Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Francisco Matos, Fernando Castanheira, Mário Barroso, Mónica Antunes, João Franco, Suzana Fonseca
Pesticides play an important role in forensic toxicology and are usually classified as a single class of chemicals. Despite their commonly perceived unity, pesticides encompass a spectrum of compounds, including organophosphates, carbamates, pyrethroids or organochlorines, among others, each with varying degrees of toxicity. Pesticide analysis in post-mortem samples can be difficult due to the complexity of the samples and to the high toxicity of these compounds. The aim of this study was to develop and validate an easy to use, sensitive, and robust method, using ultra-performance liquid chromatography-tandem mass spectrometry to be incorporated in the routine flow for pesticide analysis in post-mortem blood samples...
April 23, 2024: Journal of Pharmaceutical and Biomedical Analysis
#2
JOURNAL ARTICLE
Luis Perez-de-Llano, Ghislaine Scelo, Trung N Tran, Tham T Le, Malin Faregås, Borja G Cosio, Matthew Peters, Paul E Pfeffer, Mona Al-Ahmad, Riyad O Al-Lehebi, Alan Altraja, Celine Bergeron, Leif H Bjermer, Anne S Bjerrum, Lakmini Bulathsinhala, John Busby, Diana J Cano Rosales, Giorgio W Canonica, Victoria A Carter, Jeremy Charriot, George C Christoff, Eve J Denton, Delbert R Dorscheid, Maria J Fernandez Sanchez, João A Fonseca, Peter G Gibson, Celine Y Y Goh, Liam G Heaney, Enrico Heffler, Mark Hew, Takashi Iwanaga, Rohit Katial, Mariko S Koh, Piotr Kuna, Désirée E S Larenas-Linnemann, Lauri Lehtimäki, Bassam Mahboub, Neil Martin, Hisako Matsumoto, Andrew N Menzies-Gow, Nikolaos G Papadopoulos, Todor A Popov, Celeste M Porsbjerg, Pujan Patel, Chin K Rhee, Mohsen Sadatsafavi, Camille Taillé, Carlos A Torres-Duque, Ming-Ju Tsai, Charlotte S Ulrik, John W Upham, Anna von Bülow, Eileen Wang, Michael E Wechsler, David B Price
RATIONALE: There is no consensus on criteria to include in an asthma remission definition in real-life. Factors associated with achieving remission post-biologic-initiation remain poorly understood. OBJECTIVES: To quantify the proportion of adults with severe asthma achieving multi-domain-defined remission post-biologic-initiation and identify pre-biologic characteristics associated with achieving remission which may be used to predict it. METHODS: This was a longitudinal cohort study using data from 23 countries from the International Severe Asthma Registry...
May 3, 2024: American Journal of Respiratory and Critical Care Medicine
#3
JOURNAL ARTICLE
Elsa De la Cadena, María Fernanda Mojica, Laura J Rojas, Betsy E Castro, Juan Carlos García-Betancur, Steven H Marshall, Natalia Restrepo, Nancy Patricia Castro-Caro, Magalis Fonseca-Carrillo, Christian Pallares, Robert A Bonomo, María Virginia Villegas
UNLABELLED: Resistance to ceftazidime-avibactam (CZA) due to Klebsiella pneumoniae carbapenemase (KPC) variants is increasing worldwide. We characterized two CZA-resistant clinical Klebsiella pneumoniae strains by antimicrobial susceptibility test, conjugation assays, and WGS. Isolates belonged to ST258 and ST45, and produced a KPC-31 and a novel variant KPC-197, respectively. The novel KPC variant presents a deletion of two amino acids on the Ω-loop (del_168-169_EL) and an insertion of two amino acids in position 274 (Ins_274_DS)...
