Wen-Yu Chuang, Hung Chang, Lee-Yung Shih, Tsung-Chieh Lin, Chi-Ju Yeh, Shir-Hwa Ueng, Ming-Chung Kuo, Hsiao-Wen Kao, Hsuan Liu, Sheng-Tsung Chang, Chih-Ling Lee, Kuan-Po Huang, Tong-Hong Wang, Yung-Liang Wan, Jau-Song Yu, Chuen Hsueh, Shih-Sung Chuang
Cyclin D1 protein-positive diffuse large B cell lymphoma (DLBCL) has an immunophenotype of CD5(-) cyclin D1(+) SOX11(-), and most cases lack a CCND1 rearrangement and have a gene expression profile of DLBCL. Rarely, cyclin D1 protein-positive DLBCL harbors a CCND1 rearrangement, and some genetic copy number features typical of mantle cell lymphoma (MCL) have been detected. Since gene expression studies have not been performed, whether such CCND1-rearranged cases represent cyclin D1 protein-positive DLBCL or CD5/SOX11 double-negative pleomorphic MCL remains unclear...
May 11, 2024: Virchows Archiv: An International Journal of Pathology