Marcia Consentino Kronka Sosthenes, Daniel Guerreiro Diniz, Jay Roodselaar, Ricardo Abadie-Guedes, Fabíola de Carvalho Chaves de Siqueira Mendes, Taiany Nogueira Fernandes, Jackson Cioni Bittencourt, Cristovam Wanderley Picanço Diniz, Daniel Clive Anthony, Rubem Carlos Araújo Guedes
Early growth response-1 (Egr-1), defined as a zinc finger transcription factor, is an upstream master switch of the inflammatory response, and its expression can be used to investigate the spatial and temporal extent of inflammatory changes in the brain. Cortical spreading depression (CSD) is characterized as a slowly propagating (2-5 mm/min) depolarization wave through neurons and astrocytes in humans that contributes to migraines and possibly to other brain pathologies. In rodents, CSD can be induced experimentally, which involves unilateral depolarization that is associated with microglial and astrocyte responses...
2019: Frontiers in Neuroscience