Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Nathalie Alépée, Els Adriaens
Currently two OECD adopted defined approaches (DA) for eye hazard identification of non-surfactant liquids exist (OECD TG467). The purpose of the current study was to develop a DA for eye hazard identification according to the three UN GHS categories (Cat.1, Cat. 2, No Cat.) for solid chemicals: the DAS. The DAS combines two test methods described in OECD TG437 and TG492. The DAS was developed based on in-depth statistical analysis of a database on solids for which in vitro and historically curated in vivo Draize eye test data exist...
May 17, 2024: ALTEX
#2
JOURNAL ARTICLE
Hanna L Kassa, S Singh, M Douglas-Jones, Gill Schermbrucker, J De Lange, Frank Phoya, Claire Butters, Carol Hlela, Ashton Coetzee, Ebrahim Banderker, Kate Webb
BACKGROUND: Vitamin C deficiency, or scurvy, is rare but poses risks for children with poor diets, limited resources, or malabsorption issues. It may also be common in children with restrictive or selective dietary habits in children with global developmental delay, autism spectrum disorder, and physical disabilities. Symptoms include fatigue, irritability, joint and muscle pain, joint swellings, edema, swollen gums, easy bruising, and delayed wound healing. Early recognition and prompt intervention are essential to prevent the progression of symptomatic vitamin C deficiency in children...
May 18, 2024: Pediatric Rheumatology Online Journal
#3
REVIEW
Mariam Ali, Ellis S van Etten, Saloua Akoudad, Joanna D Schaafsma, Marieke C Visser, Mahsoem Ali, Charlotte Cordonnier, Else Charlotte Sandset, Catharina J M Klijn, Ynte M Ruigrok, Marieke J H Wermer
Haemorrhagic stroke is a severe condition with poor prognosis. Biological sex influences the risk factors, presentations, treatment, and patient outcomes of intracerebral haemorrhage, aneurysmal subarachnoid haemorrhage, and vascular malformations. Women are usually older at onset of intracerebral haemorrhage compared with men but have an increased risk of aneurysmal subarachnoid haemorrhage as they age. Female-specific factors such as pregnancy, eclampsia or pre-eclampsia, postmenopausal status, and hormone therapy influence a woman's long-term risk of haemorrhagic stroke...
June 2024: Lancet Neurology
#4
JOURNAL ARTICLE
Laura J Else, Laura Dickinson, Stacey Edick, Ashley Zyhowski, Ken Ho, Leslie Meyn, Sujan Dilly-Penchala, Beth Thompson, Victoria Shaw, Saye Khoo, Rhonda M Brand
BACKGROUND: Poor adherence to ART and pre-exposure prophylaxis (PrEP) can impact patient and public health. Point-of-care testing (POCT) may aid monitoring and adherence interventions. OBJECTIVES: We report the pharmacokinetics of tenofovir [dosed as tenofovir disoproxil (TDF) and tenofovir alafenamide (TAF)], emtricitabine (FTC), lamivudine (3TC) and dolutegravir (DTG) in plasma and urine following drug cessation to evaluate adherence targets in urine for POCT...
May 17, 2024: Journal of Antimicrobial Chemotherapy
#5
JOURNAL ARTICLE
Else Ellermann, Ruth Elizabeth Cameron, Serena M Best
Synthetic hydroxyapatite (HA) is a widely studied bioceramic for bone tissue engineering (BTE) due to its similarity to the mineral component of bone. As bone mineral contains various ionic substitutions that play a crucial role in bone metabolism, the bioactivity of HA can be improved by adding small amounts of physiologically relevant ions into its crystal structure, with silicate-substituted HA (Si-HA) showing particularly promising results. Nevertheless, it remains unclear how distinct material characteristics influence the bioactivity due to the intertwined nature of surface properties...
May 17, 2024: Tissue Engineering. Part C, Methods
#6
JOURNAL ARTICLE
Karin E J Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H M Smith, Ashley C W Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J Owens, Simon Newstead, Jan Steyaert, Elisabeth P Carpenter, Stephen J Tucker
Potassium channels of the Two-Pore Domain (K2P) subfamily, KCNK1-KCNK18, play crucial roles in controlling the electrical activity of many different cell types and represent attractive therapeutic targets. However, the identification of highly selective small molecule drugs against these channels has been challenging due to the high degree of structural and functional conservation that exists not only between K2P channels, but across the whole K+ channel superfamily. To address the issue of selectivity, here we generate camelid antibody fragments (nanobodies) against the TREK-2 (KCNK10) K2P K+ channel and identify selective binders including several that directly modulate channel activity...
