Yongning Li, Yaru Tian, Miao Xu, Xuemei Qiu, Zhongjian Bao, Miaoying Shi, Fuchang Deng, Yuanyuan Chen, Song Tang, Yi Wan, Xudong Jia, Hui Yang
Male fertility depends on normal pubertal development. Di(2-ethylhexyl) phthalate (DEHP) is a potent antiandrogen chemical, and exposure to DEHP during peripuberty can damage the developing male reproductive system, especially the testis. However, the specific cellular targets and differentiation processes affected by DEHP, which lead to testicular toxicity, remain poorly defined. Herein, we presented the first single-cell transcriptomic profile of the pubertal mouse testis following DEHP exposure. To carry out the experiment, two groups (n = 8 each) of three-week old male mice were orally administered 0...
May 10, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology