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JOURNAL ARTICLE
Victoria J Brookes, Caitlin E Henning, Kate A Worthing, Chris Degeling
Rheumatic heart disease (RHD) and acute rheumatic fever (ARF) disproportionately affect individuals in low-resource settings. ARF is attributed to an immune response to Group A Streptococcus (GAS) following GAS pharyngitis and potentially GAS impetigo in which infection can be initiated by scabies infestation. The burden of ARF and RHD in Aboriginal and Torres Strait Islander people in Australia is among the highest globally. Following recent calls to include dog management programs in ARF and RHD prevention programs, we believe it is timely to assess the evidence for this, particularly since previous recommendations excluded resources to prevent zoonotic canine scabies...
May 2024: PLoS Neglected Tropical Diseases
#2
JOURNAL ARTICLE
Fei Cheng, Beate I Escher, Huizhen Li, Maria König, Yujun Tong, Jiehui Huang, Liwei He, Xinyan Wu, Xiaohan Lou, Dali Wang, Fan Wu, Yuanyuan Pei, Zhiqiang Yu, Bryan W Brooks, Eddy Y Zeng, Jing You
Identifying causative toxicants in mixtures is critical, but this task is challenging when mixtures contain multiple chemical classes. Effect-based methods are used to complement chemical analyses to identify toxicants, yet conventional bioassays typically rely on an apical and/or single endpoint, providing limited diagnostic potential to guide chemical prioritization. We proposed an event-driven taxonomy framework for mixture risk assessment that relied on high-throughput screening bioassays and toxicant identification integrated by deep learning...
May 2, 2024: Environmental Science & Technology
#3
REVIEW
Emma Guttman-Yassky, Lila Bahadori, Laura Brooks, Ken L Clark, Hanna Grindebacke, Calvin N Ho, Rohit Katial, Tuyet-Hang Pham, Claire Walton, Catherine J Datto
WHAT IS THIS SUMMARY ABOUT?: Atopic dermatitis (AD) is a chronic (long-lasting) skin disease that leads to dry, itchy, and swollen red spots, which can also be painful and flare up at any time. Some people with AD have a high number of eosinophils, a type of white blood cell, which are associated with worse disease. Medicated creams and lotions, prescribed by health care providers, are meant to reduce the symptoms of AD. For some people, these creams and lotions do not work. Benralizumab injection is a medication that reduces and removes eosinophils...
May 2, 2024: Immunotherapy
#4
JOURNAL ARTICLE
Elizabeth A Holdsworth, Anna Berim, David R Gang, Janet E Williams, Caroline B Smith, Beatrice Caffé, Olivia Brooks, Celestina Barbosa-Leiker, Mark A McGuire, Michelle K McGuire, Courtney L Meehan
Background and Objectives: As cannabis use increases among reproductive-aged women, there is a growing need to better understand the presence of cannabinoids in milk produced by women using cannabis. It is unclear how concentrations of cannabinoids such as delta-9-tetrahydrocannabinol (Δ9 -THC) persist in milk after cannabis use and what factors contribute to variation in milk Δ9 -THC concentrations. Our objectives were to measure cannabinoids in human milk following cannabis abstention, after single and repeated instances of cannabis use, and identify factors contributing to concentration variation...
May 2, 2024: Breastfeeding Medicine
#5
JOURNAL ARTICLE
Nathaniel Webb, Samantha Matys, James B Collins, Julian Garcia, Kaleab Worku, Mandee Lines, Hailey Hirata, Erin Dark, Callee Brooks, Kaitlyn Buhlinger, Atalay Mulu Fentie, Megan C Roberts, Benyam Muluneh
INTRODUCTION: The increasing incidence of cancer and capacity for cancer care in Ethiopia has led to an upsurge in chemotherapy use in the country; however, studies indicate that there is a gap in the safe handling of chemotherapy by healthcare workers. There exists a need to understand if such unsafe practices occur in Ethiopia and, if so, which areas along the chemotherapy life cycle need the most improvement. METHODS: This study utilized a multi-method design through an online survey administered to health care professionals and evaluative site visits of eight cancer units in Addis Ababa, Ethiopia to understand the current conditions of chemotherapy handling...
