Xiang Yang Wu, Zhi Wei Zhang, Shan Nan Chen, An Ning Pang, Xue Yun Peng, Nan Li, Lan Hao Liu, Pin Nie
SIRT6, a key member of the sirtuin family, plays a pivotal role in regulating a number of vital biological processes, including energy metabolism, oxidative stress, and immune system modulation. Nevertheless, the function of SIRT6 in bony fish, particularly in the context of antiviral immune response, remains largely unexplored. In this study, a sirt6 was cloned and characterized in a commercial fish, the Chinese perch (Siniperca chuatsi). The SIRT6 possesses conserved SIR2 domain with catalytic core region when compared with other vertebrates...
May 29, 2024: Fish & Shellfish Immunology