Takeshi Yoshimoto, Hiroyuki Ishiyama, Yorito Hattori, Kunihiro Nishimura, Yoko Okada, Hideaki Watanabe, Yasumasa Ohyagi, Yasuhisa Akaiwa, Tomoyuki Miyamoto, Michi Kawamoto, Masahiko Ichijo, Hiroyasu Inoue, Noriyuki Matsukawa, Toshiki Mizuno, Hirofumi Matsuyama, Hidekazu Tomimoto, Daisuke Kawakami, Kazunori Toyoda, Masatoshi Koga, Masafumi Ihara
BACKGROUND AND AIMS: RNF213 is a susceptibility gene for moyamoya disease and vasospastic angina, with a second hit considered necessary for their development. Elevated thyroid peroxidase antibody (TPO-Ab) levels have been observed in both diseases, suggesting a possible role of TPO-Ab as a second hit for developing RNF213-related vasculopathy. We investigated the association of TPO-Ab levels with RNF213-related ischemic stroke (IS)/transient ischemic attack (TIA), other than moyamoya disease...
September 12, 2023: Atherosclerosis