keyword
https://read.qxmd.com/read/38675446/a-non-toxic-binuclear-vanadium-iv-complex-as-insulin-adjuvant-improves-the-glycemic-control-in-streptozotocin-induced-diabetic-rats
#21
JOURNAL ARTICLE
Mateus S Lopes, Gabriel B Baptistella, Giovana G Nunes, Matheus V Ferreira, Joice Maria Cunha, Kauê Marcel de Oliveira, Alexandra Acco, Maria Luiza C Lopes, Alexessander Couto Alves, Glaucio Valdameri, Vivian R Moure, Geraldo Picheth, Graciele C M Manica, Fabiane G M Rego
Diabetes mellitus (DM) complications are a burden to health care systems due to the associated consequences of poor glycemic control and the side effects of insulin therapy. Recently. adjuvant therapies, such as vanadium compounds, have gained attention due to their potential to improve glucose homeostasis in patients with diabetes. In order to determine the anti-diabetic and antioxidant effects of the oxidovanadium(IV) complex (Et3 NH)2 [{VO(OH}2 )(ox)2 (µ-ox)] or Vox2), rats with streptozotocin (STZ)-induced diabetes were treated with 30 and 100 mg/kg of Vox2, orally administered for 12 days...
April 11, 2024: Pharmaceuticals
https://read.qxmd.com/read/38674860/supplementation-of-silymarin-alone-or-in-combination-with-salvianolic-acids-b-and-puerarin-regulates-gut-microbiota-and-its-metabolism-to-improve-high-fat-diet-induced-nafld-in-mice
#22
JOURNAL ARTICLE
Xin Wang, Yufeng Jin, Can Di, Yupeng Zeng, Yuqing Zhou, Yu Chen, Zhijun Pan, Zhongxia Li, Wenhua Ling
Silymarin, salvianolic acids B, and puerarin were considered healthy food agents with tremendous potential to ameliorate non-alcoholic fatty liver disease (NAFLD). However, the mechanisms by which they interact with gut microbiota to exert benefits are largely unknown. After 8 weeks of NAFLD modeling, C57BL/6J mice were randomly divided into five groups and fed a normal diet, high-fat diet (HFD), or HFD supplemented with a medium or high dose of Silybum marianum extract contained silymarin or polyherbal extract contained silymarin, salvianolic acids B, and puerarin for 16 weeks, respectively...
April 14, 2024: Nutrients
https://read.qxmd.com/read/38672991/longterm-outcome-of-therapeutic-vaccination-with-a-third-generation-pre-s-s-hbv-vaccine-prehevbrio-r-of-chronically-hbv-infected-patients
#23
JOURNAL ARTICLE
Hedwig Roggendorf, Daniel Shouval, Michael Roggendorf, Guido Gerken
Several antiviral treatment regimens for chronic hepatitis B (CHB) virus infection have been shown to be effective in suppressing viral load and reducing the risk of hepatocellular injury and its complications. It has been hypothesized that high levels of circulating HBV surface antigen(s) may lead to immune tolerance against HBV and contribute to chronic carriership. Conversely, low-level HBsAg may create a window for the reconstitution of an HBV-specific immune response through vaccination and control of infection...
March 29, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38672595/time-restricted-feeding-attenuates-metabolic-dysfunction-associated-steatohepatitis-and-hepatocellular-carcinoma-in-obese-male-mice
#24
JOURNAL ARTICLE
Manasi Das, Deepak Kumar, Consuelo Sauceda, Alexis Oberg, Lesley G Ellies, Liping Zeng, Lily J Jih, Isabel G Newton, Nicholas J G Webster
Metabolic dysfunction-associated steatotic liver disease (MASLD) has surpassed the hepatitis B virus and hepatitis C virus as the leading cause of chronic liver disease in most parts of the Western world. MASLD (formerly known as NAFLD) encompasses both simple steatosis and more aggressive metabolic dysfunction-associated steatohepatitis (MASH), which is accompanied by inflammation, fibrosis, and cirrhosis, and ultimately can lead to hepatocellular carcinoma (HCC). There are currently very few approved therapies for MASH...
