcohol Use Disorders Identification Test (AUDIT) score of ≥8 at the initial interview and a repeat interview with AUDIT 9 months later were enrolled...
May 27, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#8
REVIEW
Seung Kak Shin, Sooyeon Oh, Su-Kyung Chun, Min-Ji Ahn, Seung-Min Lee, Kayun Kim, Hogyeong Kang, Jeongwoo Lee, Suk Pyo Shin, Jooho Lee, Young Kul Jung
Natural killer (NK) cells are one of the key members of innate immunity that predominantly reside in the liver, potentiating immune responses against viral infections or malignant tumors. It has been reported that changes in cell numbers and function of NK cells are associated with the development and progression of chronic liver diseases (CLDs) including non-alcoholic fatty liver disease, alcoholic liver disease, and chronic viral hepatitis. Also, it is known that the crosstalk between NK cells and hepatic stellate cells plays an important role in liver fibrosis and cirrhosis...
May 27, 2024: Journal of Gastroenterology and Hepatology
#9
JOURNAL ARTICLE
Nancy Yi Yang, Anthony Y Y Hsieh, Zhuo Chen, Amber R Campbell, Izabella Gadawska, Fatima Kakkar, Laura Sauve, Ari Bitnun, Jason Brophy, Melanie C M Murray, Neora Pick, Mel Krajden, Hélène C F Côté, Cihr Team On Cellular Aging And Hiv Comorbidities In Women And Children Carma
BACKGROUND: Chronic/latent viral infections may accelerate immunological aging, particularly among people living with HIV (PLWH). We characterized chronic/latent virus infections across their lifespan and investigated their associations with leukocyte telomere length (LTL). METHODS: Participants enrolled in the CARMA cohort study were randomly selected to include n = 15 for each decade of age between 0 and >60 y, for each sex, and each HIV status. Cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesvirus 8 (HHV-8), herpes simplex virus 1 (HSV-1), and HSV-2 infection were determined serologically; HIV, hepatitis C (HCV), and hepatitis B (HBV) were self-reported...
May 10, 2024: Viruses
#10
JOURNAL ARTICLE
N Begum Ozturk, Hoang Nhat Pham, Rama Mouhaffel, Ramzi Ibrahim, Marwan Alsaqa, Ahmet Gurakar, Behnam Saberi
(1) Background: Hepatocellular carcinoma (HCC) contributes to the significant burden of cancer mortality in the United States (US). Despite highly efficacious antivirals, chronic viral hepatitis (CVH) remains an important cause of HCC. With advancements in therapeutic modalities, along with the aging of the population, we aimed to assess the contribution of CVH in HCC-related mortality in the US between 1999-2020. (2) Methods: We queried all deaths related to CVH and HCC in the multiple-causes-of-death files from the CDC Wide-ranging Online Data for Epidemiologic Research (WONDER) database between 1999-2020...
April 28, 2024: Viruses
#11
REVIEW
Ciro Celsa, Marzia Veneziano, Francesca Maria Di Giorgio, Simona Cannova, Antonino Lombardo, Emanuele Errigo, Giuseppe Landro, Fabio Simone, Emanuele Sinagra, Vincenza Calvaruso
Clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic liver disease indicates an increased risk of decompensation and death. While invasive methods like hepatic venous-portal gradient measurement is considered the gold standard, non-invasive tests (NITs) have emerged as valuable tools for diagnosing and monitoring CSPH. This review comprehensively explores non-invasive diagnostic modalities for portal hypertension, focusing on NITs in the setting of hepatitis B and hepatitis C virus-related cirrhosis...
April 24, 2024: Medicina
#12
JOURNAL ARTICLE
Louise O Downs, Oscar Chirro, Mwanakombo Zaharani, Benson Safari, Dorcas Okanda, George Githinji, Monique I Andersson, Rob Newton, Anthony Etyang, Nadia Aliyan, Philippa Clare Matthews
OBJECTIVES: Chronic hepatitis B infection affects 65 million people in the WHO African Region, but only 4.2% of these are diagnosed and 0.2% on treatment. Here, we present a short report describing establishment of a hepatitis B virus (HBV) programme in Kenya. We share experiences, successes and challenges to support development of future programmes. METHODS: From March 2023, we began the 'STRIKE-HBV' Study to identify people living with HBV (PLWHB) in Kilifi, Kenya...
May 24, 2024: Sexually Transmitted Infections
#13
JOURNAL ARTICLE
Margarita Papatheodoridi, Victor De Ledinghen, Monica Lupsor-Platon, Fabrizio Bronte, Jerome Boursier, Omar Elshaarawy, Fabio Marra, Maja Thiele, Georgios Markakis, Audrey Payance, Edgar Brodkin, Laurent Castera, George Papatheodoridis, Aleksander Krag, Umberto Arena, Sebastian Mueller, Paul Cales, Vincenza Calvaruso, Adele Delamarre, Massimo Pinzani, Emmanuel A Tsochatzis
BACKGROUND: Agile scores, including liver stiffness measurements (LSM) and routine clinical/laboratory biomarkers, have been developed for advanced fibrosis (F≥3) and cirrhosis, respectively, in patients with metabolic-associated steatotic liver disease (MASLD). We independently validated the diagnostic accuracy of these scores in MASLD, alcohol-related liver disease (ALD) and chronic hepatitis B or C (CHB/C) and assessed them in clinical algorithms with FIB-4 and LSM. METHODS: We included 4,243 patients (MASLD:912, ALD:386, CHB:597, CHC:2348) with LSM, liver biopsy and laboratory tests within 6 months...
May 22, 2024: Journal of Hepatology
#14
JOURNAL ARTICLE
Zhenyu Zhou, Wei Yu, Huoming Li, Juanyi Shi, Shiyu Meng, Yongcong Yan, Ruibin Chen, Haohan Liu, Jie Wang, Jian Sun, Zhiyu Xiao, Jianlong Zhang
HBV-associated hepatocellular carcinoma (HCC) represents the prevalent form of HCC, with HBx protein being a crucial oncoprotein. Numerous members of the protein tyrosine phosphatase non-receptor (PTPN) family have been confirmed to be significantly associated with the occurrence and progression of malignant tumors. Our group has previously identified the involvement of PTPN13 in HCC. However, the roles of other PTPNs in HCC still requires further investigation. In this study, we found PTPN18 expression was significantly downregulated within HCC tissues compared to that in adjacent non-tumor tissues and normal liver tissues...
May 24, 2024: Molecular Cancer Research: MCR
#15
REVIEW
Lohit Ramachandran, Farah Abul Rub, Amro Hajja, Ibrahim Alodhaibi, Momo Arai, Mohammed Alfuwais, Tariq Makhzoum, Ahmed Yaqinuddin, Khaled Al-Kattan, Abdullah M Assiri, Dieter C Broering, Raja Chinnappan, Tanveer Ahmad Mir, Naresh Kumar Mani
Hepatocellular carcinoma (HCC) is currently one of the most prevalent cancers worldwide. Associated risk factors include, but are not limited to, cirrhosis and underlying liver diseases, including chronic hepatitis B or C infections, excessive alcohol consumption, nonalcoholic fatty liver disease (NAFLD), and exposure to chemical carcinogens. It is crucial to detect this disease early on before it metastasizes to adjoining parts of the body, worsening the prognosis. Serum biomarkers have proven to be a more accurate diagnostic tool compared to imaging...
May 8, 2024: Biosensors
#16
JOURNAL ARTICLE
Naresh Kumar, Amanullah Abbasi, Sana Muhammad Hussain, Aysal Mahmood, Kanhiyalal Talreja
Along with infecting hepatocytes, the Hepatitis C virus (HCV) is also a lymphotropic virus. Chronic HCV infection can mutate the Bcl2, a proto-oncogene that inhibits apoptosis. This causes continuous stimulation of B lymphocytes, which results in clonal growth of these immunoglobulin-producing cells. In Western countries, there is a well-documented link between HCV and lymphoproliferative illness. HCV and Non-Hodgkin lymphoma (NHL) have been found to be significantly correlated in Europe, Japan, and the southern United States...
May 2024: JPMA. the Journal of the Pakistan Medical Association
#17
JOURNAL ARTICLE
Haiqing Sun, Ning Liu, Jinli Lou
OBJECTIVE: This study aimed to investigate the diagnostic value of stress-induced phosphoprotein 1 (STIP1) in serum for hepatocellular carcinoma (HCC) and alpha-fetoprotein (AFP)-negative HCC (ANHC). METHODS: In this study, serum samples were collected from 158 HCC patients and 63 non-HCC patients. Logistic regression analysis was performed to identify independent risk factors associated with HCC and ANHC. The diagnostic values of each index for HCC and ANHC were analyzed using receiver operating characteristic (ROC) curve analysis...
May 23, 2024: Laboratory Medicine
#18
JOURNAL ARTICLE
Irmak Ferah Okkay, Ademola Famurewa, Cemil Bayram, Ufuk Okkay, Ali Sefa Mendil, Selma Sezen, Teslime Ayaz, Ibrahim Gecili, Mustafa Ozkaraca, Selcuk Senyayla, Ahmet Hacimuftuoglu
BACKGROUND: Cisplatin is a potent anticancer agent widely employed in chemotherapy. However, cisplatin leads to toxicity on non-targeted healthy organs, including the liver. We investigated the hepatoprotective mechanism of arbutin (ARB), a glycosylated hydroquinone, against cisplatin-induced hepatotoxicity. METHODS: Rats were orally administered with ARB (ARB1 = 50 mg/kg; ARB2 = 100 mg/kg) for 14 consecutive days against hepatotoxicity induced by a single dose of cisplatin (10 mg/kg) on day 15...
June 2024: Toxicology Research
#19
REVIEW
Tugba Erdogan, Cagri Cansu, Belgin Kocer, Sedanur Akkaya, Helin Kokmen
OBJECTIVE: The aim of this study was to evaluate postmarketing ocrelizumab safety and effectiveness in a real-world population with multiple sclerosis (MS) and matching these parameters among MS disease types. METHODS: This was a retrospective, single-center study with MS patients treated with ocrelizumab. Demographic, clinical characteristics and immunological data were analyzed, including annualized relapse rate (ARR), relapse-free rate, Expanded Disability Status Scale (EDSS), complete blood count parameters, immunoglobulin (Ig) levels, liver function tests (LFT), hepatitis markers and adverse events in the 4-year follow-up...
May 20, 2024: Acta Neurologica Belgica
#20
JOURNAL ARTICLE
H Vu, D Huy, B N Minh Nhut, P A Quan, N Q Quyen, T T Thu Thuy, T T Khanh Tuong, N Minh Duc
BACKGROUND: Various non-invasive methods have been studied for assessing the fibrosis stage in patients with chronic hepatitis B. However, the performance of APGA, Fibrosis index in diagnosing liver fibrosis remains unclear globally and specifically in Vietnam. METHODS: An analytical cross-sectional study was performed among 242 patients treated at Thong Nhat Hospital. RESULTS: Both the APGA index and Fibrosis index showed good accuracy in diagnosing significant fibrosis (≥ F2), advanced liver fibro-sis (≥ F3), and cirrhosis (F4) with an area under the curve (AUROC) greater than 0...
2024: La Clinica Terapeutica
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