Pranay Shah, Ross Hill, Camille Dion, Stephen J Clark, Abdulkadir Abakir, Jeroen Willems, Mark J Arends, Juan I Garaycoechea, Harry G Leitch, Wolf Reik, Gerry P Crossan
Mutations in DNA damage response (DDR) factors are associated with human infertility, which affects up to 15% of the population. The DDR is required during germ cell development and meiosis. One pathway implicated in human fertility is DNA translesion synthesis (TLS), which allows replication impediments to be bypassed. We find that TLS is essential for pre-meiotic germ cell development in the embryo. Loss of the central TLS component, REV1, significantly inhibits the induction of human PGC-like cells (hPGCLCs)...
May 3, 2024: Nature Communications