Ana Karoline Vieira Melo, Danielle da Nóbrega Alves, Palloma Christine Queiroga Gomes da Costa, Susiany Pereira Lopes, Damião Pergentino de Sousa, Felipe Queiroga Sarmento Guerra, Marianna Vieira Sobral, Ana Paula Gomes Moura, Luciana Scotti, Ricardo Dias de Castro
Fungal infections represent a serious health problem worldwide. The study evaluated the antifungal activity of 4-chlorobenzyl p-coumarate, an unprecedented semi-synthetic molecule. Docking molecular and assay experiments were conducted to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC), mode of action, effect on growth, fungal death kinetics, drug association, effects on biofilm, micromorphology, and against human keratinocytes. The investigation included 16 strains of Candida spp, including C...
May 3, 2024: Chemistry & Biodiversity