David Ascheid, Magdalena Baumann, Jürgen Pinnecker, Mike Friedrich, Daniel Szi-Marton, Cornelia Medved, Maja Bundalo, Vanessa Ortmann, Asli Öztürk, Rajender Nandigama, Katherina Hemmen, Süleymann Ergün, Alma Zernecke, Matthias Hirth, Katrin G Heinze, Erik Henke
Targeting the supportive tumor microenvironment (TME) is an approach of high interest in cancer drug development. However, assessing TME-targeted drug candidates presents a unique set of challenges. We develop a comprehensive screening platform that allows monitoring, quantifying, and ranking drug-induced effects in self-organizing, vascularized tumor spheroids (VTSs). The confrontation of four human-derived cell populations makes it possible to recreate and study complex changes in TME composition and cell-cell interaction...
April 27, 2024: Nature Communications