A J Leach, N Wilson, B Arrowsmith, J Beissbarth, E K Mulholland, M Santosham, P J Torzillo, P McIntyre, H Smith-Vaughan, S A Skull, V M Oguoma, M Chatfield, D Lehmann, M J Binks, P V Licciardi, R Andrews, T Snelling, V Krause, J Carapetis, A B Chang, P S Morris
OBJECTIVES: In remote communities of northern Australia, First Nations children with hearing loss are disproportionately at risk of poor school readiness and performance compared to their peers with no hearing loss. The aim of this trial is to prevent early childhood persisting otitis media (OM), associated hearing loss and developmental delay. To achieve this, we designed a mixed pneumococcal conjugate vaccine (PCV) schedule that could maximise immunogenicity and thereby prevent bacterial otitis media (OM) and a trajectory of educational and social disadvantage...
December 2023: International Journal of Pediatric Otorhinolaryngology