April 16, 2024: Cancers
https://read.qxmd.com/read/38669864/protein-disulfide-isomerase-a1-regulates-fenestration-dynamics-in-primary-mouse-liver-sinusoidal-endothelial-cells-lsecs
#25
JOURNAL ARTICLE
Izabela Czyzynska-Cichon, Magdalena Giergiel, Grzegorz Kwiatkowski, Anna Kurpinska, Kamila Wojnar-Lason, Patrycja Kaczara, Marek Szymonski, Malgorzata Lekka, Ivars Kalvins, Bartlomiej Zapotoczny, Stefan Chlopicki
Protein disulfide isomerases (PDIs) are involved in many intracellular and extracellular processes, including cell adhesion and cytoskeletal reorganisation, but their contribution to the regulation of fenestrations in liver sinusoidal endothelial cells (LSECs) remains unknown. Given that fenestrations are supported on a cytoskeleton scaffold, this study aimed to investigate whether endothelial PDIs regulate fenestration dynamics in primary mouse LSECs. PDIA3 and PDIA1 were found to be the most abundant among PDI isoforms in LSECs...
April 16, 2024: Redox Biology
https://read.qxmd.com/read/38666599/clinical-outcomes-of-hepatocellular-carcinoma-surveillance-in-melbourne-australia
#26
JOURNAL ARTICLE
Samuel Hui, Andrew Nguyen, Suong Le, Anouk Dev, Sally Bell
BACKGROUND: Ultrasound surveillance for hepatocellular carcinoma (HCC) may improve early tumour detection but may additionally result in surveillance-related harm through increased evaluation of non-HCC lesions. The incidence of these outcomes has not been reported outside North America. AIMS: We aimed to report the outcomes of HCC surveillance with respect to both surveillance-related benefits and harms. METHODS: We reviewed all HCC surveillance ultrasounds at a large Victorian tertiary hospital network in 2017 and followed their outcomes until 2021...
April 26, 2024: Internal Medicine Journal
https://read.qxmd.com/read/38660346/influence-of-language-barrier-and-cultural-background-in-hepatitis-b-disease-knowledge-in-a-chinese-community-of-spain
#27
JOURNAL ARTICLE
Anna Pocurull, Cristina Collazos, Anna Miralpeix, Laura Tapias, Tao Wang, María Jose Moreta, Zoe Mariño, Sabela Lens, Xavier Forns
INTRODUCTION: Hepatitis B infection (HBV) is prevalent in China. Due to language barriers and cultural differences, it is not always straightforward to evaluate disease knowledge in liver clinics. We aimed to assess the awareness on HBV and its mechanisms of transmission in HBV-infected Chinese patients and their household contacts. METHODS: HBV-infected Chinese patients and their contacts were interviewed by a native Chinese nurse regarding their knowledge on HBV transmission mechanisms, use of preventive measures and vaccination status...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38659788/venous-excess-ultrasonography-vexus-captures-dynamic-changes-in-volume-status-surrounding-hemodialysis-a-multicenter-prospective-observational-study
#28
Katarina Leyba, August Longino, Ryen Ormesher, Mary Krienke, Natalie Van Ochten, Katherine Zimmerman, Luke McCormack, Katharine Martin, Theresa Thai, Seth Furgeson, Isaac Teitelbaum, Joseph Burke, Ivor Douglas, Edward Gill
Background: The evaluation of volume status is essential to clinical decision-making, yet multiple studies have shown that physical exam does not reliably estimate a patient's intravascular volume. Venous excess ultrasound score (VExUS) is an emerging volume assessment tool that utilizes inferior vena cava (IVC) diameter and pulse-wave Doppler waveforms of the portal, hepatic and renal veins to evaluate venous congestion. A point-of-care ultrasound exam initially developed by Beaubein-Souligny et al., VExUS represents a reproducible, non-invasive and accurate means of assessing intravascular congestion...
