Zhen Han, Zhicheng Zhang, Xianqi Yang, Zhe Li, Shengtian Sang, Md Tauhidul Islam, Alyssa A Guo, Zihan Li, Xiaoyan Wang, Jing Wang, Taojun Zhang, Zepang Sun, Lequan Yu, Wei Wang, Wenjun Xiong, Guoxin Li, Yuming Jiang
BACKGROUND: Only a subset of patients with gastric cancer experience long-term benefits from immune checkpoint inhibitors (ICIs). Currently, there is a deficiency in precise predictive biomarkers for ICI efficacy. The aim of this study was to develop and validate a pathomics-driven ensemble model for predicting the response to ICIs in gastric cancer, using H&E-stained whole slide images (WSI). METHODS: This multicenter study retrospectively collected and analyzed H&E-stained WSIs and clinical data from 584 patients with gastric cancer...
May 15, 2024: Journal for Immunotherapy of Cancer