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REVIEW
Lindsey A Fitzsimons, Delanie M Kneeland-Barber, Gracie C Hannigan, David A Karpe, Lyman Wu, Michael Colon, Jess Randall, Kerry L Tucker
Left ventricular noncompaction cardiomyopathy (LVNC) is a structural heart defect that has been associated with generation of arrhythmias in the population and is a cause of sudden cardiac death with severe systolic dysfunction and fatal arrhythmias. LVNC has gained increasing acknowledgment with increased prevalence. We conducted a systematic review of reported electrocardiogram (ECG) results for pediatric LVNC patients. EMBASE database query was performed, yielding 4531 articles related to LVNC between 1990 and December 2023...
May 2024: Physiological Reports
#2
REVIEW
Iva Minga, Mohammad A Al-Ani, Sarah Moharem-Elgamal, Aswathy Vaikom House Md, Ahmed Sami Abuzaid Md, Michael Masoomi, Saima Mangi
PURPOSE OF REVIEW: To provide an overview of the impact of virtual and augmented reality in contemporary cardiovascular medical practice. RECENT FINDINGS: The utilization of virtual and augmented reality has emerged as an innovative technique in various cardiovascular subspecialties, including interventional adult, pediatric, and adult congenital as well as structural heart disease and heart failure. In particular, electrophysiology has proven valuable for both diagnostic and therapeutic procedures...
April 29, 2024: Current Cardiology Reports
#3
JOURNAL ARTICLE
Merve Koç Yekedüz, Engin Köse, Aslı İnci, Merve Feyza Yüksel, Neslihan Doğulu, Birsel Şen Akova, Nurşah Yeniay Süt, Ümmühan Öncül, Miraç Yildirim, Suat Fitoz, Serap Teber, Leyla Tümer, Fatma Tuba Eminoğlu
BACKGROUND: One of the most common causes of carpal tunnel syndrome (CTS) in childhood is mucopolysaccharidosis (MPS). While ultrasonography (US) can aid in the diagnosis of CTS in adult patients, there is limited experience of this in the pediatric group. We aimed to investigate the results of wrist ultrasonography, which may be a candidate alternative to electrophysiological examination. METHODS: The participants were evaluated for symptoms, physical examination findings, electrophysiological tests and grayscale US...
April 5, 2024: Pediatric Neurology
#4
EDITORIAL
Shankar Baskar, Charles I Berul
Based on this robust study, one can conclude that symptomatic pediatric CPVT patients are at high risk for arrhythmic syncope, SCA and SCD even when receiving medical treatment. Compliance and underdosing with medications play a major role in these risks. LCSD may be underutilized in CPVT. ICDs are protective against these risks but at the cost of a high rate of appropriate and inappropriate shocks and other complications.
April 22, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#5
REVIEW
Jacopo Proietti, Geraldine B Boylan, Brian H Walsh
Early induced therapeutic hypothermia represents the cornerstone treatment in neonates with probable hypoxic-ischemic encephalopathy. The selection of patients for treatment usually involves meeting criteria indicating evidence of perinatal hypoxia-ischemia and the presence of moderate or severe encephalopathy. In this review, we highlight the variability that exists between some of the different regional and national eligibility guidelines. Determining the potential presence of perinatal hypoxia-ischemia may require either one, two or three signs amongst history of acute perinatal event, prolonged resuscitation at delivery, abnormal blood gases and low Apgar score, with a range of cutoff values...
April 22, 2024: Pediatric Research
#6
Yusaku Nagatomo, Susumu Takase, Kazuo Sakamoto, Hazumu Nagata, Kenichiro Yamamura, Hiroyuki Tsutsui, Shouichi Ohga
UNLABELLED: Non-reentrant fascicular tachycardia (NRFT) developed in a 6-year-old Japanese boy. Because of drug-resistant recurrences, he received catheter mapping and ablation at age 10 years. An electrocardiogram exhibited a superior left-axis deviation, a right bundle branch block-type configuration, and relatively narrow QRS with sharp R wave. It suggested verapamil-sensitive ventricular tachycardia (VT), but showed no sensitivity to verapamil or reentrant characteristics in the electrophysiological study...