May 3, 2024: Microbiology Spectrum
#4
JOURNAL ARTICLE
Luciana Polaco Covre, Carlos Henrique Fantecelle, Ariadne Mendes Queiroz, Julia Miranda Fardin, Pedro Henrique Miranda, Sian Henson, Alessandra Marcia da Fonseca-Martins, Herbert Leonel de Matos Guedes, David Mosser, Aloisio Falqueto, Arne Akbar, Daniel Claudio Oliveira Gomes
Natural killer (NK) cells include different subsets with diverse effector capacities that are poorly understood in the context of parasitic diseases. Here, we investigated inhibitory and activating receptor expression on NK cells in patients with cutaneous leishmaniasis (CL) and explored their phenotypic and functional heterogeneity based on CD57 and NKG2C expression. The expression of CD57 identified NK cells that accumulated in CL patients and exhibited features of senescence. The CD57+ cells exhibited heightened levels of the activating receptor NKG2C and diminished expression of the inhibitory receptor NKG2A...
May 3, 2024: Clinical and Experimental Immunology
#5
JOURNAL ARTICLE
Oliver Pfaar, Bernardo Sousa-Pinto, Nikolaos G Papadopoulos, Désirée E Larenas-Linnemann, Michal Ordak, Maria J Torres, Ralph Mösges, Ludger Klimek, Torsten Zuberbier, Paolo M Matricardi, Uwe E Berger, Markus Berger, Stephanie Dramburg, Vera Mahler, Sanna K Toppila-Salmi, Karl-Christian Bergmann, Markus Ollert, Salvatore Tripodi, Marek Jutel, Ioana Agache, Ibon Eguiluz-Gracia, G Walter Canonica, Cezmi A Akdis, Milena Sokolowska, Mikhail Sofiev, Mohamed H Shamji, Wienczyslawa Czarlewski, Joao A Fonseca, Anna Bedbrook, Jean Bousquet
In rhinitis and asthma, several mHealth apps have been developed but only a few have been validated. However, these apps have a high potential for improving person-centred care (PCC), especially in allergen immunotherapy (AIT). They can provide support in AIT initiation by selecting the appropriate patient and allergen shared decision-making. They can also help in (i) the evaluation of (early) efficacy, (ii) early and late stopping rules and (iii) the evaluation of (carried-over) efficacy after cessation of the treatment course...
May 3, 2024: Allergy
#6
JOURNAL ARTICLE
Ester Maria Rodrigues de Andrade, Lucas Paixão, Bruno M Mendes, Telma C Ferreira Fonseca
Whole-body counters (WBC) are used in internal dosimetry for in vivo monitoring in radiation protection. The calibration processes of a WBC set-up include the measurement of a physical phantom filled with a certificate radioactive source that usually is referred to a standard set of individuals determined by the International Commission on Radiological Protection (ICRP). The aim of this study was to develop an anthropomorphic and anthropometric female physical phantom for the calibration of the WBC systems...
May 2, 2024: Biomedical Physics & Engineering Express
#7
RANDOMIZED CONTROLLED TRIAL
Yvinna T Rodrigues, Tatiana C L A Silva, Emilė Radytė, Ervinas Bernatavičius, Alexander A Cook, Maria L A S Carvalho, Luiza E S Macedo, Joyce M P Oliveira, Talita D Martins, Maria E Fonseca, Maria T A B C Micussi, Rodrigo Pegado
This study tested the usability of a home-based self-administration transcranial direct current stimulation (tDCS) device designed specifically for women's health needs. This is a single center triple blinded clinical usability study for a new wireless, Bluetooth-controlled wearable tDCS device for women's health. The study aims to evaluate the usability and effective blinding of a home-based tDCS system. A total of forty-nine women of reproductive age were randomly allocated (1:1) to receive one session of active tDCS (n = 24) or sham tDCS (n = 25) over the motor and dorsolateral prefrontal cortex...
2024: PloS One
#8
MULTICENTER STUDY
Andreia Palma, Pedro A Sousa, Carolina Saleiro, Sérgio Barra, Natália António, Luis Adão, João Primo, Ana Lebreiro, Paulo Fonseca, Luís Elvas, Lino Gonçalves
BACKGROUND: Ablation Index (AI) software has allowed better atrial fibrillation (AF) ablation results, but recurrence rates remain significant. Specific serum biomarkers have been associated with this recurrence. OBJECTIVES: To evaluate whether certain biomarkers could be used (either individually or combined) to predict arrhythmia recurrence after AI-guided AF ablation. METHODS: Prospective multicenter observational study of consecutive patients referred for AF ablation from January 2018 to March 2021...
