Sailing

Tuberculosis continues to remain a major public health challenge, especially in low- and middle-income countries. Unilateral vocal cord palsy in adults as the sole manifestation of tubercular mediastinal lymphadenopathy has been rarely reported. A 22-year-old lady presented with a history of hoarseness of voice for the past month. The general physical examination revealed palpable lymph nodes in the left axilla. Axial CT sections at the level of the vocal cords demonstrated dilation of the right laryngeal ventricle and mild anteromedial deviation of the ipsilateral arytenoid cartilage ("sail" sign) suggestive of a right vocal cord palsy...

In ancient Greek mythology, sirens were creatures of stunning beauty whose mystical songs led sailors to sail their boats onto hidden rocks and into total destruction. In this issue, Mason-Osann and colleagues present data in the context of acute myelogenous leukemia to suggest that while synergy may show initial attractions in drug combinations, it may carry with it hazards previously unforeseen. See related article by Mason-Osann et al. (1).

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BACKGROUND: Eosinophilic esophagitis (EoE) is an increasingly common inflammatory condition of the esophagus; however, the underlying immunologic mechanisms remain poorly understood. The epithelium-derived cytokine IL-33 is associated with type 2 immune responses and elevated in esophageal biopsies from EoE subjects. OBJECTIVE: We hypothesized that overexpression of IL-33 by the esophageal epithelium would promote the immunopathology of EoE. METHODS: We evaluated the functional consequences of esophageal epithelial overexpression of a secreted and active form of IL-33 (saIL-33) in a novel transgenic mouse, EoE33...

INTRODUCTION: Research finds that experiencing psychological stress can be associated with engaging in less physical activity, a critical contributor to operational readiness and overall health and well-being. As navy personnel tend to engage in lower levels of physical activity than other military personnel, the purpose of this study was to examine the relationship between stress and physical activity in the Royal Canadian Navy (RCN) and identify moderators of this relationship. MATERIALS AND METHODS: Data for this study were obtained from an electronic workplace well-being survey administered to a stratified random sample of 930 members in hard sea occupations managed by the RCN...

The radiation pressure force and torque on a one-dimensional bi-grating composed of a Si-SiO2 high contrast binary metagrating is analyzed for the purpose of stable beam riding whereupon a high power laser having an expanding Gaussian irradiance distribution propels the grating in outer space, free from gravitational forces. The binary metagrating structure has been simultaneously optimized to afford high forward thrust, and corrective restoring forces and torques in the event of small linear and angular disturbances...

Two dielectric relaxations located at approximately 10 and 300 MHz were analyzed in the microemulsion composed of the polar ionic liquid (PIL) 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4 ]), the surface-active ionic liquid (SAIL) 1-butyl-3-methylimidazolium 1,4-bis(2-ethylhexyl) sulfosuccinate ([bmim][AOT]), and benzene. The curve of the dc conductivity vs PIL weight fraction shows two inflection points, namely, 16.69 and 27.90 wt %, which are used to divide the PIL/O, bicontinuous (B.C.), and O/PIL subregions...

The present work provides new evidence of the ongoing potential of surface-active ionic liquids (SAILs) and surface-active quaternary ammonium salts (surface-active QASs). To achieve this, a series of compounds were synthesized with a yield of ≥85%, and their thermal analyses were studied. Additionally, antimicrobial activity against both human pathogenic and soil microorganisms was investigated. Subsequently, their surface properties were explored with the aim of utilizing SAILs and surface-active QASs as alternatives to commercial amphiphilic compounds...

The aim of this study was to analyse the variables that determine the performance of the Optimist class during a regatta in different wind conditions. A total of 203 elite sailors of the Optimist class (121 boys and 82 girls) participated in the study. According to their ranking in the regatta, the sample was divided into four performance groups. In a regatta with 11 races, the velocity made good (VMG), the distance and the manoeuvres were evaluated by means of GNSS equipment in three different courses. The boys performed a greater number of upwind and running manoeuvres than the girls...

The history of science is increasingly directing its attention to the diachronic examination of women's involvement within spaces dedicated to scientific inquiry. While this field of study boasts rich and meticulous historiography, delving into the sixteenth century leaves the impression of encountering either a noticeable absence of women in the realm of natural history or an underexplored period in this regard. Undoubtedly, within the Italian context of the time, the cultural milieu shaped by the Counter-Reformation further heightened the social challenges faced by women...