May 2, 2024: Journal of Oncology Pharmacy Practice
#6
JOURNAL ARTICLE
Brooke Gessner, Michelle Carter, Kiana Rahnama, Alberto Almeida, Colleen Borralho, Tamara Mihic, Joan C Y Ng, Joseph H Puyat, Angela Russolillo, Katelyn C Halpape
INTRODUCTION: Clozapine is the most effective antipsychotic in the management of treatment-resistant schizophrenia; however, its use is challenging due to the risk of severe adverse effects. Despite the risks associated with clozapine, there is no mandatory monitoring in Canada beyond hematologic testing for agranulocytosis surveillance. This study focuses on the development, implementation, and evaluation of a clozapine clinical toolkit (CTK) targeted at optimizing inpatient clozapine use...
April 2024: Mental Health Clinician
#7
JOURNAL ARTICLE
Brook V Nelson
No abstract text is available yet for this article.
2024: Missouri Medicine
#8
JOURNAL ARTICLE
Maud Ahmad, Brooke A Kennedy, Surim Son, Adam D McIntyre, Julieta Lazarte, Jian Wang, Robert A Hegele
BACKGROUND AND AIMS: Severe hypertriglyceridemia (HTG), defined as plasma triglyceride (TG) concentration > 10 mmol/L, is relatively uncommon, and its implications for atherosclerotic cardiovascular disease (ASCVD) risk remain somewhat unclear. We evaluated the association between severe HTG and carotid intima-media thickness (IMT), a marker for ASCVD. METHODS: We studied three clinical cohorts: 88 patients with severe HTG (mean TG level 20.6 mmol/L), 271 patients with familial hypercholesterolemia (FH) as a contrast group, and 70 normolipidemic controls...
June 2024: Atheroscler Plus
#9
JOURNAL ARTICLE
Hila Shamon, Roi Maor, Michael V Cove, Roland Kays, Jessie Adley, Peter D Alexander, David N Allen, Maximilian L Allen, Cara L Appel, Evan Barr, Erika L Barthelmess, Carolina Baruzzi, Kelli Bashaw, Guillaume Bastille-Rousseau, Madison E Baugh, Jerrold Belant, John F Benson, Bethany A Bespoyasny, Tori Bird, Daniel A Bogan, LaRoy S E Brandt, Claire E Bresnan, Jarred M Brooke, Frances E Buderman, Suzannah G Buzzell, Amanda E Cheeseman, M Colter Chitwood, Petros Chrysafis, Merri K Collins, D Parks Collins, Justin A Compton, L Mike Conner, Olivia G Cosby, Stephanie S Coster, Benjamin Crawford, Anthony P Crupi, Andrea K Darracq, Miranda L Davis, Brett A DeGregorio, Kimberly L Denningmann, Kyle D Dougherty, Ace Driver, Andrew J Edelman, E Hance Ellington, Susan N Ellis-Felege, Caroline N Ellison, Jean E Fantle-Lepczyk, Zach J Farris, Jorie Favreau, Pilar Fernandez, M Caitlin Fisher-Reid, Matthew C Fitzpatrick, Elizabeth A Flaherty, Tavis D Forrester, Sarah R Fritts, Travis Gallo, Brian D Gerber, Sean T Giery, Jessica L Glasscock, Alex D Gonatas, Anna C Grady, Austin M Green, Tremaine Gregory, Noel Griffin, Robert H Hagen, Christopher P Hansen, Lonnie P Hansen, Steven C Hasstedt, Haydée Hernández-Yáñez, Daniel J Herrera, Robert V Horan, Victoria L Jackson, Luanne Johnson, Mark J Jordan, Willaine Kahano, Joseph Kiser, Travis W Knowles, Molly M Koeck, Caroline Koroly, Kellie M Kuhn, Erin K Kuprewicz, Diana J R Lafferty, Scott D LaPoint, Marcus Lashley, Richard G Lathrop, Thomas E Lee, Christopher A Lepczyk, Damon B Lesmeister, Jason V Lombardi, Robert A Long, Robert C Lonsinger, Paula MacKay, Sean P Maher, David S Mason, Joshua J Millspaugh, Remington J Moll, Jessica B Moon, Alessio Mortelliti, Alexis M Mychajliw, Christopher M Nagy, Sean