2024: Arquivos Brasileiros de Cardiologia
#9
JOURNAL ARTICLE
M C Lima, K S Dias, G G Fonseca, R S R Leite, M Batistote, M F Paz
Bacterial contamination causes irreparable losses in the performance of alcoholic fermentation. Antibiotics are used to control these microorganisms, but they generate residues and cause microbial resistance. Today the only commercial product used by the mills is hops, but it is very expensive. As an alternative, the objective of this work was to evaluate the feasibility of using extracts from plants grown in the Cerrado for antimicrobial control during an alcoholic fermentation to replace antibiotics. Hydraethanolic extracts of leaves and essential oil of the following species were tested: Schinus terebinthifolius Raddi, Serjania erecta, Serjania marginata, Campomanesia adamantium and Syzygium cumini...
2024: Brazilian Journal of Biology
#10
JOURNAL ARTICLE
Marina Morais, Telma Fonseca, Raquel Machado-Neves, Mrinalini Honavar, Ana Rita Coelho, Joanne Lopes, Emanuel Guerreiro, Silvestre Carneiro
INTRODUCTION: In locally advanced rectal cancers (LARC), tumour node metastasis (TNM) staging is far from optimal. The authors aimed to investigate the value of previously described circulating biomarkers as predictors of prognosis. METHODS: Retrospective analysis of 245 LARC patients diagnosed between January 2010 and December 2022, who underwent neoadjuvant chemoradiotherapy and surgery at two centres. A Cox regression and Kaplan-Meier analysis were performed...
May 2024: Annals of Medicine and Surgery
#11
JOURNAL ARTICLE
Pui Yeng Lam, Fernando Souza-Fonseca-Guimaraes
Natural killer (NK) cells possess potent cytotoxicity against infected and cancerous cells and hold promise in the development of new immunotherapies. This article for the Highlights of 2023 Series focuses on current advances in NK cell biology in cancerous and infectious settings and highlights opportunities for therapeutic interventions, including engineered NK cell therapies and advancements in feeder cell technologies.
May 2, 2024: Immunology and Cell Biology
#12
JOURNAL ARTICLE
Maria Eduarda de Oliveira, Rahisa Scussel, Letícia Alves Borghezan, Paulo Emilio Feuser, Fernanda Fonseca Ramos, Mariana de Melo Cardoso, Ellen De Pieri, Gabriel Paulino Luiz, Nathalia Coral Galvani, Alexandre Gonçalves Dal-Bó, Eduardo Antônio Ferraz Coelho, Ricardo Andrez Machado-de-Ávila
Serodiagnosis methods have been used as platforms for diagnostic tests for many diseases. Due to magnetic nanoparticles' properties to quickly detach from an external magnetic field and particle size effects, these nanomaterials' functionalization allows the specific isolation of target analytes, enhancing accuracy parameters and reducing serodiagnosis time. Superparamagnetic iron oxide nanoparticles (MNPs) were synthesized and functionalized with polyethylene glycol (PEG) and then associated with the synthetic Leishmaniosis epitope...
April 26, 2024: Diagnostic Microbiology and Infectious Disease
#13
JOURNAL ARTICLE
Bianca Moreira de Souza, Salene Angelini Colombo, Roberta do Carmo Teixeira, Isadora Martins Pinto Coelho, Werik Dos Santos Barrado, Breno Oliveira Lima Ramos, Érica Lorenza Martins Araujo, Gustavo Canesso Bicalho, Maria Isabel de Azevedo, Kelly Moura Keller, Fabiana Dos Santos Monti, Lorena Diniz Macedo Silva Maia, Danielle Ferreira de Magalhães Soares, Camila Stefanie Fonseca de Oliveira
Sporotrichosis is a widespread fungal infection that affects skin and subcutaneous tissues in humans and animals. In cats, it is displayed as nodules, ulcers and lesions on the nasal and respiratory mucosa. Antifungal treatment of cats is crucial but many cases are difficult, thus resulting in discontinue of the treatment, with disastrous consequences for the animal, encouraging contamination of the environment, other animals and people. The effects of responsible ownership education and health education for owners of cats with feline sporotrichosis as well as the interval between veterinary consultations on treatment outcomes for three groups of owners and their pet cats were evaluated in this study...
