Nao Muraki, Nozomi Kawabe, Ayano Ohashi, Kanna Umeda, Masahito Katsuda, Aya Tomatsu, Mikina Yoshida, Kazuki Komeda, John D Minna, Ichidai Tanaka, Masahiro Morise, Miyoko Matsushima, Yusuke Matsui, Tsutomu Kawabe, Mitsuo Sato
Certain oncogenes, including mutant RAS and BRAF, induce a type of senescence known as oncogene-induced senescence (OIS) in normal cells in a cell-type-specific manner. OIS serves as a barrier to transformation by activated oncogenes. Our previous studies showed that mutant KRASV12 did not efficiently induce OIS in an hTERT / Cdk4-immortalized normal human bronchial epithelial cell line (HBEC3), but it did enhance both anchorage-dependent and anchorage-independent growth. In this study, we investigated whether mutant BRAF, a well-known inducer of OIS, could trigger OIS in HBEC3 cells...
April 26, 2024: Experimental Cell Research