Sailing

BACKGROUND: Sleep and physical performance are strongly related and mutually influence each other. Athletes, particularly in disciplines like offshore sailing and ultra-endurance sports, often suffer from sleep deprivation due to factors like irregular training times, travel, and the extended duration of events like 100-mile mountain races. Despite growing interest in sleep's role in sports science, few studies have specifically investigated the sleep patterns of ultramarathon runners...

Coronavirus disease 2019 (COVID-19) is a severe and infectious respiratory condition caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This case-control study aimed to evaluate serum levels of various immunological markers in patients with COVID-19 compared to those with bacterial pneumonia and a healthy control group. Serum samples were collected from adult participants across various COVID-19 isolation centers, including Kassala State and Ahmed Gasim Hospital, between April and June 2021...

An aberration-free line scanning confocal Raman imager (named AFLSCRI) is developed to achieve rapid Raman imaging. As an application example, various types and sizes of MPs are identified through Raman imaging combined with a machine learning algorithm. The system has excellent performance with a spatial resolution of 2 µm and spectral resolution of 4 cm-1 . Compared to traditional point-scanning Raman imaging systems, the detection speed is improved by 2 orders of magnitude. The pervasive nature of MPs results in their infiltration into the food chain, raising concerns for human health due to the potential for chemical leaching and the introduction of persistent organic pollutants...

The synthesis of new surfactants helps to mitigate the environmental and financial effects of oil spills by providing efficient cleanup options. Herein, this study provides the development of a binary mixture of Span 80 and Choline myristate [Cho][Mys], a surface-active ionic liquid (SAIL) as green dispersant for oil spill remediation. The synergistic interaction at a 60:40 (w/w) ratio significantly lowered the critical micelle concentration (cmc) to 0.029 mM. Dispersion efficiency tests with Arab crude oil showed optimal performance at a 60:40 ratio of Span 80 and [Cho][Mys] (1:25 dispersant to oil ratio, v/v), achieving 81...

Improving the spectrum efficiency (SE) is an effective method to further enhance the data rate of bandwidth-limited underwater wireless optical communication (UWOC) systems. Non-orthogonal frequency-division multiplexing (NOFDM) with a compression factor of 0.5 can save half of the bandwidth without introducing any inter-carrier-interference (ICI) only if the total number of subcarriers is large enough, and we termed it as half-spectrum OFDM (HS-OFDM). To the best of our knowledge, this is the first reported work on a closed-form HS-OFDM signal in the discrete domain from the perspective of a correlation matrix...

Multimodal neuroimaging grants a powerful in vivo window into the structure and function of the human brain. Recent methodological and conceptual advances have enabled investigations of the interplay between large-scale spatial trends - or gradients - in brain structure and function, offering a framework to unify principles of brain organization across multiple scales. Strong community enthusiasm for these techniques has been instrumental in their widespread adoption and implementation to answer key questions in neuroscience...

International sailing regattas are major sporting events often held within coastal marine environments which overlap with the habitats of marine species. Although races are confined to courses, the popularity of these events can attract large spectator flotillas, sometimes composed of hundreds of motorized vessels. Underwater noise from these flotillas can potentially alter soundscapes experienced by marine species. To understand how these flotillas may alter soundscapes, acoustic recordings were taken around racecourses during the 36th America's Cup in the Hauraki Gulf, New Zealand in 2021...

INTRODUCTION: Lettuce production and quality could be seriously affected by the increasingly limited water resources. METHODS: The effect of drought on the content of two antioxidant compounds, vitamin C and anthocyanins, in five cultivated lettuces and two wild relatives was assessed for 2 years. RESULTS AND DISCUSION: In leaf samples, Lactuca wild species generally had a higher content of total vitamin C than the cultivated lettuces. In contrast, the commercial varieties usually contained more total anthocyanins than the wild species...

INTRODUCTION: this study aimed to investigate the prevalence and management of food allergies (FA) and drug allergies (DA) in Morocco. Sparse and conflicting epidemiological data exist on the exact prevalence of allergies in the country. The rise in allergies can be attributed to various factors. METHODS: the study analyzed data from patients with suspected FA and DA who sought medical attention. Statistical tests were used to analyze the data, percentages were computed for qualitative variables, and for quantitative variables, medians or means accompanied by standard deviations (SD) were calculated...

Doping active agents into metal-organic frameworks (MOFs) is widely sought after owing to its potential to enhance adsorption and photocatalytic efficiency, surpassing the potential of bare frameworks. This study incorporated a catalytically active NS-ligand (1,2-benzisothiazolin-3-one) into a very stable and porous PCN-600 MOF via an in situ synthesis approach. The NS-ligand, which matched with the host ligands of PCN-600, enabled the highly efficient synthesis of NS-co-doped MOFs. The pristine PCN-600 framework and morphology were retained in the MOF altered with the NS-ligand, as demonstrated by XRD, FTIR, and SEM characterizations...