April 20, 2024: Preventive Veterinary Medicine
#14
JOURNAL ARTICLE
Luciano Bernardes Leite, Leôncio Lopes Soares, Alexandre Martins Oliveira Portes, Thayana Inácia Soares, Bruna Aparecida Fonseca da Silva, Taís Rodrigues Dias, Sebastião Felipe Ferreira Costa, Luiz Otávio Guimarães-Ervilha, Mirian Quintão Assis, Victor Neiva Lavorato, Albená Nunes da Silva, Mariana Machado-Neves, Emily Correna Carlo Reis, Antônio José Natali
BACKGROUND: Under the adverse remodeling of the right ventricle and interventricular septum in pulmonary arterial hypertension (PAH) the left ventricle (LV) dynamics is impaired. Despite the benefits of combined aerobic and resistance physical trainings to individuals with PAH, its impact on the LV is not fully understood. OBJECTIVE: To test whether moderate-intensity combined physical training performed during the development of PAH induced by MCT in rats is beneficial to the LV's structure and function...
May 1, 2024: Clinical Hypertension
#15
JOURNAL ARTICLE
Javier Oscar Dagnesses Fonseca, Juan Emmanuel Danes Grases, Paloma Luengo Batres, Pablo Calvo Espino
A jejunal diverticular haemorrhage is the second most common complication of jejunum diverticula. It can manifest clinically as acute upper gastrointestinal bleeding and is common to imitate acute rectal bleeding. Bleeding is usually associated with or without haemodynamic stability. Its diagnosis is challenging, requiring imaging examinations. Treatment is conservative management or surgery.
April 30, 2024: BMJ Case Reports
#16
JOURNAL ARTICLE
Carlos Eduardo Santos, Luis Felipe da Fonseca Reis, Sidney Fernandes da Silva, Iasmim Maria Pereira Pinto Fonseca, Wellington de Oliveira Pereira, Laura Franco Pessoa, Paolo Blanco Villela, Agnaldo José Lopes
This study aimed to evaluate the presence of dynamic hyperinflation (DH) during the Glittre-ADL test (TGlittre) coupled to the dynamic ventilation measurements in people with central obesity (pwCO) and to correlate it with lung mechanics at rest. Sixty-four pwCO underwent TGlittre and the following resting lung function tests: spirometry and impulse oscillometry system (IOS). On TGlittre, 22 participants presented DH at the end of the test (DH group), while 42 did not present DH (NDH group). Body mass index (BMI), waist circumference (WC), and hip circumference (HC) were higher in the DH group than in the NDH group...
April 28, 2024: Respiratory Physiology & Neurobiology
#17
JOURNAL ARTICLE
Diogo V Fonsêca, Pablo R da Silva, Hugo F O Pires, Juliana S Rocha, Leandra Eugênia G de Oliveira, Flavia M S Reis, Erika B M Cavalho, Natalia D N Pazos, Natália F de Sousa, Erika C Guedes, Leandro R Ribeiro, Rita de Cassia S Sá, Mirian G S S Salvadori, Damião P Sousa, Marcus T Scotti, Cicero F B Felipe, Reinaldo N de Almeida, Luciana Scotti
Tetrahydrolinalool (THL) is an acyclic monoterpene alcohol, produced during linalol metabolism and also a constituent of essential oils. As described in the literature, many monoterpenes present anticonvulsant properties, and thus we became interested in evaluating the anticonvulsant activity of Tetrahydrolinalool using in mice model as well as in silico approaches. Our results demonstrated that THL increased latency to seizure onset and also reduced the mortality, in picrotoxin induced seizure tests. The results may be related to GABAergic regulation, which was also suggested in seizure testing induced by 3-mercapto-propionic acid...
