keyword
https://read.qxmd.com/read/38691776/characteristics-of-brain-lesions-found-using-mri-imaging-in-patients-with-post-covid-with-signs-of-cognitive-decline
#1
JOURNAL ARTICLE
Artur V Kurakh, Vladyslava I Ahii, Ivan V Chopey, Mykhailo M Hechko, Kseniya I Chubirko
OBJECTIVE: Aim: To describe and evaluate abnormalities of the brain in post-COVID patients with neurologic symptoms and cognitive deficits using MRI imaging of the brain. PATIENTS AND METHODS: Materials and Methods: We included 21 patients with a previous positive PCR testing for SARS-CoV-2 and one or more of the following symptoms: memory and cognitive decline, dizziness, anxiety, depression, chronic headaches. All patients had MRI imaging done at onset of symptoms, but after at least 1 year after positive testing for COVID-19 based on the patient's previous medical history...
2024: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38691622/early-skeletal-outcomes-after-hematopoietic-stem-and-progenitor-cell-gene-therapy-for-hurler-syndrome
#2
JOURNAL ARTICLE
Giulia Consiglieri, Francesca Tucci, Maurizio De Pellegrin, Barbara Guerrini, Alessandro Cattoni, Giulia Risca, Stefano Scarparo, Marina Sarzana, Silvia Pontesilli, Renata Mellone, Serena Gasperini, Stefania Galimberti, Paolo Silvani, Chiara Filisetti, Silvia Darin, Giulia Forni, Simona Miglietta, Ludovica Santi, Marcella Facchini, Ambra Corti, Francesca Fumagalli, Maria Pia Cicalese, Valeria Calbi, Maddalena Migliavacca, Federica Barzaghi, Francesca Ferrua, Vera Gallo, Salvatore Recupero, Daniele Canarutto, Matteo Doglio, Lucia Tedesco, Nicola Volpi, Attilio Rovelli, Giancarlo la Marca, Maria Grazia Valsecchi, Stefano Zancan, Fabio Ciceri, Luigi Naldini, Cristina Baldoli, Rossella Parini, Bernhard Gentner, Alessandro Aiuti, Maria Ester Bernardo
Mucopolysaccharidosis type I Hurler (MPSIH) is characterized by severe and progressive skeletal dysplasia that is not fully addressed by allogeneic hematopoietic stem cell transplantation (HSCT). Autologous hematopoietic stem progenitor cell-gene therapy (HSPC-GT) provides superior metabolic correction in patients with MPSIH compared with HSCT; however, its ability to affect skeletal manifestations is unknown. Eight patients with MPSIH (mean age at treatment: 1.9 years) received lentiviral-based HSPC-GT in a phase 1/2 clinical trial (NCT03488394)...
May 2024: Science Translational Medicine
https://read.qxmd.com/read/38691619/multimodal-mri-reveals-brainstem-connections-that-sustain-wakefulness-in-human-consciousness
#3
JOURNAL ARTICLE
Brian L Edlow, Mark Olchanyi, Holly J Freeman, Jian Li, Chiara Maffei, Samuel B Snider, Lilla Zöllei, J Eugenio Iglesias, Jean Augustinack, Yelena G Bodien, Robin L Haynes, Douglas N Greve, Bram R Diamond, Allison Stevens, Joseph T Giacino, Christophe Destrieux, Andre van der Kouwe, Emery N Brown, Rebecca D Folkerth, Bruce Fischl, Hannah C Kinney
Consciousness is composed of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that underlie awareness in the human brain, but knowledge about the subcortical networks that sustain arousal in humans is incomplete. Here, we aimed to map the connectivity of a proposed subcortical arousal network that sustains wakefulness in the human brain, analogous to the cortical default mode network (DMN) that has been shown to contribute to awareness. We integrated data from ex vivo diffusion magnetic resonance imaging (MRI) of three human brains, obtained at autopsy from neurologically normal individuals, with immunohistochemical staining of subcortical brain sections...
May 2024: Science Translational Medicine
https://read.qxmd.com/read/38691411/deep-learning-models-for-abdominal-ct-organ-segmentation-in-children-development-and-validation-in-internal-and-heterogeneous-public-datasets
#4
JOURNAL ARTICLE
Elanchezhian Somasundaram, Zachary Taylor, Vinicius V Alves, Lisa Qiu, Benjamin Fortson, Neeraja Mahalingam, Jonathan Dudley, Hailong Li, Samuel L Brady, Andrew T Trout, Jonathan R Dillman
Background: Deep-learning abdominal organ segmentation algorithms have shown excellent results in adults; validation in children is sparse. Objective: To develop and validate deep-learning models for liver, spleen, and pancreas segmentation on pediatric CT examinations. Methods: This retrospective study developed and validated deep-learning models for liver, spleen, and pancreas segmentation using 1731 CT examinations (1504 training, 221 testing), derived from three internal institutional pediatric (age ≤18) datasets (n=483) and three public datasets comprising pediatric and adult examinations with various pathologies (n=1248)...