China leads the world in freshwater pearl production, an industry in which the triangle sail mussel ( Sinohyriopsis cumingii ) plays a pivotal role. In this paper, we report a high-quality chromosome-level genome assembly of S. cumingii with a size of 2.90 Gb-the largest yet reported among bivalves-and 89.92% anchorage onto 19 linkage groups. The assembled genome has 37,696 protein-coding genes and 50.86% repeat elements. A comparative genomic analysis revealed expansions of 752 gene families, mostly associated with biomineralization, and 237 genes under strong positive selection...

Formaldehyde (HCHO) is considered one of the most abundant gas-phase carbonyl compounds in the atmosphere, which can be directly emitted through transportation sources. Long-Path Differential Optical Absorption Spectroscopy (LP-DOAS) was used to observe HCHO in the river channel of Wusong Wharf in Shanghai, China for the whole year of 2019. Due to the impact of ship activity, the annual average HCHO level in the channel is about 2.5 times higher than that in the nearby campus environment. To explain the sources of HCHO under different meteorological conditions, the tracer-pair of CO and Ox (NO2 +O3 ) was used on the clustered air masses...

While motor and psychiatric phenotypes in idiopathic dystonia are increasingly well understood, a few studies have examined the rate, type, and temporal pattern of other clinical co-morbidities in dystonia. Here, we determine the rates of clinical diagnoses across 13 broad systems-based diagnostic groups, comparing an overall idiopathic dystonia cohort, and sub-cohorts of cervical dystonia, blepharospasm, and dystonic tremor, to a matched-control cohort. Using the SAIL databank, we undertook a longitudinal population-based cohort study (January 1st 1994-December 31st 2017) using anonymised electronic healthcare records for individuals living in Wales (UK), identifying those diagnosed with dystonia through use of a previously validated algorithm...

The objective of this study was to examine the effect of 11 organochlorine pesticides on human and rat 17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) in human placental and rat ovarian microsome and on estradiol production in BeWo cells. The results showed that the IC50 values for endosulfan, fenhexamid, chlordecone, and rhothane on human 17β-HSD1 were 21.37, 73.25, 92.80, and 117.69μM. Kinetic analysis revealed that endosulfan acts as a competitive inhibitor, fenhexamid as a mixed/competitive inhibitor, chlordecone and rhothane as a mixed/uncompetitive inhibitor...

BACKGROUND: Dual-energy computed tomography (DE-CT) can differentiate between hemorrhage and iodine contrast medium leakage following mechanical thrombectomy (MT) for acute ischemic stroke (AIS). We determined whether subarachnoid hemorrhage (SAH) and subarachnoid iodine leakage (SAIL) on DE-CT following MT were associated with malignant brain edema (MBE). METHODS: We analyzed the medical records of 81 consecutive anterior circulation AIS patients who underwent MT...

COVID-19 has had a serious impact on the development of the global shipping industry, especially since the impact on the cruise tourism industry was unprecedented. This study took cruise ships sailing in China ECA, China Exclusive Economic Zone (EEZ), Yangtze River main line, and Xijiang River main line Chinese waters as an example to analyze the key changes in cruise ship emissions during the pandemic. Automatic identification system (AIS) data, vessel static data, and emission control regional data are used to conduct a comprehensive analysis of cruise ship emissions from multiple perspectives such as a port-to-regional comparison...

BACKGROUND: Most patients with chronic lymphocytic leukaemia progress after treatment or retreatment with targeted therapy or chemoimmunotherapy and have limited subsequent treatment options. Response levels to the single-agent venetoclax in the relapsed setting is unknown. We aimed to assess venetoclax activity in patients with or without previous B-cell receptor-associated kinase inhibitor (BCRi) treatment. METHODS: This multicentre, open-label, single-arm, phase 3b trial (VENICE-1) assessed activity and safety of venetoclax monotherapy in adults with relapsed or refractory chronic lymphocytic leukaemia, stratified by previous exposure to a BCRi...

Underwater noise pollution is a significant environmental issue that can have detrimental effects on marine ecosystems. One of the main sources of underwater noise pollution is ship traffic, which has been shown to negatively impact marine animals by masking communication signals and altering their behaviors. This study represents the first comprehensive analysis of underwater ship noise in the Red Sea, wherein noise maps of ships sailing through the main shipping lane in the Red Sea were simulated by integrating both anthropogenic and environmental variables...

Global health crises such as the recent coronavirus disease 2019 (COVID-19) pandemic have highlighted the unique value of scientific research in the realm of public health and related disciplines. Although we have witnessed rapid growth in scientific output in the past years, concerns regarding scientific rigor and research integrity also emerged.

OBJECTIVE: People with epilepsy (PWE) may be at an increased risk of severe COVID-19. It is important to characterize this risk to inform PWE and for future health and care planning. We assessed whether PWE were at higher risk of being hospitalized with, or dying from, COVID-19. METHODS: We performed a retrospective cohort study using linked, population-scale, anonymized electronic health records from the SAIL (Secure Anonymised Information Linkage) databank. This includes hospital admission and demographic data for the complete Welsh population (3...