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JOURNAL ARTICLE
Vasileios Oikonomou, Grace Smith, Gregory M Constantine, Monica M Schmitt, Elise M N Ferré, Julie C Alejo, Deanna Riley, Dhaneshwar Kumar, Lucas Dos Santos Dias, Joseph Pechacek, Yannis Hadjiyannis, Taura Webb, Bryce A Seifert, Rajarshi Ghosh, Magdalena Walkiewicz, Daniel Martin, Marine Besnard, Brendan D Snarr, Shiva Deljookorani, Chyi-Chia R Lee, Tom DiMaggio, Princess Barber, Lindsey B Rosen, Aristine Cheng, Andre Rastegar, Adriana A de Jesus, Jennifer Stoddard, Hye Sun Kuehn, Timothy J Break, Heidi H Kong, Leslie Castelo-Soccio, Ben Colton, Blake M Warner, David E Kleiner, Martha M Quezado, Jeremy L Davis, Kevin P Fennelly, Kenneth N Olivier, Sergio D Rosenzweig, Anthony F Suffredini, Mark S Anderson, Marc Swidergall, Carole Guillonneau, Luigi D Notarangelo, Raphaela Goldbach-Mansky, Olaf Neth, Maria Teresa Monserrat-Garcia, Justo Valverde-Fernandez, Jose Manuel Lucena, Ana Lucia Gomez-Gila, Angela Garcia Rojas, Mikko R J Seppänen, Jouko Lohi, Matti Hero, Saila Laakso, Paula Klemetti, Vanja Lundberg, Olov Ekwall, Peter Olbrich, Karen K Winer, Behdad Afzali, Niki M Moutsopoulos, Steven M Holland, Theo Heller, Stefania Pittaluga, Michail S Lionakis
BACKGROUND: Autoimmune polyendocrine syndrome type 1 (APS-1) is a life-threatening, autosomal recessive syndrome caused by autoimmune regulator (AIRE) deficiency. In APS-1, self-reactive T cells escape thymic negative selection, infiltrate organs, and drive autoimmune injury. The effector mechanisms governing T-cell-mediated damage in APS-1 remain poorly understood. METHODS: We examined whether APS-1 could be classified as a disease mediated by interferon-γ...
May 30, 2024: New England Journal of Medicine
#2
JOURNAL ARTICLE
Caroline de Jesus Sousa, Joilson Ferreira Batista, Amanda Karoliny Figueredo Brito, Nathália Castelo Branco Barros, Simone Santiago Carvalho de Oliveira, Marta Helena Branquinha, Maria do Socorro Pires E Cruz, Ivete Lopes de Mendonça, André Luis Souza Dos Santos
Leishmaniasis is a neglected tropical disease caused by protozoa parasites from the Leishmania genus. Vertebrate hosts acquire the infection through the bite of a female sandfly, initiating a complex parasite development cycle. Contrary to previous beliefs regarding cats' resistance, these animals have recently been identified as potential reservoirs for leishmaniasis. Clinical symptoms in cats can manifest in diverse forms, including cutaneous, mucocutaneous, and visceral manifestations. The diagnosis of feline leishmaniasis is complicated by nonspecific symptoms and the relatively lower specificity of serological tests...
May 28, 2024: Current Medicinal Chemistry
#3
JOURNAL ARTICLE
Jonathan Vogel, Ralph S Peters, Jesús Selfa, Mar Ferrer-Suay
BACKGROUND: The taxonomy of the hymenopteran parasitoid subfamily Charipinae (Hymenoptera: Cynipoidea: Figitidae) has, until recently, been in a state of chaos. While this situation has improved significantly in recent years, most of the efforts were focused on morphological data of typically old specimens. Here, we present the first integrative approach to describe the diversity of the genus Phaenoglyphis Förster, 1869 from north-western Europe. NEW INFORMATION: For seven (of a total of 17) species, we provide DNA barcode data...
2024: Biodiversity Data Journal
#4
JOURNAL ARTICLE
Tshiunza Mpoyi Chérubin, Kabongo Augustin, Ntalaja Jeff, Mirenge Goert, Metre Guelord, Manuel de Jesus Encarnacion Ramirez, Beltchika Antoine, Maoneo Israël, Mukuetala Pierre, Kisubi Michel, Punga Ziko, Ketani Teddy, Ouhdiri Yassad, Medhi Hakou, Ntsambi Glennie, Nicola Montemurro
BACKGROUND: Hydrocephalus continues to pose significant clinical challenges in neurosurgery. The primary goal of this study is to assess the feasibility of ventriculocisternostomy (VCS) within the provincial city of Kinshasa and Mali to optimize the management of patients afflicted with hydrocephalus. METHODS: This investigation was hosted at two major urban healthcare facilities: the Initiative Plus Hospital Center, positioned in the bustling metropolis of Kinshasa, Democratic Republic of the Congo (DRC), and the Bamako Hospital, Republic of Mali...