May 1, 2024: AJR. American Journal of Roentgenology
https://read.qxmd.com/read/38691404/integrating-text-and-image-analysis-exploring-gpt-4v-s-capabilities-in-advanced-radiological-applications-across-subspecialties
#5
JOURNAL ARTICLE
Felix Busch, Tianyu Han, Marcus R Makowski, Daniel Truhn, Keno K Bressem, Lisa Adams
This study demonstrates that GPT-4V outperforms GPT-4 across radiology subspecialties in analyzing 207 cases with 1312 images from the Radiological Society of North America Case Collection.
May 1, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38691356/safety-and-tolerability-of-online-adaptive-high-field-magnetic-resonance-guided-radiotherapy
#6
JOURNAL ARTICLE
Jasmijn M Westerhoff, Lois A Daamen, John P Christodouleas, Erwin L A Blezer, Ananya Choudhury, Rosalyne L Westley, Beth A Erickson, Clifton D Fuller, Shaista Hafeez, Uulke A van der Heide, Martijn P W Intven, Anna M Kirby, Susan Lalondrelle, Bruce D Minsky, Stella Mook, Marlies E Nowee, Corrie A M Marijnen, Kristina M Orrling, Arjun Sahgal, Christopher J Schultz, Corinne Faivre-Finn, Robbert J H A Tersteeg, Alison C Tree, Chia-Lin Tseng, Tine Schytte, Dustin M Silk, Dave Eggert, Marco Luzzara, Jochem R N van der Voort van Zyp, Helena M Verkooijen, William A Hall
IMPORTANCE: In 2018, the first online adaptive magnetic resonance (MR)-guided radiotherapy (MRgRT) system using a 1.5-T MR-equipped linear accelerator (1.5-T MR-Linac) was clinically introduced. This system enables online adaptive radiotherapy, in which the radiation plan is adapted to size and shape changes of targets at each treatment session based on daily MR-visualized anatomy. OBJECTIVE: To evaluate safety, tolerability, and technical feasibility of treatment with a 1...
May 1, 2024: JAMA Network Open
https://read.qxmd.com/read/38691234/parotid-gland-segmentation-using-purely-transformer-based-u-shaped-network-and-multimodal-mri
#7
JOURNAL ARTICLE
Zi'an Xu, Yin Dai, Fayu Liu, Siqi Li, Sheng Liu, Lifu Shi, Jun Fu
Parotid gland tumors account for approximately 2% to 10% of head and neck tumors. Segmentation of parotid glands and tumors on magnetic resonance images is essential in accurately diagnosing and selecting appropriate surgical plans. However, segmentation of parotid glands is particularly challenging due to their variable shape and low contrast with surrounding structures. Recently, deep learning has developed rapidly, and Transformer-based networks have performed well on many computer vision tasks. However, Transformer-based networks have yet to be well used in parotid gland segmentation tasks...
May 1, 2024: Annals of Biomedical Engineering
https://read.qxmd.com/read/38691232/data-driven-gating-ddg-based-motion-match-for-improved-ctac-registration
#8
JOURNAL ARTICLE
Ella L Cook, Kuan-Hao Su, Geoff S Higgins, Robert Johnsen, Jean-Paul Bouhnik, Daniel R McGowan
BACKGROUND: Respiratory motion artefacts are a pitfall in thoracic PET/CT imaging. A source of these motion artefacts within PET images is the CT used for attenuation correction of the images. The arbitrary respiratory phase in which the helical CT ( <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:msub><mml:mtext>CT</mml:mtext> <mml:mtext>helical</mml:mtext></mml:msub> </mml:math> ) is acquired often causes misregistration between PET and CT images, leading to inaccurate attenuation correction of the PET image...
May 1, 2024: EJNMMI Physics
https://read.qxmd.com/read/38691177/using-photogrammetry-to-analyze-anatomical-changes-in-the-nipple-in-juvenile-and-adolescent-scoliosis-patients
#9
JOURNAL ARTICLE
Ozden Bedre Duygu, Figen Govsa, Ahmet Bicer
BACKGROUND: The need for an objective set of anterior trunk measurements, such as nipple and clavicular shoulder joints, is essential to quantify the anterior asymmetry present in scoliosis. This study aims to characterize breast asymmetry (BA) in young individuals with scoliosis using photogrammetry. METHODS: Digital photographs of the anterior trunk of the 51 scoliosis patients aged 4-20 years were taken from an anterior perspective. These images were then transferred to a computer...