Exposure to cigarette smoke (CS) adversely affects ovarian health and it is currently unknown how CS exposure causes ovarian injury. This study compared the differences in proteomics between CS exposure and healthy control groups using liquid chromatography-tandem mass spectrometry quantitative proteomics to further understand the molecular mechanism of ovarian cell injury in mice exposed to CS. Furthermore, western blotting and qPCR were carried out to validate the proteomic analysis outcomes. CREB1 was selected from the differentially expressed proteins, and then the down-regulation of CREB1 and phosphorylated CREB1(Ser133) expressions were confirmed in mice ovarian tissue and human ovarian granulosa cells (KGN cells) after CS exposure...

PURPOSE: Using Wales's national dataset for maternity and births as a core dataset, we have linked related datasets to create a more complete and comprehensive entire country birth cohort. Data of anonymised identified persons are linked on the individual level to data from health, social care and education data within the Secure Anonymised Information Linkage (SAIL) Databank. Each individual is assigned an encrypted Anonymised Linking Field; this field is used to link anonymised individuals across datasets...

The spatial-temporal distribution, source, and potential ecological risk of polycyclic aromatic hydrocarbons (PAHs) in surface seawater from Laizhou Bay were investigated. The total PAH (ΣPAH) concentrations ranged from 277 to 4393 ng/L with an average of 1178 ng/L, thereby suggesting a relatively moderate to high PAH exposure level in Laizhou Bay in comparison to other bays in the world. The composition patterns and source apportionment results revealed that the coal, biomass burning, diesel emissions, and petroleum combustion as well as the combination of these processes were the dominant sources of PAHs in the surface water, which were closely associated with sail process and sewage effluents...

Detecting proteins in ultralow concentrations in complex media is important for many applications but often relies on complicated techniques. Herein, a single-molecule protein analyzer with the potential for high-throughput applications is reported. Gold-coated magnetic nanoparticles with DNA-labeled antibodies were used for target recognition and separation. The immunocomplex was loaded into microdroplets generated with centrifugation. Immuno-PCR amplification of the DNA enabled the quantification of proteins at the level of single molecules...

Artificial intelligence (AI) has the potential to improve life and reduce risks by providing large amounts of information embedded in big databases and by suggesting or implementing automated decisions under uncertainties. Yet, in the design of a prescriptive AI algorithm, some problems may occur, first and clearly, if the AI information is wrong or incomplete. But the main point of this article is that under uncertainties, the decision algorithm, rational or not, includes, in one way or another, a risk attitude in addition to deterministic preferences...

OBJECTIVE: To investigate the longevity of a large sample of Olympic Games participants, considering the interaction between different types of sports and medal awards. METHODOLGY: Data scraping from Wikipedia and Wikidata allowed us to collect a sample of 102,993 famous athletes. We selected 20 of the most populated disciplines to make the groups comparable. We conducted a comparison of life duration on a subset of 17,194 elite athletes, predominantly male, dead at the time of analysis...

STUDY QUESTION: What is the effect of small follicles on clinical pregnancy and multiple pregnancy rates in women undergoing IUI with ovarian stimulation (IUI-OS)? SUMMARY ANSWER: The presence of ≥2 small follicles with a diameter of 10-12 or 12-14 mm was associated with an increased chance of clinical pregnancy and the presence of any 12-14 mm or larger follicles, but not smaller follicles, was statistically significantly associated with an increased risk for multiple pregnancy...

BACKGROUND: Predicting breast cancer molecular subtypes can help guide individualised clinical treatment of patients who need the rational preoperative treatment. This study aimed to investigate the efficacy of preoperative prediction of breast cancer molecular subtypes by contrast-enhanced mammography (CEM) radiomic features. METHODS: This retrospective two-centre study included women with breast cancer who underwent CEM preoperatively between August 2016 and May 2022...

Bisphenol A (BPA) is a widely used plastic material, but its potential endocrine disrupting effect has restricted its use. The BPA alternatives have raised concerns. This study aimed to compare inhibitory potencies of 11 BPA analogues on human and rat placental aromatase (CYP19A1). The inhibitory potency on human CYP19A1 ranged from bisphenol H (IC50 , 0.93 μM) to tetramethyl BPA and tetrabromobisphenol S (ineffective at 100 μM) when compared to BPA (IC50 , 73.48 μM). Most of them were mixed/competitive inhibitors and inhibited estradiol production in human BeWo cells...

Melioidosis, caused by Burkholderia pseudomallei , is a rare but potentially fatal bacterial disease endemic to tropical and subtropical regions worldwide. It is typically acquired through contact with contaminated soil or fresh water. Before this investigation, B. pseudomallei was not known to have been isolated from the environment in the continental United States. Here, we report on three patients living in the same Mississippi Gulf Coast county who presented with melioidosis within a 3-year period. They were infected by the same Western Hemisphere B...