A Neiswenter, Dana L Nelson, Claire E Nemes, Clayton K Nielsen, Elizabeth Olson, M Teague O'Mara, Brian J O'Neill, Blake R Page, Elizabeth Parsons, Brent S Pease, Mary E Pendergast, Mike Proctor, Heather Quick, Christine C Rega-Brodsky, Michael S Rentz, Kylie Rezendes, Daric Rich, Derek R Risch, Andrea Romero, Brigit R Rooney, Christopher T Rota, Corey A Samples, Christopher M Schalk, Çağan H Sekercioğlu, Maksim Sergeyev, Austin B Smith, Daniel S Smith, Jinelle H Sperry, Jennifer L Stenglein, Michael K Stokes, Johnathon S Stutzman, Kimberly R Todd, John P Vanek, Wren Varga, Zachary M Wardle, Stephen L Webb, Nathaniel H Wehr, Laura S Whipple, Christopher A Whittier, Jane S Widness, Jacque Williamson, Andrew M Wilson, Alexander J Wolf, Marketa Zimova, Adam S Zorn, William J McShea
SNAPSHOT USA is a multicontributor, long-term camera trap survey designed to survey mammals across the United States. Participants are recruited through community networks and directly through a website application (https://www.snapshot-usa.org/). The growing Snapshot dataset is useful, for example, for tracking wildlife population responses to land use, land cover, and climate changes across spatial and temporal scales. Here we present the SNAPSHOT USA 2021 dataset, the third national camera trap survey across the US...
May 1, 2024: Ecology
#10
REVIEW
John K Brooks, Azin Parsa, Jessica S Craig, Shereese Bell, Julia Song, Sharon L Varlotta, Jeffery B Price
BACKGROUND: Diffuse idiopathic skeletal hyperostosis (DISH) is a potentially serious osteopathic disorder associated with coalescing ossifications of the anterior vertebrae and may be concomitant with a constellation of symptomatology and systemic comorbidities. There is limited dental literature describing this finding on panoramic radiographs and cone beam computed tomography (CBCT) scans. CASE PRESENTATIONS: Two case reports of DISH are provided. One patient manifested extensive ossifications along the cervical vertebrae and consequent episodes of dysphagia and hoarseness...
May 1, 2024: Special Care in Dentistry
#11
JOURNAL ARTICLE
Hannah Kang Moran, Lori Spoozak, Joanna Veazey Brooks
This study aimed to elucidate the relationship between mentorship, survivorship, and identity construction in people who have had gynecologic cancer and participated as mentors in a peer mentorship program. A qualitative descriptive study was designed, and hour-long semi-structured interviews with peer mentors were conducted. Interviews investigated how serving as a peer mentor influenced understanding of mentors' own cancer experiences. Thematic analysis was then conducted. All authors open-coded a subset of interviews to develop a codebook, which was then used to code the remaining transcripts...
May 1, 2024: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
#12
Matt J Dunn, Robert G Alexander, Onyekachukwu M Amiebenomo, Gemma Arblaster, Denize Atan, Jonathan T Erichsen, Ulrich Ettinger, Mario E Giardini, Iain D Gilchrist, Ruth Hamilton, Roy S Hessels, Scott Hodgins, Ignace T C Hooge, Brooke S Jackson, Helena Lee, Stephen L Macknik, Susana Martinez-Conde, Lee Mcilreavy, Lisa M Muratori, Diederick C Niehorster, Marcus Nyström, Jorge Otero-Millan, Michael M Schlüssel, Jay E Self, Tarkeshwar Singh, Nikolaos Smyrnis, Andreas Sprenger
No abstract text is available yet for this article.