May 16, 2024: Nature Communications
#7
JOURNAL ARTICLE
Benjamin Caulier, Sandy Joaquina, Pascal Gelebart, Tara Helén Dowling, Fatemeh Kaveh, Moritz Thomas, Luka Tandaric, Patrik Wernhoff, Niveditha Umesh Katyayini, Cara Wogsland, May Eriksen Gjerstad, Yngvar Fløisand, Gunnar Kvalheim, Carsten Marr, Sebastian Kobold, Jorrit M Enserink, Bjørn Tore Gjertsen, Emmet McCormack, Else Marit Inderberg, Sébastien Wälchli
Acute myeloid leukemia (AML) is characterized by the accumulation of immature myeloid cells in the bone marrow and the peripheral blood. Nearly half of the AML patients relapse after standard induction therapy, and new forms of therapy are urgently needed. Chimeric antigen receptor (CAR) T therapy has so far not been successful in AML due to lack of efficacy and safety. Indeed, the most attractive antigen targets are stem cell markers such as CD33 or CD123. We demonstrate that CD37, a mature B cell marker, is expressed in AML samples, and its presence correlates with the European LeukemiaNet (ELN) 2017 risk stratification...
May 8, 2024: Cell reports medicine
#8
JOURNAL ARTICLE
Anastacia Y Kudinova, Meghan J Kulak, Teresa E Daniels, William Lewis-de Los Angeles, Suzanne de la Monte, Karen Jennings Mathis, Quincy M Beck, Laura E Laumann, Audrey R Tyrka
OBJECTIVES: We aimed to characterize the interplay between early life stress (ELS), metabolic syndrome (MetS), and plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of the fibrinolytic system implicated in cardiometabolic diseases. We also examined the understudied intersection of ELS, physical activity and PAI-1. METHODS: Healthy young adults ages 18-40 (N=200; 68% female) were recruited from the community. Participants with ELS (N=118) experienced childhood maltreatment, and the majority (n=92) also experienced childhood parental loss...
May 8, 2024: Psychoneuroendocrinology
#9
JOURNAL ARTICLE
Li-Hsin Ning, Tak-Cheung Hui
PURPOSE: The present study examined whether participants respond to unperturbed parameters while experiencing specific perturbations in auditory feedback. For instance, we aim to determine if speakers adjust voice loudness when only pitch is artificially altered in auditory feedback. This phenomenon is referred to as the "accompanying effect" in the present study. METHOD: Thirty native Mandarin speakers were asked to sustain the vowel /ɛ/ for 3 s while their auditory feedback underwent single shifts in one of the three distinct ways: pitch shift (±100 cents; coded as PT), loudness shift (±6 dB; coded as LD), or first formant (F1) shift (±100 Hz; coded as FM)...
May 16, 2024: Journal of Speech, Language, and Hearing Research: JSLHR
#10
JOURNAL ARTICLE
Roman Rohner, Markus Kneihsl, Martina B Goeldlin, Arsany Hakim, Mattia Branca, Stefanie Abend, Waldo Valenzuela Pinilla, Sabine Fenzl, Beata Rezny-Kasprzak, Daniel Strbian, Sven Trelle, Maurizio Paciaroni, Götz Thomalla, Patrik Michel, Krassen Nedeltchev, Thomas Gattringer, Else C Sandset, Leo Bonati, Diana Aguiar de Sousa, P N Sylaja, George Ntaios, Masatoshi Koga, Zuzana Gdovinova, Robin Lemmens, Natan M Bornstein, Peter Kelly, Mira Katan, Thomas Horvath, Jesse Dawson, Urs Fischer
BACKGROUND: Whether hemorrhagic transformation (HT) modifies the treatment effect of early versus late initiation of direct oral anticoagulation (DOAC) in people with ischemic stroke and atrial fibrillation is unknown. METHODS: This is a post-hoc analysis of the ELAN trial. The primary outcome was a composite of recurrent ischemic stroke, symptomatic intracranial hemorrhage (sICH), major extracranial bleeding, systemic embolism, or vascular death within 30 days...
