Tang Zhu, Joseph A Mancini, Przemyslaw Sapieha, Chun Yang, Jean-Sébastien Joyal, Jean-Claude Honoré, Martin Leduc, Karine Zaniolo, Pierre Hardy, Zhuo Shao, Li Fan, Xin Hou, Georges-Etienne Rivard, Sylvain Chemtob
Cellular migration is a complex process that requires the polymerization of actin filaments to drive cellular extension. Smooth muscle and cancer cell migration has been shown to be affected by coagulation factors, notably the factor VII (FVIIa) and tissue factor (TF) complex. The present studies delineated mediators involved with the process of FVIIa/TF-induced cell migration and utilized a simple, precise, and reproducible, migration assay. Both FVIIa and protease-activated receptor-2 (PAR2)-activating peptide, SLIGRL, increased the migration rate of porcine cerebral microvascular endothelial cells (pCMVECs) overexpressing human TF...
March 2011: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology