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JOURNAL ARTICLE
Gang Li, Yapeng Lin, Jie Yang, Craig S Anderson, Chen Chen, Feifeng Liu, Laurent Billot, Qiang Li, Xiaoying Chen, Xiaoqiu Liu, Xinwen Ren, Chunfang Zhang, Ping Xu, Lijun Wu, Feng Wang, Daijun Qiu, Mei Jiang, Yiqian Peng, Chaohui Li, Yiyang Huang, Xiaohui Zhao, Jiye Liang, Yao Wang, Xiangjun Wu, Xiaoyun Xu, Guofang Chen, Dongya Huang, Yue Zhang, Lian Zuo, Guozhao Ma, Yumei Yang, Junjie Hao, Xiahong Xu, Xinli Xiong, Yueyu Tang, Yijia Guo, Jianping Yu, Shuping Li, Song He, Fengkai Mao, Quandan Tan, Song Tan, Nengwei Yu, Ruxiang Xu, Mingwei Sun, Binghu Li, Jiang Guo, Leibo Liu, Hueiming Liu, Menglu Ouyang, Lei Si, Hisatomi Arima, Philip M Bath, Gary A Ford, Thompson Robinson, Else Charlotte Sandset, Jeffrey L Saver, Nikola Sprigg, H Bart van der Worp, Lili Song
BACKGROUND: Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. Whether very early blood-pressure control in the ambulance improves outcomes among patients with undifferentiated acute stroke is uncertain. METHODS: We randomly assigned patients with suspected acute stroke that caused a motor deficit and with elevated systolic blood pressure (≥150 mm Hg), who were assessed in the ambulance within 2 hours after the onset of symptoms, to receive immediate treatment to lower the systolic blood pressure (target range, 130 to 140 mm Hg) (intervention group) or usual blood-pressure management (usual-care group)...
May 16, 2024: New England Journal of Medicine
#42
JOURNAL ARTICLE
Emma Christensen, Helge Fagerheim Bugge, Jostein Hagemo, Karianne Larsen, Astrid Kv Harring, Jostein Gleditsch, Jørgen Ibsen, Mona Guterud, Else Charlotte Sandset, Maren Ranhoff Hov
INTRODUCTION: The optimal pathway for ultra-early diagnostics and treatment in patients with acute stroke remains uncertain. The aim of this study was to investigate how three different methods of simulated, rural prehospital computed tomography (CT) affected the time to prehospital treatment decision in acute stroke. MATERIALS AND METHODS: In this pragmatic, simulation, pilot study of prehospital CT we investigated a conventional ambulance with transport to a standard care rural stationary CT machine managed by paramedics, a Mobile Stroke Unit (MSU), and a helicopter with a simulated CT machine...
May 16, 2024: European Stroke Journal
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JOURNAL ARTICLE
Johan Van der Heyden, Victoria Leclercq, Els Duysburgh, Laura Cornelissen, Isabelle Desombere, Inge Roukaerts, Lydia Gisle
BACKGROUND: This study assessed seroprevalence trends of SARS-CoV-2 antibodies in the Belgian adult population between March 2021 and April 2022, and explored factors associated with seropositivity and seroreversion among the vaccinated and unvaccinated population. METHODS: A prospective longitudinal surveillance study was conducted within a random sample of the general population (18 + years) in Belgium, selected from the national register through a multistage sampling design...
May 15, 2024: Archives of Public Health, Archives Belges de Santé Publique
#44
JOURNAL ARTICLE
Nicholas Colgrove, Daniel Rodger
Anna Smajdor and Joona Räsänen argue that we have good reason to classify pregnancy as a disease. They discuss five accounts of disease and argue that each account either implies that pregnancy is a disease or if it does not, it faces problems. This strategy allows Smajdor and Räsänen to avoid articulating their own account of disease. Consequently, they cannot establish that pregnancy is a disease, only that plausible accounts of disease suggest this. Some readers will dismiss Smajdor and Räsänen's claims as counterintuitive...
