Natalie Hernandez, Yuliya Lokhnygina, Megan Elizabeth Ramaker, Olga Ilkayeva, Michael J Muehlbauer, Matthew L Crawford, Russell P Grant, Daniel S Hsia, Nina Jain, James R Bain, Sarah Armstrong, Christopher B Newgard, Michael Freemark, Pinar Gumus Balikcioglu
OBJECTIVES: Insulin resistance is associated with elevations in plasma branched-chain amino acids (BCAAs). BCAAs compete with aromatic amino acids (AAA) including tryptophan for uptake into β-cells. To explore relationships between BCAAs and tryptophan metabolism, adiposity, and glucose tolerance we compared urine metabolites in overweight/obese youth with T2D to those in non-diabetic overweight/obese and lean youth. METHODS: Metabolites were measured in 24-hr and first-morning urine samples of 56 non-diabetic adolescents with overweight/obesity, 42 adolescents with T2D, and 43 lean controls, ages 12-21 yr...
December 8, 2023: Journal of Clinical Endocrinology and Metabolism