April 30, 2024: Behavior Research Methods
#13
JOURNAL ARTICLE
Benjamin Hu, Brooke E Howitt, Stephanie Cizek, Elisabeth Diver, Susan Hiniker, Jacquelyn Crane, Heike Daldrup-Link, Sheri L Spunt
High-grade endometrial stromal sarcoma is a rare and aggressive soft tissue tumor characterized by YWHAE::NUTM2A/B translocations, diagnosis at a median of 50-60 years, and a poor prognosis (overall survival 30%-40%). We describe a 16-year-old patient with high-grade endometrial stromal sarcoma and regional nodal and pulmonary metastases who is a long-term survivor after grossly complete tumor resection, intensive chemotherapy, and pelvic radiotherapy. We discovered a previously undescribed YWHAE::NUTM2E translocation in the tumor...
April 26, 2024: Journal of Pediatric Hematology/oncology
#14
JOURNAL ARTICLE
Emma Timmins-Schiffman, Amy E Maas, Rayhan Khanna, Leocadio Blanco-Bercial, Eric Huang, Brook L Nunn
Diel rhythms are observed across taxa and are important for maintaining synchrony between the environment and organismal physiology. A striking example of this is the diel vertical migration undertaken by zooplankton, some of which, such as the 5 mm-long copepod Pleuromamma xiphias ( P. xiphias ), migrate hundreds of meters daily between the surface ocean and deeper waters. Some of the molecular pathways that underlie the expressed phenotype at different stages of this migration are entrained by environmental variables (e...
May 1, 2024: Journal of Proteome Research
#15
Alyssa C Flint, Dana K Mitchell, Steven P Angus, Abbi E Smith, Waylan Bessler, Li Jiang, Henry Mang, Xiaohong Li, Qingbo Lu, Brooke Rodriguez, George E Sandusky, Andi R Masters, Chi Zhang, Pengtao Dang, Jenna Koenig, Gary L Johnson, Weihua Shen, Jiangang Liu, Amit Aggarwal, Gregory P Donoho, Melinda D Willard, Shripad V Bhagwat, D Wade Clapp, Steven D Rhodes
No abstract text is available yet for this article.
May 1, 2024: Clinical Cancer Research
#16
JOURNAL ARTICLE
Promil Kukreja, Kevin O'keefe, Jacelyn E Peabody Lever, Hanna Hussey, Paul D Piennette, Brooke Vining, Peter Nagi, Roland T Short, Scott Mabry, Hari Kalagara
Introduction Quadratus lumborum (QL) block has previously been shown to provide improved analgesia in patients undergoing primary total hip arthroplasty (THA) under spinal anesthesia when compared to spinal anesthesia alone. Additionally, recent studies have shown the addition of intrathecal morphine (ITM) to provide superior postoperative analgesia in patients undergoing various surgical interventions including total knee arthroplasty under spinal anesthesia with peripheral nerve blockade. At this time, however, there has not been a study evaluating the effects of intrathecal morphine in patients undergoing THA under spinal anesthesia with QL block...
March 2024: Curēus
#17
JOURNAL ARTICLE
Skylar J Brooks, Catherine Stamoulis
Functional interactions and anatomic connections between brain regions form the connectome. Its mathematical representation in terms of a graph reflects the inherent neuroanatomical organization into structures and regions (nodes) that are interconnected through neural fiber tracts and/or interact functionally (edges). Without knowledge of the ground truth topology of the connectome, functional (directional or nondirectional) graphs represent estimates of signal correlations, from which underlying mechanisms and processes, such as development and aging, or neuropathologies, are difficult to unravel...
June 2023: IEEE ICASSPW 2023 Workshop Proc ICASSP 2023 (2023)
#18
JOURNAL ARTICLE
Kiley Nelson, Melissa Brooks, Carolyn Mead-Harvey, Janae Quill, Brigid Kiley, Charles Peworski, Adrienne Ritchie, Ayan Sen
OBJECTIVE: We describe the creation of a two-tier emergency response system with a nurse-led first responder program titled "MET-RN" (Medical Emergency Team-Registered Nurse) created for ambulatory settings supported by a critical care code blue team for escalation of care. This observational study evaluated the clinical characteristics and effects of a MET-RN program on the code blue response. METHODS: A retrospective review of the MET-RN response data was assessed from January 2016 to June 2021...