April 8, 2024: Research Square
https://read.qxmd.com/read/38659485/inhibition-of-hepatitis-b-virus-via-selective-apoptosis-modulation-by-chinese-patent-medicine-liuweiwuling-tablet
#29
JOURNAL ARTICLE
Fei-Lin Ge, Yan Yang, Lan-Lan Si, Yuan-Hua Li, Meng-Zhen Cao, Jun Wang, Zhao-Fang Bai, Zhi-Gang Ren, Xiao-He Xiao, Yan Liu
BACKGROUND: Liuweiwuling Tablet (LWWL) is a Chinese patent medicine approved for the treatment of chronic inflammation caused by hepatitis B virus (HBV) infection. Previous studies have indicated an anti-HBV effect of LWWL, specifically in terms of antigen inhibition, but the underlying mechanism remains unclear. AIM: To investigate the potential mechanism of action of LWWL against HBV. METHODS: In vitro experiments utilized three HBV-replicating and three non-HBV-replicating cell lines...
April 7, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38659046/long-term-remission-and-survival-in-patients-with-relapsed-or-refractory-multiple-myeloma-after-treatment-with-lcar-b38m-car-t-cells-5-year-follow-up-of-the-legend-2-trial
#30
MULTICENTER STUDY
Jie Xu, Bai-Yan Wang, Shan-He Yu, Shi-Jun Chen, Shuang-Shuang Yang, Rui Liu, Li-Juan Chen, Jian Hou, Zhu Chen, Wan-Hong Zhao, Ai-Li He, Jian-Qing Mi, Sai-Juan Chen
BACKGROUND: The autologous anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell therapy LCAR-B38M has been approved for the treatment of relapsed and refractory multiple myeloma in many countries across the world under the name ciltacabtagene autoleucel. LEGEND-2 was the first-in-human trial of LCAR-B38M and yielded deep and durable therapeutic responses. Here, we reported the outcomes in LEGEND-2 after a minimal 5-year follow-up. METHODS: Participants received an average dose of 0...
April 24, 2024: Journal of Hematology & Oncology
https://read.qxmd.com/read/38658506/inpatient-cost-burdens-of-treating-chronic-hepatitis-b-in-us-hospitals-a-weighted-analysis-of-a-national-database
#31
JOURNAL ARTICLE
David Uihwan Lee, Kuntal Bhowmick, Sindhura Kolachana, Kimberly Schuster, Aneesh Bahadur, Ashton Harmacinski, Sophie Schellhammer, Gregory Hongyuan Fan, Ki Jung Lee, Catherine Sun, Hannah Chou, Zurabi Lominadze
BACKGROUND AND AIMS: This study evaluates the cost burdens of inpatient care for chronic hepatitis B (CHB). We aimed to stratify the patients based on the presence of cirrhosis and conduct subgroup analyses on patient demographics and medical characteristics. METHODS: The 2016-2019 National Inpatient Sample was used to select individuals diagnosed with CHB. The weighted charge estimates were derived and converted to admission costs, adjusting for inflation to the year 2016, and presented in United States Dollars...
April 24, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38656076/could-nanotechnology-improve-exercise-performance-evidence-from-animal-studies
#32
REVIEW
M R Lima, B J Moreira, R Bertuzzi, A E Lima-Silva
This review provides the current state of knowledge regarding the use of nutritional nanocompounds on exercise performance. The reviewed studies used the following nanocompounds: resveratrol-loaded lipid nanoparticles, folic acid into layered hydroxide nanoparticle, redox-active nanoparticles with nitroxide radicals, and iron into liposomes. Most of these nutritional nanocompounds seem to improve performance in endurance exercise compared to the active compound in the non-nanoencapsulated form and/or placebo...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38655904/epidemiology-and-assessment-of-hepatitis-b-positive-children-in-western-australia
#33
JOURNAL ARTICLE
Hannah Elizabeth Bartley, Emma Kate Lefroy Turner, Timothy John Ford, Sarah Cherian
AIM: To describe the characteristics of patients with chronic hepatitis B (CHB) presenting to a tertiary paediatric hospital in Perth, Western Australia. Review of implementation of previous follow-up recommendations for the cohort was also undertaken. METHOD: A retrospective data analysis of all individuals aged between 0 and 17 years presenting to the tertiary children's hospital who were hepatitis B surface antigen (HBsAg) positive over 8 years (2013-2020)...