April 2024: Journal of Cardiology Cases
#7
JOURNAL ARTICLE
Fabrizio Drago, Francesco Flore, Pietro Paolo Tamborrino, Massimo Stefano Silvetti, Stella Maiolo, Massimiliano Raponi
BACKGROUND: Cryoablation of APs localized near the atrioventricular (AV) junction is a well-established ablation strategy in children, and it has proved to be very safe. However, recurrence rates remain considerable for specific accessory pathway (AP) localizations. The aim of this retrospective study was to evaluate the efficacy and safety of a trans-jugular approach for cryoablation of right anterior, anterior-lateral, and anterior-septal APs in children, as compared to the conventional femoral approach...
April 20, 2024: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
#8
JOURNAL ARTICLE
Travis S CreveCoeur, Rajiv R Iyer, Hannah E Goldstein, Mychael W Delgardo, Todd C Hankinson, Mark A Erickson, Sumeet Garg, David L Skaggs, Lindsay Andras, Benjamin C Kennedy, Patrick J Cahill, Lawrence G Lenke, Peter D Angevine, Benjamin D Roye, Michael G Vitale, Anil Mendiratta, Richard C E Anderson
BACKGROUND CONTEXT: Intraoperative neurophysiological monitoring (IONM) is used to reduce the risk of spinal cord injury during pediatric spinal deformity surgery. Significant reduction and/or loss of IONM signals without immediate recovery may lead the surgeon to acutely abort the case. The timing of when monitorable signals return remains largely unknown. PURPOSE: The goal of this study was to investigate the correlation between IONM signal loss, clinical examination, and subsequent normalization of IONM signals after aborted pediatric spinal deformity surgery to help determine when it is safe to return to the operating room...
April 11, 2024: Spine Journal: Official Journal of the North American Spine Society
#9
JOURNAL ARTICLE
Avani Lamba, Thomas M Roston, Puck J Peltenburg, Dania Kallas, Sonia Franciosi, Krystien V V Lieve, Prince J Kannankeril, Minoru Horie, Seiko Ohno, Ramon Brugada, Takeshi Aiba, Peter Fischbach, Linda Knight, Jan Till, Sit-Yee Kwok, Vincent Probst, David Backhoff, Martin J LaPage, Anjan S Batra, Fabrizio Drago, Kristina Haugaa, Andrew D Krahn, Tomas Robyns, Heikki Swan, Terezia Tavacova, Joseph Atallah, Martin Borggrefe, Boris Rudic, Georgia Sarquella-Brugada, Ehud Chorin, Allison Hill, Janneke Kammeraad, Anna Kamp, Ian Law, James Perry, Jason D Roberts, Svjetlana Tisma-Dupanovic, Christopher Semsarian, Jonathan R Skinner, Jacob Tfelt-Hansen, Isabelle Denjoy, Antoine Leenhardt, Peter J Schwartz, Michael J Ackerman, Arthur A M Wilde, Christian van der Werf, Shubhayan Sanatani
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) may cause sudden cardiac death (SCD) despite medical therapy. Therefore, implantable cardioverter defibrillators (ICDs) are commonly advised. However, there are limited data on the outcomes of ICD use in children. OBJECTIVE: To compare the risk of arrhythmic events in pediatric CPVT patients with and without ICDs. METHODS: We compared the risk of SCD in RYR2 variant and phenotype positive symptomatic CPVT patients with and without ICDs, who were <19 years of age and had no history of sudden cardiac arrest (SCA) at phenotype diagnosis...