June 2024: Resuscitation plus
#19
David J Eldridge, Jingyi Ding, Josh Dorrough, Manuel Delgado-Baquerizo, Osvaldo Sala, Nicolas Gross, Yoann Le Bagousse-Pinguet, Max Mallen-Cooper, Hugo Saiz, Sergio Asensio, Victoria Ochoa, Beatriz Gozalo, Emilio Guirado, Miguel García-Gómez, Enrique Valencia, Jaime Martínez-Valderrama, César Plaza, Mehdi Abedi, Negar Ahmadian, Rodrigo J Ahumada, Julio M Alcántara, Fateh Amghar, Luísa Azevedo, Farah Ben Salem, Miguel Berdugo, Niels Blaum, Bazartseren Boldgiv, Matthew Bowker, Donaldo Bran, Chongfeng Bu, Rafaella Canessa, Andrea P Castillo-Monroy, Ignacio Castro, Patricio Castro-Quezada, Simone Cesarz, Roukaya Chibani, Abel Augusto Conceição, Anthony Darrouzet-Nardi, Yvonne C Davila, Balázs Deák, Paloma Díaz-Martínez, David A Donoso, Andrew David Dougill, Jorge Durán, Nico Eisenhauer, Hamid Ejtehadi, Carlos Ivan Espinosa, Alex Fajardo, Mohammad Farzam, Ana Foronda, Jorgelina Franzese, Lauchlan H Fraser, Juan Gaitán, Katja Geissler, Sofía Laura Gonzalez, Elizabeth Gusman-Montalvan, Rosa Mary Hernández, Norbert Hölzel, Frederic Mendes Hughes, Oswaldo Jadan, Anke Jentsch, Mengchen Ju, Kudzai F Kaseke, Melanie Köbel, Anika Lehmann, Pierre Liancourt, Anja Linstädter, Michelle A Louw, Quanhui Ma, Mancha Mabaso, Gillian Maggs-Kölling, Thulani P Makhalanyane, Oumarou Malam Issa, Eugene Marais, Mitchel McClaran, Betty Mendoza, Vincent Mokoka, Juan P Mora, Gerardo Moreno, Seth Munson, Alice Nunes, Gabriel Oliva, Gastón R Oñatibia, Brooke Osborne, Guadalupe Peter, Margerie Pierre, Yolanda Pueyo, R Emiliano Quiroga, Sasha Reed, Ana Rey, Pedro Rey, Víctor Manuel Reyes Gómez, Víctor Rolo, Matthias C Rillig, Peter C le Roux, Jan Christian Ruppert, Ayman Salah, Phokgedi Julius Sebei, Anarmaa Sharkhuu, Ilan Stavi, Colton Stephens, Alberto L Teixido, Andrew David Thomas, Katja Tielbörger, Silvia Torres Robles, Samantha Travers, Orsolya Valkó, Liesbeth van den Brink, Frederike Velbert, Andreas von Heßberg, Wanyoike Wamiti, Deli Wang, Lixin Wang, Glenda M Wardle, Laura Yahdjian, Eli Zaady, Yuanming Zhang, Xiaobing Zhou, Fernando T Maestre
No abstract text is available yet for this article.
April 30, 2024: Nature Plants
#20
JOURNAL ARTICLE
Alastair J McGinness, Susan A Brooks, Richard Strasser, Jennifer Schoberer, Verena Kriechbaumer
Plant cells are a capable system for producing economically and therapeutically important proteins for a variety of applications, and are considered a safer production system than some existing hosts such as bacteria or yeasts. However, plants do not perform protein modifications in the same manner as mammalian cells do. This can impact on protein functionality for plant-produced human therapeutics. This obstacle can be overcome by creating a plant-based system capable of 'humanising' proteins of interest resulting in a glycosylation profile of synthetic plant-produced proteins as it would occur in mammalian systems...
April 30, 2024: Journal of Microscopy
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