Julia Romanowska, Haakon E Nustad, Christian M Page, William R P Denault, Yunsung Lee, Maria C Magnus, Kristine L Haftorn, Miriam Gjerdevik, Boris Novakovic, Richard Saffery, Håkon K Gjessing, Robert Lyle, Per Magnus, Siri E Håberg, Astanand Jugessur
BACKGROUND: Assisted reproductive technologies (ART) may perturb DNA methylation (DNAm) in early embryonic development. Although a handful of epigenome-wide association studies of ART have been published, none have investigated CpGs on the X chromosome. To bridge this knowledge gap, we leveraged one of the largest collections of mother-father-newborn trios of ART and non-ART (natural) conceptions to date to investigate sex-specific DNAm differences on the X chromosome. The discovery cohort consisted of 982 ART and 963 non-ART trios from the Norwegian Mother, Father, and Child Cohort Study (MoBa)...
April 21, 2023: Human Genomics