May 15, 2024: Journal of Medical Ethics
#45
JOURNAL ARTICLE
Jiyeon Kim, Sorin C Popescu, Roel R Lopez, X Ben Wu, Nova J Silvy
Numerous unique flora and fauna inhabit the Lower Florida Keys, including the endangered Florida Key deer, found nowhere else. In this vulnerable habitat of flat islands with low elevation, accelerated sea level rise poses a threat. Predicting the impact of sea level rise on vegetation and wildlife is crucial. This study used 5 Intergovernmental Panel on Climate Change (IPCC) sea level rise scenarios to assess their effects on No Name Key, Florida. The goal was to estimate changes in the Florida Key deer population relative to sea level rise using a lidar-derived elevation data and a vegetation map...
May 14, 2024: Journal of Environmental Management
#46
RANDOMIZED CONTROLLED TRIAL
Stuart J Connolly, Mukul Sharma, Alexander T Cohen, Andrew M Demchuk, Anna Członkowska, Arne G Lindgren, Carlos A Molina, Daniel Bereczki, Danilo Toni, David J Seiffge, David Tanne, Else Charlotte Sandset, Georgios Tsivgoulis, Hanne Christensen, Jan Beyer-Westendorf, Jonathan M Coutinho, Mark Crowther, Peter Verhamme, Pierre Amarenco, Risto O Roine, Robert Mikulik, Robin Lemmens, Roland Veltkamp, Saskia Middeldorp, Thompson G Robinson, Truman John Milling, Vitor Tedim-Cruz, Wilfried Lang, Anders Himmelmann, Per Ladenvall, Mikael Knutsson, Ella Ekholm, Andrew Law, Amanda Taylor, Tetyana Karyakina, Lizhen Xu, Kate Tsiplova, Sven Poli, Bernd Kallmünzer, Christoph Gumbinger, Ashkan Shoamanesh
BACKGROUND: Patients with acute intracerebral hemorrhage who are receiving factor Xa inhibitors have a risk of hematoma expansion. The effect of andexanet alfa, an agent that reverses the effects of factor Xa inhibitors, on hematoma volume expansion has not been well studied. METHODS: We randomly assigned, in a 1:1 ratio, patients who had taken factor Xa inhibitors within 15 hours before having an acute intracerebral hemorrhage to receive andexanet or usual care...
May 16, 2024: New England Journal of Medicine
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JOURNAL ARTICLE
Mohammadali Dashtbali, Jonathan M Henshaw
In the 1980s, groundbreaking theoretical studies showed that orna- ments displayed during courtship can coevolve with preferences for such ornaments, leading to extreme exaggeration of both traits. Later mod- els cast doubt on such 'runaway' sexual selection, showing that even a small cost of preferences can prevent exaggerated ornaments from per- sisting long-term. It was subsequently shown that if mutations acting on the ornament are biased - tending to produce smaller rather than larger ornaments - then exaggeration can persist even in the presence of pref- erence costs, seemingly vindicating the original models...
May 15, 2024: Evolution; International Journal of Organic Evolution
#48
JOURNAL ARTICLE
Lukas Egli, Meike Kaulfuss, Juliane Mietz, Arianna Picozzi, Els Verhoeyen, Christian Münz, Obinna Chijioke
BACKGROUND: CAR NK cells as vehicles for engineered "off-the-shelf" cellular cancer immunotherapy have attracted significant interest. Nonetheless, a comprehensive comparative assessment of the anticancer activity of CAR T cells and CAR NK cells carrying approved benchmark anti-CD19 CAR constructs is missing. Here, we report a direct head-to-head comparison of CD19-directed human T and NK cells. METHODS: We generated CAR T and CAR NK cells derived from healthy donor PBMC by retroviral transduction with the same benchmark second-generation anti-CD19 CAR construct, FMC63...
May 14, 2024: Experimental Hematology & Oncology
#49
JOURNAL ARTICLE
Dylan E Kirsch, Erica N Grodin, Steven J Nieto, Annabel Kady, Lara A Ray
Early life stress (ELS) increases risk for psychiatric illness, including alcohol use disorder (AUD). Researchers have hypothesized that individuals with and without a history of ELS who have the same primary DSM-5 diagnosis are clinically and biologically distinct. While there is strong support for this hypothesis in the context of mood disorders, the hypothesis remains largely untested in the context of AUD. This study investigated the impact of ELS on the neuroclinical phenomenology and inflammatory profile of individuals with AUD...