April 2024: Curēus
#5
JOURNAL ARTICLE
Laia Ferreres-Serafini, Susana Mª Martín-Orúe, Meritxell Sadurní, Jesús Jiménez, José Antonio Moreno-Muñoz, Lorena Castillejos
A total of ninety-six weaned piglets were assigned to four dietary treatments in a 2 × 2 design. The treatments included: a standard milk formula (CTR); CTR + probiotics (6.4 × 108 cfu L-1 Bifidobacterium longum subsp. infantis CECT 7210 and 1.1 × 108 cfu L-1 Lactobacillus rhamnosus NH001) + prebiotics (galacto-oligosaccharides 4.36 g L-1 and human-milk-oligosaccharide 0.54 g L-1 ) (SYN); CTR + osteopontin (0.43 g L-1 ) (OPN); and CTR + SYN + OPN (CON). Daily records including feed intake, body weight, and clinical signs, were maintained throughout the 15-day trial...
May 29, 2024: Food & Function
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JOURNAL ARTICLE
Gabriela Jiménez-Díaz, Anders Aune, Jesús Elizarrarás-Rivas, Lobke M Gierman, Martina Keitsch, Anna Marcuzzi, Jennifer J Infanti
BACKGROUND: Neonatal jaundice is a common condition that can lead to brain damage and disabilities when severe cases go undetected. Low- and middle-income countries often lack accurate methods for detecting neonatal jaundice and rely on visual assessment, resulting in a higher incidence of adverse consequences. Picterus Jaundice Pro (Picterus JP), an easy-to-use and affordable smartphone-based screening device for the condition, has demonstrated higher accuracy than visual assessment in Norwegian, Philippine and Mexican newborns...
May 28, 2024: BMC Health Services Research
#7
Jesus Fernandez-Sojo, Carmen Azqueta, Elena Valdivia, Lluis Martorell, Laura Medina-Boronat, Nuria Martínez-Llonch, Silvia Torrents, Margarita Codinach, Carme Canals, Izaskun Elorza, Rocio Parody, Rodrigo Martino, Maria Trabazo, Cristina Díaz de Heredia, Christelle Ferra, David Valcárcel, Mónica Linares, Águeda Ancochea, Enric García-Rey, Nadia García-Muñoz, Laura Medina, Nerea Castillo, Enric Carreras, Juliana Villa, Sergio Querol
No abstract text is available yet for this article.
May 28, 2024: Bone Marrow Transplantation
#8
JOURNAL ARTICLE
Joana Gonçalves, Joana D Amaral, Rita Capela, Maria de Jesus Perry, Cláudia Braga, Maria Manuela Gaspar, Fátima M Piedade, Lubertus Bijlsma, Antoni Roig, Sandra N Pinto, Rui Moreira, Pedro Florindo, Cecília M P Rodrigues
Inducing necroptosis in cancer cells has emerged as an effective strategy to overcome drug resistance. However, while organic small molecules have been extensively studied for this purpose, metal-based compounds have received relatively little attention as triggers of necroptosis. The development of ruthenium (II) hybrid compounds, particularly those containing triazene (Ru-TRZ), highlights a novel avenue for modulating necroptotic cell death. Here we show that incorporating a methyltriazene moiety, a known alkylating warhead, confers superior mitochondrial-targeting properties and enhances cell death compared to amide-containing counterparts...
May 28, 2024: Cell Death Discovery
#9
JOURNAL ARTICLE
Schulz Bastian, Euler André, Fernández León Jesús, Kraft Doreen, Käser Yvonne, Thali Michael, Kubik-Huch Rahel A, Niemann Tilo
RATIONALE AND OBJECTIVES: Within global sustainable resource management efforts, reducing healthcare energy consumption is of public concern. This study aims to analyze the energy consumption of three Dual-Energy computed tomography (DECT) scanners and to predict the power consumption based on scan acquisition parameters. MATERIALS AND METHODS: This study consisted of two parts assessing three DECT scanners: one Dual-Source and two Single-Source DECT. In Part A, the energy consumption for various single- and DECT scans with different acquisition parameters using a chest phantom was measured...