April 6, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#10
JOURNAL ARTICLE
Na-Na Liu, Jun-Jiao Zhang, Fan Zhang, Cong-Ying Wu, Yu-Wu Jiang
OBJECTIVES: To investigate the effects of different concentrations of adapalene on the morphology and functions of neuroblastoma cell line SH-SY5Y, as well as its role in inducing cell differentiation and apoptosis. METHODS: SH-SY5Y cells were divided into control group, low concentration (0.1 μM and 1 μM) adapalene groups, and high concentration (10 μM) adapalene group. Time-lapse microscopy was used to observe the morphological changes of SH-SY5Y cells...
March 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
#11
JOURNAL ARTICLE
Massimo Stefano Silvetti, Luigina Porco, Marta Campisi, Vincenzo Pazzano, Ilaria Tamburri, Fabio Anselmo Saputo, Giacomo Silvetti, Lucilla Ravà, Fabrizio Drago
BACKGROUND: The stretching of the lead caused by somatic growth may lead to complications (dislodgement, fracture, failure) of transvenous leads implanted in pediatric patients. Atrial loop and absorbable ligatures may prevent it. Periodical lead advancement with lead pushing from the pocket may be an option to growth-induced stretching. Our aim was to analyze retrospectively the outcome of periodical transvenous lead advancement in children with pacemaker (PM). METHODS: A procedure of lead advancement was performed in patients with a single-chamber PM implanted for isolated congenital complete atrioventricular block or sinus node dysfunction with growth-induced lead straightening/stretching...
March 29, 2024: Pacing and Clinical Electrophysiology: PACE
#12
JOURNAL ARTICLE
Veria Vacchiano, Francesca Morabito, Claudia Faini, Giovanna Nocera, Riccardo Not, Gaia Scarpini, Martina Romagnoli, Antonella Pini, Rocco Liguori
INTRODUCTION/AIMS: MScanFit MUNE (MScanFit) is a novel tool to derive motor unit number estimates (MUNEs) from compound muscle action potential (CMAP) scans. Few studies have explored its utility in 5q spinal muscular atrophy (SMA5q) patients, assessing only the abductor pollicis brevis (APB) muscle. We aimed to assess different distal muscles in pediatric and adult SMA5q patients, further evaluating clinical-electrophysiological correlations. METHODS: We analyzed MScanFit parameters reflecting the extent of denervation (MUNE; N50) and parameters of collateral reinnervation in APB, abductor digiti minimi (ADM), and tibialis anterior (TA) muscles...
March 29, 2024: Muscle & Nerve
#13
JOURNAL ARTICLE
E S Druzhinina, A A Kozyreva, R T Bembeeva, A S Kozlovsky, V E Sokolova, I V Isaev, A G Narbutov, N N Zavadenko, O A Tikhonova
N-Hexane is a solvent widely used in manufacturing as a cleaner, degreaser and component of rubber cement. Chronic exposure to n -hexane either through contact with unprotected skin or inhalation can lead to the development of clinical symptoms and electrophysiological changes similar to those of inflammatory demyelinating polyneuropathy which requires careful differential diagnosis. This article presents three cases of severe predominantly motor polyneuropathy with demyelinating features in 15- and 16-year-old adolescents...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#14
JOURNAL ARTICLE
Katharine C Simon, Chelsea Cadle, Neal Nakra, Marni C Nagel, Paola Malerba
Brain oscillations of non-rapid eye movement sleep, including slow oscillations (SO, 0.5-1.5 Hz) and spindles (10-16 Hz), mirror underlying brain maturation across development and are associated with cognition. Hence, age-associated emergence and changes in the electrophysiological properties of these rhythms can lend insight into cortical development, specifically in comparisons between pediatric populations and typically developing peers. We previously evaluated age-associated changes in SOs in male patients with Duchenne muscular dystrophy (DMD), finding a significant age-related decline between 4 and 18 years...