May 16, 2024: Circulation
#11
JOURNAL ARTICLE
Gang Li, Yapeng Lin, Jie Yang, Craig S Anderson, Chen Chen, Feifeng Liu, Laurent Billot, Qiang Li, Xiaoying Chen, Xiaoqiu Liu, Xinwen Ren, Chunfang Zhang, Ping Xu, Lijun Wu, Feng Wang, Daijun Qiu, Mei Jiang, Yiqian Peng, Chaohui Li, Yiyang Huang, Xiaohui Zhao, Jiye Liang, Yao Wang, Xiangjun Wu, Xiaoyun Xu, Guofang Chen, Dongya Huang, Yue Zhang, Lian Zuo, Guozhao Ma, Yumei Yang, Junjie Hao, Xiahong Xu, Xinli Xiong, Yueyu Tang, Yijia Guo, Jianping Yu, Shuping Li, Song He, Fengkai Mao, Quandan Tan, Song Tan, Nengwei Yu, Ruxiang Xu, Mingwei Sun, Binghu Li, Jiang Guo, Leibo Liu, Hueiming Liu, Menglu Ouyang, Lei Si, Hisatomi Arima, Philip M Bath, Gary A Ford, Thompson Robinson, Else Charlotte Sandset, Jeffrey L Saver, Nikola Sprigg, H Bart van der Worp, Lili Song
BACKGROUND: Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. Whether very early blood-pressure control in the ambulance improves outcomes among patients with undifferentiated acute stroke is uncertain. METHODS: We randomly assigned patients with suspected acute stroke that caused a motor deficit and with elevated systolic blood pressure (≥150 mm Hg), who were assessed in the ambulance within 2 hours after the onset of symptoms, to receive immediate treatment to lower the systolic blood pressure (target range, 130 to 140 mm Hg) (intervention group) or usual blood-pressure management (usual-care group)...
May 16, 2024: New England Journal of Medicine
#12
JOURNAL ARTICLE
Emma Christensen, Helge Fagerheim Bugge, Jostein Hagemo, Karianne Larsen, Astrid Kv Harring, Jostein Gleditsch, Jørgen Ibsen, Mona Guterud, Else Charlotte Sandset, Maren Ranhoff Hov
INTRODUCTION: The optimal pathway for ultra-early diagnostics and treatment in patients with acute stroke remains uncertain. The aim of this study was to investigate how three different methods of simulated, rural prehospital computed tomography (CT) affected the time to prehospital treatment decision in acute stroke. MATERIALS AND METHODS: In this pragmatic, simulation, pilot study of prehospital CT we investigated a conventional ambulance with transport to a standard care rural stationary CT machine managed by paramedics, a Mobile Stroke Unit (MSU), and a helicopter with a simulated CT machine...
May 16, 2024: European Stroke Journal
#13
JOURNAL ARTICLE
Johan Van der Heyden, Victoria Leclercq, Els Duysburgh, Laura Cornelissen, Isabelle Desombere, Inge Roukaerts, Lydia Gisle
BACKGROUND: This study assessed seroprevalence trends of SARS-CoV-2 antibodies in the Belgian adult population between March 2021 and April 2022, and explored factors associated with seropositivity and seroreversion among the vaccinated and unvaccinated population. METHODS: A prospective longitudinal surveillance study was conducted within a random sample of the general population (18 + years) in Belgium, selected from the national register through a multistage sampling design...
May 15, 2024: Archives of Public Health, Archives Belges de Santé Publique
#14
JOURNAL ARTICLE
Nicholas Colgrove, Daniel Rodger
Anna Smajdor and Joona Räsänen argue that we have good reason to classify pregnancy as a disease. They discuss five accounts of disease and argue that each account either implies that pregnancy is a disease or if it does not, it faces problems. This strategy allows Smajdor and Räsänen to avoid articulating their own account of disease. Consequently, they cannot establish that pregnancy is a disease, only that plausible accounts of disease suggest this. Some readers will dismiss Smajdor and Räsänen's claims as counterintuitive...
May 15, 2024: Journal of Medical Ethics
#15
JOURNAL ARTICLE
Jiyeon Kim, Sorin C Popescu, Roel R Lopez, X Ben Wu, Nova J Silvy
Numerous unique flora and fauna inhabit the Lower Florida Keys, including the endangered Florida Key deer, found nowhere else. In this vulnerable habitat of flat islands with low elevation, accelerated sea level rise poses a threat. Predicting the impact of sea level rise on vegetation and wildlife is crucial. This study used 5 Intergovernmental Panel on Climate Change (IPCC) sea level rise scenarios to assess their effects on No Name Key, Florida. The goal was to estimate changes in the Florida Key deer population relative to sea level rise using a lidar-derived elevation data and a vegetation map...