May 27, 2024: Academic Radiology
#10
JOURNAL ARTICLE
Ángel Martínez González, Raquel Miguel Toquero, Alba Riobo Gestido, Camila Eugenia Sieiro Peña, Thalía Chantal Rodríguez Castiñeira, Joana Isabel Silva Sousa, Francisco Javier Fraile Amador, Manuella González Nunes, Samuel Rodríguez Zorrilla, Noelia Pena Piñeiro, María Jesús González Villaverde, Diana Milena Ruiz Hernandez, María José Morales Gorria
OBJECTIVE: the aim of our study was to assess the effect of bariatric surgery on obstetric outcomes. MATERIAL AND METHODS: a retrospective cohort study was conducted, including 54 pregnancies post-bariatric surgery and 219 pregnancies in non-operated obese women, from December 2018 to January 2023. Various maternal and obstetric characteristics were evaluated, ranging from baseline data to antepartum, intrapartum, postpartum, and neonatal outcomes. RESULTS: bariatric surgery showed a significant 69 % reduction in the risk of gestational diabetes (GDM) (p = 0...
May 28, 2024: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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JOURNAL ARTICLE
Guadalupe Pastor-Moreno, Lorena Saletti-Cuesta, Jesús Henares-Montiel, María J Escudero-Carretero, Camila Higueras-Callejón, Isabel Ruiz-Pérez
PURPOSE: Women with disabilities are more exposed to violence. The health sector has a key role in all three levels of prevention of violence against women. The objective of this paper was to review the interventions for preventing gender-based violence and reducing its impact on the mental health of women with any form of disability. METHOD: Relevant studies were identified through conducting searches in PubMed, Scopus, CINAHL, PsyInfo, Social Services Abstracts, and PILOTS...
May 28, 2024: Journal of Nursing Scholarship
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JOURNAL ARTICLE
Juan Carlos Borrego-Moreno, María Julieta Cárdenas-de Luna, José Carlos Márquez-Castillo, José Manuel Reyes-Ruiz, Juan Fidel Osuna-Ramos, Moisés León-Juárez, Rosa María Del Ángel, Adrián Rodríguez-Carlos, Bruno Rivas-Santiago, Carlos Noe Farfan-Morales, Ana Cristina García-Herrera, Luis Adrián De Jesús-González
During the COVID-19 pandemic, a considerable proportion of patients developed a severe condition that included respiratory failure, shock, or multiple organ dysfunction. Acute Kidney Injury (AKI) has been recognized as a possible cause of severe COVID-19 development. Given this, this study investigates the occurrence and consequences of AKI in Mexican patients to contribute to better knowledge and management of this problem. Methods : Using a retrospective observational cohort methodology, we investigated 313 cases from a cohort of 1019 patients diagnosed with COVID-19 at the IMSS Zacatecas General Hospital of Zone No...
May 16, 2024: Infectious Disease Reports
#13
JOURNAL ARTICLE
Jesús Cebrino, Silvia Portero de la Cruz
Many people experience intense fear of COVID-19. The purpose of this study was to provide a comprehensive visual overview of the published literature from 2020 to 2022 assessing fear of COVID-19. From 2020 to 2022, we employed the Scopus database to conduct a bibliometric analysis. We used the VOSviewer program to perform the author co-citation analysis, Mapchart to produce a worldwide map, and Wordart to make a word cloud image. From the 1769 records examined, 1654 (93.50%) were articles, with English being the most common language (96...
April 23, 2024: Clinics and Practice
#14
JOURNAL ARTICLE
Jesús Chávez-Reyes, Fernando Saráchaga-Terrazas, Oliver Alejandro Colis-Arenas, Carlos H López-Lariz, Carlos M Villalón, Bruno A Marichal-Cancino
Glyphosate, a widely used herbicide, is linked to a plethora of deleterious effects in both clinical and preclinical studies. Nevertheless, the effects of its main metabolite, aminomethylphosphonic acid (AMPA), whose half-life in soil is even longer than that of glyphosate, have been little explored. On this basis, as a first approach, in this work, we report that intraperitoneal (i.p.) administration of AMPA or glyphosate (at 10, 56, and 100 mg/kg) decreased, to a similar extent, plasma cholinesterase (ChE) activity in acutely exposed rats...
May 7, 2024: Journal of Xenobiotics
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JOURNAL ARTICLE
Marieke De Craemer, Sanne L C Veldman, Liane B Azevedo, Farid Bardid, Jesus Del Pozo Cruz, Elina Engberg, Juel Jarani, Anna Kontsevaya, Marie Löf, Clarice Martins, Hanna Nalecz, Anthony Okely, Mark Tremblay, Fotini Venetsanou, Mehmet Yildiz, John J Reilly
No abstract text is available yet for this article.