April 24, 2024: Journal of Paediatrics and Child Health
https://read.qxmd.com/read/38654891/triglyceride-glucose-index-is-an-independent-risk-factor-for-hepatocellular-carcinoma-development-in-patients-with-hbv-related-liver-cirrhosis
#34
JOURNAL ARTICLE
Su-Hua Yang, Yi-Shan He, Shu-Qin Zheng, Xiu-Jun Zhang, Hong Dai, Yuan Xue
AIM: This study aimed to explore the effects of the triglyceride-glucose (TyG) index on hepatocellular carcinoma (HCC) development in patients with hepatitis B virus (HBV)-related liver cirrhosis (LC). METHODS: A total of 242 patients with HBV-related LC were enrolled and followed-up. Logistic regression analysis was performed to investigate risk factors for HCC. RESULTS: The median follow-up time was 37 months (range: 6-123 months). At the end of the follow-up, 11 (11...
2024: Journal of Hepatocellular Carcinoma
https://read.qxmd.com/read/38654438/phase-1-study-of-safety-and-tolerability-of-an-oral-contraceptive-containing-low-dose-ethinyl-oestradiol-combined-with-glecaprevir-pibrentasvir-treatment-in-healthy-premenopausal-women
#35
JOURNAL ARTICLE
Dee-Dee Shiller, Betty B Yao, Mong-Jen Chen, Amelia Orejudos, Nael M Mostafa, John F Marcinak, Margaret Burroughs, Craig Boyle
Glecaprevir/pibrentasvir (GLE/PIB) is an approved guideline-recommended chronic hepatitis C virus infection treatment. GLE/PIB coadministration with ethinyl oestradiol (EE) is not recommended in current labels owing to a Phase 1 study observing Grade ≥2 alanine aminotransferase (ALT) elevation in 2 out of 12 healthy women cotreated for 11 days with GLE/PIB and oral contraceptive (OC) containing 35 μg/250 μg EE/norgestimate. No Grade ≥2 elevation was observed with low-dose (20 μg) EE (n = 14)...
April 23, 2024: Journal of Viral Hepatitis
https://read.qxmd.com/read/38654358/shared-genetic-factors-and-causal-association-between-chronic-hepatitis-c-infection-and-diffuse-large-b-cell-lymphoma
#36
JOURNAL ARTICLE
Leihua Fu, Jieni Yu, Zhe Chen, Feidan Gao, Zhijian Zhang, Jiaping Fu, Weiying Feng, Pan Hong, Jing Jin
BACKGROUND: Epidemiological research and systematic meta-analyses indicate a higher risk of B-cell lymphomas in patients with chronic hepatitis C virus (HCV) compared to non-infected individuals. However, the genetic links between HCV and these lymphomas remain under-researched. METHODS: Mendelian randomization analysis was employed to explore the association between chronic hepatitis C (CHC) and B-cell lymphomas as well as chronic lymphocytic leukemia (CLL). Approximate Bayes Factor (ABF) localization analysis was conducted to find shared genetic variants that might connect CHC with B-cell lymphomas and chronic lymphocytic leukemia (CLL)...
April 23, 2024: Infectious Agents and Cancer
https://read.qxmd.com/read/38653501/physiologically-based-pharmacokinetic-modeling-to-predict-the-impact-of-liver-cirrhosis-on-glucuronidation-via-ugt1a4-ugt2b7-2b4-a-case-study-with-midazolam
#37
JOURNAL ARTICLE
Agustos C Ozbey, Janneke Keemink, Bjoern Wagner, Alessandra Pugliano, Stephan Krähenbühl, Pieter Annaert, Stephen Fowler, Neil Parrott, Kenichi Umehara
Hepatic impairment, due to liver cirrhosis, decreases the activity of cytochrome P450 enzymes (CYPs). The use of physiologically-based pharmacokinetic (PBPK) modeling to predict this effect for CYP substrates has been well-established, but the effect of cirrhosis on uridine-glucuronosyltransferase (UGT) activities is less studied and few PBPK models have been reported. UGT enzymes are involved in primary N -glucuronidation of midazolam and glucuronidation of 1'-OH-midazolam following CYP3A hydroxylation. In this study Simcyp® was used to establish PBPK models for midazolam, its primary metabolites midazolam-N-glucuronide (UGT1A4) and 1'-OH midazolam (CYP3A4/3A5) and the secondary metabolite 1'-OH-midazolam-O-glucuronide (UGT2B7/2B4), allowing to simulate the impact of liver cirrhosis on the primary and secondary glucuronidation of midazolam...
April 23, 2024: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://read.qxmd.com/read/38653393/sophorin-mitigate-flutamide-induced-hepatotoxicity-in-wistar-rats
#38
JOURNAL ARTICLE
Rishi Sharma, Md Meraj Ansari, Manzar Alam, Mohammad Fareed, Nemat Ali, Anas Ahmad, Sarwat Sultana, Rehan Khan
Flutamide is frequently used in the management of prostate cancer, hirsutism, and acne. It is a non-steroidal anti-androgenic drug and causes hepatotoxicity. The current study's objective is to evaluate sophorin's hepatoprotective effectiveness against flutamide-induced hepatotoxicity in Wistar rats. Sophorin is a citrus flavonoid glycoside, also known as rutin, which is a low molecular weight polyphenolic compound with natural antioxidant properties and reported to have promising hepatoprotective efficacy...
April 21, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38653246/loss-of-gpr75-protects-against-non-alcoholic-fatty-liver-disease-and-body-fat-accumulation
#39
JOURNAL ARTICLE
Alasdair Leeson-Payne, Jean Iyinikkel, Cameron Malcolm, Brian Y H Lam, Nadine Sommer, Georgina K C Dowsett, Pablo B Martinez de Morentin, Dawn Thompson, Alasdair Mackenzie, Raffaella Chianese, Katherine Kentistou, Eugene J Gardner, John R B Perry, Felix Grassmann, John R Speakman, Justin J Rochford, Giles S H Yeo, Fiona Murray, Lora K Heisler
Approximately 1 in 4 people worldwide have non-alcoholic fatty liver disease (NAFLD); however, there are currently no medications to treat this condition. This study investigated the role of adiposity-associated orphan G protein-coupled receptor 75 (GPR75) in liver lipid accumulation. We profiled Gpr75 expression and report that it is most abundant in the brain. Next, we generated the first single-cell-level analysis of Gpr75 and identified a subpopulation co-expressed with key appetite-regulating hypothalamic neurons...
April 18, 2024: Cell Metabolism
https://read.qxmd.com/read/38652392/statewide-survey-of-primary-care-and-subspecialty-providers-on-hepatocellular-carcinoma-risk-stratification-and-surveillance-practices
#40
JOURNAL ARTICLE
Andrew M Moon, Rachel M Swier, Lindsay M Lane, A Sidney Barritt, Hanna K Sanoff, Andrew F Olshan, Stephanie B Wheeler, George N Ioannou, Nicole J Kim, Scott Hagan, Philip Vutien, Thad Benefield, Louise M Henderson
BACKGROUND: Hepatocellular carcinoma (HCC) surveillance in patients with cirrhosis is associated with improved survival. Provision of HCC surveillance is low in the US, particularly in primary care settings. AIMS: To evaluate current hepatitis C virus (HCV) and HCC surveillance practices and physician attitudes regarding HCC risk-stratification among primary care and subspecialty providers. METHODS: Using the Tailored Design Method, we delivered a 34-item online survey to 7654 North Carolina-licensed internal/family medicine or gastroenterology/hepatology physicians and advanced practice providers in 2022...
April 23, 2024: Digestive Diseases and Sciences
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