Liang Su, Yan Chen, Ming Fu, Hezhen Wang, Yanlu Tong, Zefeng Lin, Hongjiao Chen, Huiting Lin, Yi Chen, Bing Zhu, Sige Ma, Yiyi Xiao, Junyu Huang, Ziyang Zhao, Fenjie Li, Rongchen Ye, Hongguang Shi, Zhe Wang, Jixiao Zeng, Zhe Wen, Minhua Luo, Huimin Xia, Ruizhong Zhang
BACKGROUND & AIMS: A high human cytomegalovirus (HCMV) infection rate accompanied by an increased level of bile duct damage is observed in the perinatal period. The possible mechanism was investigated. METHODS: A total of 1,120 HCMV-positive and 9,297 HCMV-negative children were recruited, and depending on age, their liver biochemistry profile was compared. Fetal and infant biliary epithelial cells (F-BECs and I-BECs, respectively) were infected with HCMV, and the differences in cells were revealed by proteomic analysis...
May 2024: JHEP reports: innovation in hepatology