Daisuke Toritsuka, Masaya Aoki, Akihiko Higashida, Kazuaki Fukahara, Naonori Nishida, Keiichi Hirono, Mai Hane, Takuya Sugimoto, Takashi Asahara, Naoki Yoshimura
OBJECTIVES: Intestinal ischemia-reperfusion injury induced by cardiopulmonary bypass causes intestinal epithelial barrier dysfunction, leading to dysbiosis and bacterial translocation. We conducted a randomized prospective study with two objectives: (1) to investigate epithelial barrier dysfunction and bacterial translocation induced by cardiopulmonary bypass and changes in the gut microbiota and (2) to verify whether probiotics can improve these conditions. METHODS: Between 2019 and 2020, patients 0-15 years old scheduled to undergo cardiac surgery using cardiopulmonary bypass were enrolled and randomly allocated to 2 groups: the intervention group received probiotics, and the control group did not receive probiotics...
April 10, 2024: European Journal of Cardio-thoracic Surgery