Xuqi Sun, Xiao Teng, Chuan Liu, Weihong Tian, Jinlin Cheng, Shuqiang Hao, Yuzhi Jin, Libing Hong, Yongqiang Zheng, Xiaomeng Dai, Linying Wu, Lulu Liu, Xiaodong Teng, Yi Shi, Peng Zhao, Weijia Fang, Yu Shi, Xuanwen Bao
Heterogeneous organ-specific responses to immunotherapy exist in lung cancer. Dissecting tumor microenvironment (TME) can provide new insights into the mechanisms of divergent responses, the process of which remains poor, partly due to the challenges associated with single-cell profiling using formalin-fixed paraffin-embedded (FFPE) materials. In this study, single-cell nuclei RNA sequencing and imaging mass cytometry (IMC) are used to dissect organ-specific cellular and spatial TME based on FFPE samples from paired primary lung adenocarcinoma (LUAD) and metastases...
April 29, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)