April 2024: The Lancet regional health. Europe
#16
JOURNAL ARTICLE
Hatim Boughanem, Jesús Pilo, Libia Alejandra García-Flores, Isabel Arranz, María Ramos-Fernandez, María Ortega-Castan, Ana B Crujeiras, Juan Sandoval, Manuel Macias-Gonzalez
BACKGROUND: Several studies have suggested secreted frizzled-related protein 2 (SFRP2) gene as a potential clinical biomarker in colorectal cancer (CRC). However, its diagnostic role remains unclear. In this study, we aimed to investigate the significance of SFRP2 methylation levels in a large cohort of biological specimens (including blood, adipose and colonic tissues) from patients with CRC, thereby potentially identifying new biomarker utility. METHODS: We examined the expression (by qPCR) and methylation status (by 450 K DNA array and DNA pyrosequencing) of the SFRP2 gene in healthy participants (N = 110, aged as 53...
May 27, 2024: Journal of Translational Medicine
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JOURNAL ARTICLE
Thaís Silva, Eneida Oliveira, Alana Oliveira, André Menezes, Wander de Jesus Jeremias, Rafaella Fq Grenfell, Rubens Lima do Monte-Neto, Marcelo A Pascoal-Xavier, Marco A Campos, Gabriel Fernandes, Pedro Alves
Since the emergence of SARS-CoV-2 in December 2019, more than 12,000 mutations in the virus have been identified. These could cause changes in viral characteristics and directly impact global public health. The emergence of variants is a great concern due to the chance of increased transmissibility and infectivity. Sequencing for surveillance and monitoring circulating strains is extremely necessary as the early identification of new variants allows public health agencies to make faster and more effective decisions to contain the spread of the virus...
May 28, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
#18
JOURNAL ARTICLE
Alma Alejandra Hernández-Esquivel, Jorge Alejandro Torres-Olmos, Manuel Méndez-Gómez, Elda Castro-Mercado, Idolina Flores-Cortéz, César Arturo Peña-Uribe, Jesús Campos-García, José López-Bucio, Homero Reyes-de la Cruz, Eduardo Valencia-Cantero, Ernesto García-Pineda
Hydrogen peroxide (H2 O2 ) is naturally produced by plant cells during normal development and serves as a messenger that regulates cell metabolism. Despite its importance, the relationship between hydrogen peroxide and the target of rapamycin (TOR) pathway, as well as its impact on cell division, has been poorly analyzed. In this study, we explore the interaction of H2 O2 with TOR, a serine/threonine protein kinase that plays a central role in controlling cell growth, size, and metabolism in Arabidopsis thaliana...
May 28, 2024: Protoplasma
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JOURNAL ARTICLE
Luis Antonio Ochoa-Ramírez, Alberto Kousuke De la Herrán Arita, Jorge Guillermo Sanchez-Zazueta, Efrén Ríos-Burgueño, Joel Murillo-Llanes, Luis Adrián De Jesús-González, Carlos Noe Farfan-Morales, Carlos Daniel Cordero-Rivera, Rosa María Del Ángel, Alejandra Romero-Utrilla, Josué Camberos-Barraza, Marco Antonio Valdez-Flores, Alejandro Camacho-Zamora, José Candelario Batiz-Beltrán, Carla Angulo-Rojo, Alma Marlene Guadrón-Llanos, Verónica Judith Picos-Cárdenas, Claudia Desiree Norzagaray-Valenzuela, Ángel Radamés Rábago-Monzón, Jesús Salvador Velarde-Félix, José Manuel Reyes-Ruiz, Juan Fidel Osuna-Ramos
High-density lipoprotein cholesterol (HDL-c) removes cholesterol, an essential component in lipid rafts, and this cholesterol removal can regulate protein attachment to lipid rafts, modulating their functionality in the immune cell response. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can alter the lipid profile, there is little information on the role of HDL-c and other lipids in prognostic of the coronavirus disease 2019 (COVID-19) in Mexican population. This study aims to evaluate the predictive value of HDL-c and lipid profile on severity and survival of 102 patients infected with SARS-CoV-2 during the COVID-19 first wave...
May 27, 2024: Scientific Reports
#20
JOURNAL ARTICLE
Jorge Tadeu Fim Rosas, José A M Demattê, Nícolas Augusto Rosin, Bruno Dos Anjos Bartsch, Raul Roberto Poppiel, Heidy S Rodriguez-Albarracin, Jean de Jesus Novaes, Paulo Sergio Pavinato, Yuxin Ma, Danilo César de Mello, Marcio Rocha Francelino, Marcelo Alves Rodrigues
Phosphorus (P) is a critical nutrient for primary production in terrestrial and aquatic ecosystems. As P mineral reserves are finite and non-renewable, there is an increasing discussion on its sustainable utilization to safeguard food security for future generations. Understanding the spatial distribution of soil P is central in advancing effective phosphorus management and fostering sustainable agricultural practices. This study aims to digitally map the stocks of available P (AP) and total P (TP) in Brazil at a fine resolution (30 m)...
May 25, 2024: Science of the Total Environment
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