2024: Sleep advances: a journal of the Sleep Research Society
#15
JOURNAL ARTICLE
Stephanie Le, Carmen Menacho, Alessandro Prigione
In a recent study, Rylaarsdam and colleagues revealed that mutant PACS1 gene, which causes a rare neurodevelopmental syndrome, affects the firing ability of human neurons without dysregulating the cellular architecture of brain organoids. These findings suggest aberrant neuronal electrophysiology as a possible interventional target for pediatric diseases impairing brain development.
March 22, 2024: Trends in Neurosciences
#16
JOURNAL ARTICLE
Toni Brešković, Lucija Lisica, Zrinka Jurišić, Davor Petrović, Ivan Sikirić, Vitomir Metličić, Ante Anić
BACKGROUND: Ablation of accessory pathways (AP) is cornerstone for treatment of patients with Wolff-Parkinson-White Syndrome and manifestation of atrioventricular reentry tachycardia. Pulsed field ablation (PFA) is a new type of non-thermal form of energy source delivered to the underlying tissue via the ablation catheter and used for ablation of arrhythmic substrates. OBJECTIVE: We present the efficiency and long-term outcome of ablation of APs of different localizations using a focal pulsed electrical field...
March 16, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#17
Michael A Jensen, Anthony Fine, Panagiotis Kerezoudis, Lily Wong Kisiel, Eva Alden, Dora Hermes, Kai J Miller
INTRODUCTION: Stereoelectroencephalography (sEEG) has become the predominant method for intracranial seizure localization. When imaging, semiology, and scalp EEG are not in full agreement or definitively localizing, implanted sEEG recordings are used to test candidate seizure onset zones (SOZs). Discovered SOZs may then be targeted for resection, laser ablation, or neurostimulation. If a SOZ is eloquent, resection and ablation are both contraindicated, so identifying functional representation is crucial for therapeutic decision making...
March 11, 2024: bioRxiv
#18
JOURNAL ARTICLE
Eloïse Colnot, Julie O'Reilly, Didier Morin
Nanoparticles (NPs) possess unique properties that make their use valuable in all industries. Titanium dioxide (TiO2 ) NPs are extensively used as a white pigment in food (labeled under the European number E171) and personal care products, which creates a significant potential for chronic consumer exposure. Concerns about the potential toxic effects of TiO2 NPs have arisen, particularly in vulnerable populations, including pregnant women and infants. Recently, human materno-fetal transfer of E171 was demonstrated, and simultaneously, we reported that chronic prenatal exposure to reference P25 TiO2 NPs was found to alter the developing respiratory neural networks...
2024: Frontiers in Pediatrics
#19
JOURNAL ARTICLE
A A Kozyreva, R Ts Bembeeva, E S Druzhinina, N N Zavadenko, L M Kolpakchi, S V Pilia
OBJECTIVE: Analysis of demographic, clinical, laboratory, electrophysiological and neuroimaging data and pathogenetic therapy of pediatric patients with chronic inflammatory demyelinating polyneuropathy (CIDP). MATERIAL AND METHODS: Patients ( n =30) were observed in a separate structural unit of the Russian Children's Clinical Hospital of the Russian National Research Medical University named after. N.I. Pirogova Ministry of Health of the Russian Federation in the period from 2006 to 2023...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#20
JOURNAL ARTICLE
Kreeta Viinikainen, Pirjo Isohanni, Jukka Kanerva, Tuula Lönnqvist, Leena Lauronen
OBJECTIVE: Vincristine, a widely used anticancer chemotherapy drug, may cause polyneuropathy (PNP), potentially resulting in permanent functional impairment. We characterized the occurrence and development of vincristine-induced neuropathy (VIPN) in early treatment of childhood leukemia. METHODS: This prospective study of 35 pediatric acute lymphoblastic leukemia (ALL) patients comprised systematic clinical and electrophysiological studies at both the time of diagnosis and at least one time point during the first months of treatment...
2024: Clinical Neurophysiology Practice
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