April 30, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38691173/application-of-high-frequency-ultrasound-to-evaluate-forehead-filling-materials
#10
JOURNAL ARTICLE
Li Yuan, Jun Zhuang, Qiaoyuan Zheng, Ying Jia, Xueshang Su, Qingqian Wei, Ziming Zhang, Jintian Hu, Hongli Chai
BACKGROUND: In recent years, soft tissue materials have been applied as forehead fillers. Some filling materials need to be removed or refilled in a timely manner in certain situations; therefore, it is important to develop a method to identify the location and type of filling materials. This study summarizes the imaging findings of different filling materials under high-frequency ultrasound, providing a reference for clinical treatment. METHODS: We screened facial ultrasound images performed at the Plastic Surgery Hospital of the Chinese Academy of Medical Sciences from April 2015 to July 2023 and classified and summarized the types of frontal filling materials and their imaging results...
April 30, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38691111/development-and-validation-of-18%C3%A2-f-psma-1007-pet-based-radiomics-model-to-predict-biochemical-recurrence-free-survival-following-radical-prostatectomy
#11
JOURNAL ARTICLE
Tiancheng Li, Mimi Xu, Shuye Yang, Guolin Wang, Yinuo Liu, Kaifeng Liu, Kui Zhao, Xinhui Su
PURPOSE: Biochemical recurrence (BCR) following radical prostatectomy (RP) is a significant concern for patients with prostate cancer. Reliable prediction models are needed to identify patients at risk for BCR and facilitate appropriate management. This study aimed to develop and validate a clinical-radiomics model based on preoperative [18 F]PSMA-1007 PET for predicting BCR-free survival (BRFS) in patients who underwent RP for prostate cancer. MATERIALS AND METHODS: A total of 236 patients with histologically confirmed prostate cancer who underwent RP were retrospectively analyzed...
May 1, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38690886/-52-mn-mn-bppa-trastuzumab-a-promising-her2-specific-pet-radiotracer
#12
JOURNAL ARTICLE
Ngô Minh Toàn, Adrienn Vágner, Gábor Nagy, Gábor Ország, Tamás Nagy, Csaba Csikos, Balázs Váradi, Gergő Zoltán Sajtos, István Kapus, Zoltán Szoboszlai, Dezső Szikra, György Trencsényi, Gyula Tircsó, Ildikó Garai
This study aimed to develop a novel radiotracer using trastuzumab and the long-lived [52 Mn]Mn isotope for HER2-targeted therapy selection and monitoring. A new Mn(II) chelator, BPPA, synthesized from a rigid bispyclen platform possessing a picolinate pendant arm, formed a stable and inert Mn(II) complex with favorable relaxation properties. BPPA was converted into a bifunctional chelator (BFC), conjugated to trastuzumab, and labeled with [52 Mn]Mn isotope. In comparison to DOTA-GA-trastuzumab, the BPPA-trastuzumab conjugate exhibits a labeling efficiency with [52 Mn]Mn approximately 2 orders of magnitude higher...
May 1, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38690825/a-giant-synovial-sarcoma-of-the-left-lung
#13
JOURNAL ARTICLE
Georgi Yankov, Magdalena Alexieva, Silvia Ivanova, Stefka Yankova, Evgeni Mekov
Primary pulmonary synovial sarcoma is an extremely rare and aggressive neoplasm that primarily affects young people and has a poor prognosis. Establishing this diagnosis requires the exclusion of a wide number of other neoplasms with multimodal clinical, imaging, histological, immunohistochemical, and cytogenetic assessment. We present a case of synovial sarcoma of the left lung in a 44-year-old man, diagnosed immunohistochemically after left lower lobectomy with atypical resection of the 5th segment. Imaging, diagnostic workup, histological and immunohistochemical characteristics, surgical treatment, and prognosis are discussed...
April 30, 2024: Folia Medica
https://read.qxmd.com/read/38690821/evaluation-of-calcium-hydroxide-root-canal-filling-materials-by-cone-beam-computed-tomography-and-three-dimensional-modeling
#14
JOURNAL ARTICLE
Asel Usdat Ozturk, Ekin Dogan, Venus Seyedoskuyi, Berk Senguler, Asli Topaloglu-Ak
The aim of this study was to compare the effectiveness of filling pastes in resin prototype primary molars by cone beam computed tomography (CBCT) and 3D modeling.