April 30, 2024: ChemMedChem
#18
JOURNAL ARTICLE
Diéssy Kipper, Silvia De Carli, Nathalie de Souza Zanetti, Andrea Karoline Mascitti, André Salvador Kazantzi Fonseca, Nilo Ikuta, Vagner Ricardo Lunge
Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum ( S. Pullorum) is a pathogenic bacterium that causes Pullorum disease (PD). PD is an acute systemic disease that affects young chickens, causing white diarrhea and high mortality. Although many sanitary programs have been carried out to eradicate S. Pullorum, PD outbreaks have been reported in different types of birds (layers, broilers, breeders) worldwide. This study aimed to evaluate the evolution and genetic characteristics of S. Pullorum isolated from PD in Brazil...
March 2024: Avian Diseases
#19
JOURNAL ARTICLE
José Alcides Almeida de Arruda, Mariana Villarroel-Dorrego, Clara Herrera Freire, Ignacio Molina-Ávila, Juan Martin Pimentel-Solá, Gerardo Gilligan, Eduardo Piemonte, René Panico, Juan Cruz Romero Panico, Saray Aranda-Romo, Francisco Javier Tejeda-Nava, Mônica Simões Israel, John Lennon Silva Cunha, Vanessa Alves de Medeiros, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Israel Leal Cavalcante, José Victor Lemos Ventura, Fernanda Silva de Lima, Victor Zanetti Drumond, Lucas Guimarães Abreu, Tarcília Aparecida Silva, Felipe Paiva Fonseca, Ricardo Alves Mesquita, René Martínez-Flores, Karina Cordero-Torres, Richard Ahumada-Ossandón, Jorge Guzmán, Raiza Toro, José Cândido Caldeira Xavier-Júnior, Sebastião Silvério Sousa-Neto, Diego Antônio Costa Arantes, Elismauro Francisco Mendonça, Victor de Mello Palma, Márcia Gaiger de Oliveira, Fernanda Visioli, Karem L Ortega, Jefferson R Tenório, Bruno Augusto Benevenuto de Andrade
BACKGROUND: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that may affect the oral mucosa. The variable spectrum of oral lesions observed in SLE can pose challenges in diagnosis, particularly when the lesions occur in isolation. The aim of this study was to describe the oral lesions occurring in patients with SLE from Latin America. METHODS: This collaborative record-based study involving 11 oral and maxillofacial pathology and medicine services across Venezuela, Argentina, Chile, Brazil, and Mexico describes the clinicopathological profile of SLE-related oral lesions...
April 30, 2024: Lupus
#20
JOURNAL ARTICLE
João Inácio Gomes Vieira, Larissa Graciano Braga, Tatiane C S Chud, Pablo Henrique Ferreira, Simone Eliza Facioni Guimarães, Marta Fonseca Martins, João Cláudio do Carmo Panetto, Marco Antonio Machado, Danielly Beraldo Dos Santos Silva, Cristina Moreira Bonafé, Ana Fabrícia Braga Magalhães, Marcos Vinícius G B da Silva, Lucas Lima Verardo
The beef cattle industry has experienced a shift driven by a market demand for healthier meat, cost efficiency and environmental sustainability in recent years. Consequently, there has been a growing focus on the fatty acids content and functions of meat in cattle breeding programmes. Besides, a deeper understanding of the biological mechanisms influencing the expression of different phenotypes related to fatty acid profiles is crucial. In this study, we aimed to identify Single-Nucleotide Variants (SNV) and Insertion/Deletion (InDels) DNA variants in candidate genes related to fatty acid profiles described in genomic, transcriptomic and proteomic studies conducted in beef cattle breeds...
April 30, 2024: Journal of Animal Breeding and Genetics
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
