Kaiping Burrows, Leandra K Figueroa-Hall, Jennifer L Stewart, Ahlam M Alarbi, Rayus Kuplicki, Bethany N Hannafon, Chibing Tan, Victoria B Risbrough, Brett A McKinney, Rajagopal Ramesh, Teresa A Victor, Robin Aupperle, Jonathan Savitz, T Kent Teague, Sahib S Khalsa, Martin P Paulus
Major depressive disorder (MDD) is associated with interoceptive processing dysfunctions, but the molecular mechanisms underlying this dysfunction are poorly understood. This study combined brain neuronal-enriched extracellular vesicle (NEEV) technology and serum markers of inflammation and metabolism with Functional Magnetic Resonance Imaging (fMRI) to identify the contribution of gene regulatory pathways, in particular micro-RNA (miR) 93, to interoceptive dysfunction in MDD. Individuals with MDD (n = 41) and healthy comparisons (HC; n = 35) provided blood samples and completed an interoceptive attention task during fMRI...
April 27, 2024: Translational Psychiatry