May 13, 2024: Neuropsychopharmacology
#50
JOURNAL ARTICLE
Silje M Ormhaug, Ingeborg Skjærvø, Gunvor M Dyrdal, Else Merete Fagermoen, Kristin J Haabrekke, Tine K Jensen, Marie L Knutsen, Anders Næss, Heidi Maria Päivärinne, Marianne Martinsen
Stepping Together for Children after Trauma (ST-CT) is the first step of the promising intervention Stepped Care CBT for Children after Trauma. In ST-CT, the task of leading treatment is partially shifted to the parents, and the child and parent work together to complete therapeutic tasks from a workbook with therapist supervision. We aimed to investigate the feasibility of ST-CT in Norwegian first line services and explore child factors predicting outcome. Eighty-two children (mean age 9.9 years, 56% girls) participated...
May 13, 2024: Research on child and adolescent psychopathology
#51
JOURNAL ARTICLE
Alessandro Sayed, Massimo Cametti
Bispidine based Hg(II) coordination polymers of helical topology CP-MeOH and CP-EtOH are almost isostructural (they mainly differ for the solvent included in their lattice and by a small % in unit cell parameters) but they differ for everything else: i) their intrinsic stability, ii) their ability to adsorb solvents upon prior evacuation, iii) their accessible structural transformations. In particular, one of the two starting materials, once evacuated, is capable to adsorb methanol from atmospheres containing binary and ternary mixtures of volatile organic compounds (MeOH, CHCl3 and EtOH) under ambient conditions (25 °C, 1 atm) and with a marked selectivity...
May 13, 2024: Chemistry: a European Journal
#52
JOURNAL ARTICLE
Clarissa Caroli, Giovanna Baron, Giorgio Cappellucci, Virginia Brighenti, Larissa Della Vedova, Francesca Fraulini, Simonetta Oliaro-Bosso, Andrea Alessandrini, Alfonso Zambon, Gigliola Lusvardi, Giancarlo Aldini, Marco Biagi, Lorenzo Corsi, Federica Pellati
Policosanols (PCs) are bioactive compounds extracted from different natural waxes. In this work, the purification, characterization and assessment of the antioxidant and anti-inflammatory activity was carried out on PCs from an innovative source, i.e. a waxy material from supercritical-fluid extraction (SFE) of non-psychoactive Cannabis sativa L. (hemp) inflorescences. Starting from this material, PCs were obtained by microwave-assisted trans -esterification and hydrolysis, followed by preparative liquid chromatography under normal phase conditions...
May 15, 2024: Heliyon
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JOURNAL ARTICLE
Andreas Capiau, Els Mehuys, Maxim Grymonprez, Inge Van Tongelen, Thierry Christiaens, Eline Tommelein, Geneviève Philippe, Lies Lahousse, Tine De Backer, Koen Boussery
INTRODUCTION: Direct oral anticoagulants (DOACs) are increasingly used and can be involved in clinically relevant drug-drug interactions (DDIs) that increase the risk of major bleeding or thromboembolism. Skilled drug interaction management is essential to ensure safe and effective use of DOACs. In this study, we aimed to investigate the impact of the detection and management of DDIs with DOACs in a real-life community pharmacy setting on the pharmacotherapy of DOAC users. METHODS: We conducted an intervention study in 201 community pharmacies in Belgium...
May 7, 2024: Thrombosis Research
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JOURNAL ARTICLE
Maroua Grira, Els Prinsen, Stefaan Werbrouck
Topolin cytokinins have emerged as valuable tools in micropropagation. This study investigates the metabolism of meta-topolin riboside (mTR) in three distinct tree species: Handroanthus guayacan and Tabebuia rosea ( Bignoniaceae ), and Tectona grandis ( Lamiaceae ). Employing labeled N15 mTR, we unraveled the complex mechanisms underlying cytokinin homeostasis, identifying N9-glucosylation as the principal deactivation pathway. Our findings demonstrate a capacity in T. rosea and H. guayacan to reposition the hydroxyl group on the cytokinin molecule, a previously unexplored metabolic pathway...