May 14, 2024: Journal of Environmental Management
#16
RANDOMIZED CONTROLLED TRIAL
Stuart J Connolly, Mukul Sharma, Alexander T Cohen, Andrew M Demchuk, Anna Członkowska, Arne G Lindgren, Carlos A Molina, Daniel Bereczki, Danilo Toni, David J Seiffge, David Tanne, Else Charlotte Sandset, Georgios Tsivgoulis, Hanne Christensen, Jan Beyer-Westendorf, Jonathan M Coutinho, Mark Crowther, Peter Verhamme, Pierre Amarenco, Risto O Roine, Robert Mikulik, Robin Lemmens, Roland Veltkamp, Saskia Middeldorp, Thompson G Robinson, Truman John Milling, Vitor Tedim-Cruz, Wilfried Lang, Anders Himmelmann, Per Ladenvall, Mikael Knutsson, Ella Ekholm, Andrew Law, Amanda Taylor, Tetyana Karyakina, Lizhen Xu, Kate Tsiplova, Sven Poli, Bernd Kallmünzer, Christoph Gumbinger, Ashkan Shoamanesh
BACKGROUND: Patients with acute intracerebral hemorrhage who are receiving factor Xa inhibitors have a risk of hematoma expansion. The effect of andexanet alfa, an agent that reverses the effects of factor Xa inhibitors, on hematoma volume expansion has not been well studied. METHODS: We randomly assigned, in a 1:1 ratio, patients who had taken factor Xa inhibitors within 15 hours before having an acute intracerebral hemorrhage to receive andexanet or usual care...
May 16, 2024: New England Journal of Medicine
#17
JOURNAL ARTICLE
Mohammadali Dashtbali, Jonathan M Henshaw
In the 1980s, groundbreaking theoretical studies showed that orna- ments displayed during courtship can coevolve with preferences for such ornaments, leading to extreme exaggeration of both traits. Later mod- els cast doubt on such 'runaway' sexual selection, showing that even a small cost of preferences can prevent exaggerated ornaments from per- sisting long-term. It was subsequently shown that if mutations acting on the ornament are biased - tending to produce smaller rather than larger ornaments - then exaggeration can persist even in the presence of pref- erence costs, seemingly vindicating the original models...
May 15, 2024: Evolution; International Journal of Organic Evolution
#18
JOURNAL ARTICLE
Lukas Egli, Meike Kaulfuss, Juliane Mietz, Arianna Picozzi, Els Verhoeyen, Christian Münz, Obinna Chijioke
BACKGROUND: CAR NK cells as vehicles for engineered "off-the-shelf" cellular cancer immunotherapy have attracted significant interest. Nonetheless, a comprehensive comparative assessment of the anticancer activity of CAR T cells and CAR NK cells carrying approved benchmark anti-CD19 CAR constructs is missing. Here, we report a direct head-to-head comparison of CD19-directed human T and NK cells. METHODS: We generated CAR T and CAR NK cells derived from healthy donor PBMC by retroviral transduction with the same benchmark second-generation anti-CD19 CAR construct, FMC63...
May 14, 2024: Experimental Hematology & Oncology
#19
JOURNAL ARTICLE
Dylan E Kirsch, Erica N Grodin, Steven J Nieto, Annabel Kady, Lara A Ray
Early life stress (ELS) increases risk for psychiatric illness, including alcohol use disorder (AUD). Researchers have hypothesized that individuals with and without a history of ELS who have the same primary DSM-5 diagnosis are clinically and biologically distinct. While there is strong support for this hypothesis in the context of mood disorders, the hypothesis remains largely untested in the context of AUD. This study investigated the impact of ELS on the neuroclinical phenomenology and inflammatory profile of individuals with AUD...
May 13, 2024: Neuropsychopharmacology
#20
JOURNAL ARTICLE
Silje M Ormhaug, Ingeborg Skjærvø, Gunvor M Dyrdal, Else Merete Fagermoen, Kristin J Haabrekke, Tine K Jensen, Marie L Knutsen, Anders Næss, Heidi Maria Päivärinne, Marianne Martinsen
Stepping Together for Children after Trauma (ST-CT) is the first step of the promising intervention Stepped Care CBT for Children after Trauma. In ST-CT, the task of leading treatment is partially shifted to the parents, and the child and parent work together to complete therapeutic tasks from a workbook with therapist supervision. We aimed to investigate the feasibility of ST-CT in Norwegian first line services and explore child factors predicting outcome. Eighty-two children (mean age 9.9 years, 56% girls) participated...
May 13, 2024: Research on child and adolescent psychopathology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
