Mariana Alves, Beatriz Gil, Javier Villegas-Salmeron, Valentina Salari, Ricardo Martins-Ferreira, Marina Arribas Blázquez, Aida Menéndez Méndez, Rogerio Da Rosa Gerbatin, Jonathon Smith, Laura de Diego-Garcia, Giorgia Conte, Juan David Sierra Marquez, Paula Merino Serrais, Meghma Mitra, Ana Fernandez Martin, Yitao Wang, Jaideep Kesavan, Ciara Melia, Alberto Parras, Edward Beamer, Béla Zimmer, Mona Heiland, Brenton Cavanagh, Rafael Cipolat, James Morgan, Xinchen Teng, Jochen H M Prehn, Paolo Fabene, Giuseppe Bertini, Antonio R Artalejo, Esteban Ballestar, Annette Nicke, Luis A Olivos-Oré, Niamh M Connolly, David C Henshall, Tobias Engel
BACKGROUND: The purinergic ATP-gated P2X7 receptor (P2X7R) is increasingly recognized to contribute to pathological neuroinflammation and brain hyperexcitability. P2X7R expression has been shown to be increased in the brain, including both microglia and neurons, in experimental models of epilepsy and patients. To date, the cell type-specific downstream effects of P2X7Rs during seizures remain, however, incompletely understood. METHODS: Effects of P2X7R signaling on seizures and epilepsy were analyzed in induced seizure models using male mice including the kainic acid model of status epilepticus and pentylenetetrazole model and in male and female mice in a genetic model of Dravet syndrome...
May 20, 2024: Brain, Behavior, and Immunity