April 30, 2024: Folia Medica
https://read.qxmd.com/read/38690812/complications-due-to-ultrasound-transthoracic-cutting-biopsy-of-peripheral-pulmonary-lesions-and-lesions-in-the-chest-wall-and-mediastinum
#15
REVIEW
Dimcho Argirov, Boyko Yavorov, Vladimir Aleksiev, Anastas Chapkunov, Filip Shterev, Stanislav Kartev, Petar Uchikov, Zaprin Vazhev
Evaluation of patients with peripheral lung lesions and lesions of the chest wall and mediastinum is challenging. The nature of the lesion identified by imaging studies can be determined by histological evaluation of biopsies. An important place in this direction is the ever-increasing popularity among thoracic surgeons of the transthoracic biopsy with a cutting needle under ultrasound control (US-TTCNB).
April 30, 2024: Folia Medica
https://read.qxmd.com/read/38690811/factors-affecting-prediction-accuracy-of-postoperative-fev1-and-d-l-co-in-patients-undergoing-lung-resection
#16
JOURNAL ARTICLE
Anastas Chapkanov, Miroslava Todorova, Antoaneta Chirlova, Blagoi Marinov
Despite significant development in systemic therapy and radiotherapy, surgery is still the cornerstone for curative lung cancer treatment. Although predicted postoperative function (ppo) somewhat exactly correlates with actual postoperative function bigger differences may be a cause of serious clinical outcome.
April 30, 2024: Folia Medica
https://read.qxmd.com/read/38689835/pain-and-health-related-quality-of-life-in-autosomal-dominant-polycystic-kidney-disease-results-from-a-national-patient-powered-registry
#17
JOURNAL ARTICLE
Elise Hoover, Vanessa Holliday, Nicole Merullo, Dorothee Oberdhan, Ronald D Perrone, Chris Rusconi, Meyeon Park, Milind A Phadnis, Nadeesha Thewarapperuma, Neera K Dahl
RATIONALE & OBJECTIVE: Autosomal dominant polycystic kidney disease (ADPKD) affects health-related quality of life (HRQoL) including pain, discomfort, fatigue, emotional distress, and impaired mobility. Stakeholders prioritized kidney cyst-related pain as an important core outcome domain in clinical trials, leading to the development of disease-specific assessment tools. STUDY DESIGN: The ADPKD Registry is hosted online with multiple disease-specific patient-reported outcomes modules to characterize the patient experience in the United States...
May 2024: Kidney medicine
https://read.qxmd.com/read/38689449/bilateral-adrenal-metastasis-of-prostatic-adenocarcinoma-on-68ga-psma-pet-ct-imaging
#18
JOURNAL ARTICLE
Ediz Beyhan, Ceyda Turan Bektaş, Mehmet Can Baloğlu, Zehranur Tosunoğlu, Tevfik Fikret Çermik
An 84-year-old man with prostate adenocarcinoma underwent 68Ga-PSMA PET/CT due to PSA recurrence. Foci of 68Ga-PSMA uptake were observed in bilateral adrenal glands. Adrenal MRI showed metastasis only in the left adrenal gland. Metastatic 68Ga-PSMA uptake was also observed in the mediastinum and bone. Enzalutamide treatment was started. Follow-up 68Ga-PSMA PET/CT scan showed regression in both adrenal gland metastases and other metastases.
May 1, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38689445/two-cases-of-synchronous-hodgkin-lymphoma-and-papillary-thyroid-carcinoma-in-18f-fdg-pet-ct
#19
JOURNAL ARTICLE
Ru Wang, Haidong Cai, Changcun Liu, Zhongwei Lv, Chao Ma
The concurrence of Hodgkin lymphoma and papillary thyroid carcinoma is a rare clinical event. Two women presented with a painless mass in the neck that was suspected malignancy by ultrasonography. Both cases shown in the 18F-FDG PET/CT images demonstrated multiple foci of increased FDG uptake in the neck, mimicking thyroid carcinoma with contralateral cervical lymph node metastases. Unexpectedly, the postoperative pathologies confirmed the thyroid lesion of papillary carcinoma and contralateral cervical lymph nodes of classical Hodgkin lymphoma...
May 1, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38689441/intramuscular-granular-cell-tumor-detected-on-68ga-psma-pet-ct
#20
JOURNAL ARTICLE
Muge N Engin, Adil Boz
Finding of the prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer (PC) cells that have made it possible to evaluate the patients with PC with a single imaging method. 68Ga-PSMA PET/CT is now part of the routine in patients with PC. After several years of clinical experience with PSMA tracers, the specificity is satisfactory; however, concerns about the specificity are raising day by day due to the newly laid out nonprostatic malignant and benign lesions with high PSMA expression...
May 1, 2024: Clinical Nuclear Medicine
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