May 6, 2024: Plants (Basel, Switzerland)
#55
JOURNAL ARTICLE
Mbavhalelo C Molewa, Agata Ogonowski-Bizos, Mariska Els, Cheryl M Birtles, Molebogeng C Kolojane
BACKGROUND: Necrotising fasciitis (NF) is a fulminant soft tissue infection that requires timely diagnosis, urgent surgical debridement, and appropriate antimicrobial therapy. The choice of empiric antimicrobial therapy depends on the microorganisms cultured and the antimicrobial resistance profile of the institution. Necrotising fasciitis has not been studied in our setting. OBJECTIVES: The aim of the study was to audit the microbiological profile of NF and antimicrobial susceptibility profile...
2024: Southern African Journal of Infectious Diseases
#56
JOURNAL ARTICLE
Cor-Jacques Kat, Roland Peter Gräbe, Paul Jacobus van Staden, Tanita Botha, Pieter Schalk Els
Not only is it important to know how large the overall change in vibration should be for occupants to perceive an improvement in comfort, but also how large this change should be in specific frequency bands. Relative difference thresholds (RDT) of primary (0.5-4 Hz) and secondary (9-80 Hz) ride are estimated for 14 automotive engineers seated in a vehicle on a 4-poster test rig over two roads. Resulting stimuli differed in magnitude and spectral shape. The median RDTs estimated for primary and secondary ride were 16...
May 10, 2024: Ergonomics
#57
JOURNAL ARTICLE
Thiago Doria Rego, Juliana Rezende Montenegro Medeiros de Moraes, Ivone Evangelista Cabral, Tania Vignuda de Souza
BACKGROUND: Self-care refers to the ability that an individual has or develops to regulate the functioning of the body. Health status and age are factors associated with dependency on, and the need for, someone else to take over self-care. In the present case, there was a self-care deficit. Cystic fibrosis is a chronic disease that occurs in one in 10,000 live births in Brazil, and the affected population in the country is predominantly pediatric (approximately 73%). Support from nursing teams is necessary to improve patients' skills until they can take full responsibility for their self-care...
May 8, 2024: Journal of Pediatric Nursing
#58
JOURNAL ARTICLE
Felix Beuschlein, Tobias Else, Irina Bancos, Stefanie Hahner, Oksana Hamidi, Leonie van Hulsteijn, Eystein S Husebye, Niki Karavitaki, Alessandro Prete, Anand Vaidya, Christine Yedinak, Olaf M Dekkers
Glucocorticoids are widely prescribed as anti-inflammatory and immunosuppressive agents. This results in at least 1% of the population using chronic glucocorticoid therapy, being at risk for glucocorticoid-induced adrenal insufficiency. This risk is dependent on the dose, duration and potency of the glucocorticoid, route of administration, and individual susceptibility. Once glucocorticoid-induced adrenal insufficiency develops or is suspected, it necessitates careful education and management of affected patients...
May 10, 2024: Journal of Clinical Endocrinology and Metabolism
#59
JOURNAL ARTICLE
Jiao Cheng, Lin Yuan, Shuwen Yu, Bing Gu, Qian Luo, Xixi Wang, Yijing Zhao, Chengcheng Gai, Tingting Li, Weiyang Liu, Zhen Wang, Dexiang Liu, Roger C M Ho, Cyrus S H Ho
Early life stress (ELS) increases the risk of depression later in life. Programmed cell death factor 4 (PDCD4), an apoptosis-related molecule, extensively participates in tumorigenesis and inflammatory diseases. However, its involvement in a person's susceptibility to ELS-related depression is unknown. To examine the effects and underlying mechanisms of PDCD4 on ELS vulnerability, we used a "two-hit" stress mouse model: an intraperitoneal injection of lipopolysaccharide (LPS) into neonatal mice was performed on postnatal days 7-9 (P7-P9) and inescapable foot shock (IFS) administration in adolescent was used as a later-life challenge...
May 7, 2024: Behavioural Brain Research
#60
JOURNAL ARTICLE
Eileen O Dareng, Simon G Coetzee, Jonathan P Tyrer, Pei-Chen Peng, Will Rosenow, Stephanie Chen, Brian D Davis, Felipe Segato Dezem, Ji-Heui Seo, Robbin Nameki, Alberto L Reyes, Katja K H Aben, Hoda Anton-Culver, Natalia N Antonenkova, Gerasimos Aravantinos, Elisa V Bandera, Laura E Beane Freeman, Matthias W Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Marcus Q Bernardini, Line Bjorge, Amanda Black, Natalia V Bogdanova, Kelly L Bolton, James D Brenton, Agnieszka Budzilowska, Ralf Butzow, Hui Cai, Ian Campbell, Rikki Cannioto, Jenny Chang-Claude, Stephen J Chanock, Kexin Chen, Georgia Chenevix-Trench, Yoke-Eng Chiew, Linda S Cook, Anna DeFazio, Joe Dennis, Jennifer A Doherty, Thilo Dörk, Andreas du Bois, Matthias Dürst, Diana M Eccles, Gabrielle Ene, Peter A Fasching, James M Flanagan, Renée T Fortner, Florentia Fostira, Aleksandra Gentry-Maharaj, Graham G Giles, Marc T Goodman, Jacek Gronwald, Christopher A Haiman, Niclas Håkansson, Florian Heitz, Michelle A T Hildebrandt, Estrid Høgdall, Claus K Høgdall, Ruea-Yea Huang, Allan Jensen, Michael E Jones, Daehee Kang, Beth Y Karlan, Anthony N Karnezis, Linda E Kelemen, Catherine J Kennedy, Elza K Khusnutdinova, Lambertus A Kiemeney, Susanne K Kjaer, Jolanta Kupryjanczyk, Marilyne Labrie, Diether Lambrechts, Melissa C Larson, Nhu D Le, Jenny Lester, Lian Li, Jan Lubiński, Michael Lush, Jeffrey R Marks, Keitaro Matsuo, Taymaa May, John R McLaughlin, Iain A McNeish, Usha Menon, Stacey Missmer, Francesmary Modugno, Melissa Moffitt, Alvaro N Monteiro, Kirsten B Moysich, Steven A Narod, Tu Nguyen-Dumont, Kunle Odunsi, Håkan Olsson, N Charlotte Onland-Moret, Sue K Park, Tanja Pejovic, Jennifer B Permuth, Anna Piskorz, Darya Prokofyeva, Marjorie J Riggan, Harvey A Risch, Cristina Rodríguez-Antona, Mary Anne Rossing, Dale P Sandler, V Wendy Setiawan, Kang Shan, Honglin Song, Melissa C Southey, Helen Steed, Rebecca Sutphen, Anthony J Swerdlow, Soo Hwang Teo, Kathryn L Terry, Pamela J Thompson, Liv Cecilie Vestrheim Thomsen, Linda Titus, Britton Trabert, Ruth Travis, Shelley S Tworoger, Ellen Valen, Els Van Nieuwenhuysen, Digna Velez Edwards, Robert A Vierkant, Penelope M Webb, Clarice R Weinberg, Rayna Matsuno Weise, Nicolas Wentzensen, Emily White, Stacey J Winham, Alicja Wolk, Yin-Ling Woo, Anna H Wu, Li Yan, Drakoulis Yannoukakos, Nur Zeinomar, Wei Zheng, Argyrios Ziogas, Andrew Berchuck, Ellen L Goode, David G Huntsman, Celeste L Pearce, Susan J Ramus, Thomas A Sellers, Matthew L Freedman, Kate Lawrenson, Joellen M Schildkraut, Dennis Hazelett, Jasmine T Plummer, Siddhartha Kar, Michelle R Jones, Paul D P Pharoah, Simon A Gayther
To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases and 105,724 controls of European origin. We identified five histotype-specific EOC risk regions (p value <5 × 10-8 ) and confirmed previously reported associations for 27 risk regions. Conditional analyses identified an additional 11 signals independent of the primary signal at six risk regions (p value <10-5 )...
May 7, 2024: American Journal of Human Genetics
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