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JOURNAL ARTICLE
Zhi Su, Hao-Ming Li, Meng-Meng Wang, Yan Su, Hong-Bao Fang
Mitochondria, recognized as the cellular powerhouses, are indispensable organelles responsible for crucial cellular processes, such as energy metabolism, material synthesis, and signaling transduction. Their intricate involvement in a broad spectrum of diseases, particularly cancer, has propelled the exploration of mitochondria-targeting treatment as a promising strategy for cancer therapy. Since the groundbreaking discovery of cisplatin, the trajectory of research on the development of metal complexes have been marked by continuous advancement, giving rise to a diverse array of metallodrugs characterized by variations in ligand types, metal center properties, and oxidation states...
May 2, 2024: ChemMedChem
#42
JOURNAL ARTICLE
Vinay Mathew Thomas, Yeonjung Jo, Nishita Tripathi, Soumyajit Roy, Beverly Chigarira, Arshit Narang, Georges Gebrael, Chadi Hage Chehade, Nicolas Sayegh, Gliceida Galarza Fortuna, Richard Ji, Patrick Campbell, Haoran Li, Neeraj Agarwal, Sumati Gupta, Umang Swami
IMPORTANCE: The treatment paradigm for advanced urothelial carcinoma (aUC) has undergone substantial transformation due to the introduction of effective, novel therapeutic agents. However, outcomes remain poor, and little is known about current treatment approaches and attrition rates for patients with aUC. OBJECTIVES: To delineate evolving treatment patterns and attrition rates in patients with aUC using a US-based patient-level sample. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study used patient-level data from the nationwide deidentified electronic health record database Flatiron Health, originating from approximately 280 oncology clinics across the US...
May 1, 2024: JAMA Network Open
#43
REVIEW
Eslam E Saad, Rachel Michel, Mostafa A Borahay
PURPOSE OF REVIEW: Since obesity is a major risk factor for many different types of cancer, examining one of the most closely associated comorbidities, such as hypercholesterolemia, is crucial to understanding how obesity causes cancer. Hypercholesterolemia is usually associated with many cardiovascular complications such as hypertension, angina, and atherosclerosis. In addition, cholesterol may be a major factor in increasing cancer risk. Cancer patients who received statins, an anti-hypercholesteremic medicine, demonstrated improved prognosis possibly through its effect on tumor proliferation, apoptosis, and oxidative stress...
May 2, 2024: Current Nutrition Reports
#44
JOURNAL ARTICLE
Bikang Yang, Juan Yang, Keqiang Zhang
PURPOSE: Cuproptosis, programmed cell death by intracellular copper-mediated lipoylated protein aggregation, is involved in various tumorigenesis and drug resistance abilities by mediating the tumor microenvironment. Previous studies have demonstrated that serum copper levels are higher in OC patients than in normal subjects. However, the exact relationship between cuproptosis and ovarian cancer progression remains to be further elucidated. METHODS: The Cancer Genome Atlas (TCGA) and gene expression omnibus (GEO) datasets were utilized to establish a cuproptosis-related prognostic signature in ovarian cancer...
May 2, 2024: Discover. Oncology
#45
JOURNAL ARTICLE
Barbara Gillis, Daphne Villanueva, Wallis Marsh, Faryal Afridi, Jessie Danforth, Megan Thornberg, Vishy Chaudhary, Rajeev Sharma
OBJECTIVES: Before the advent of direct-acting antiviral therapy for hepatitis C virus, a large proportion of kidneys from donors with hepatitis C viremia were discarded. Hepatitis C virus is now amenable to effective treatment with excellent seronegativity rates. In this study, we review the outcomes of hepatitis C viremic kidneys transplanted into hepatitis C-naive recipients. MATERIALS AND METHODS: In this retrospective observational study, we examined 6 deceased donor kidneys with hepatitis C viremia that were transplanted into hepatitis C-naive recipients between March 2020 and April 2021 at a single center...
March 2024: Experimental and Clinical Transplantation
#46
JOURNAL ARTICLE
Xiaoxi Fan, Jibo Han, Lingfeng Zhong, Wenyuan Zheng, Ruiyin Shao, Yucong Zhang, Si Shi, Shuang Lin, Zhouqing Huang, Weijian Huang, Xueli Cai, Bozhi Ye
BACKGROUND: Macrophages play a crucial role in atherosclerotic plaque formation, and the death of macrophages is a vital factor in determining the fate of atherosclerosis. GSDMD (gasdermin D)-mediated pyroptosis is a programmed cell death, characterized by membrane pore formation and inflammatory factor release. METHODS: ApoE -/- and Gsdmd -/- ApoE -/- mice, bone marrow transplantation, and AAV-F4/80-shGSDMD were used to examine the effect of macrophage-derived GSDMD on atherosclerosis...
May 2, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
#47
JOURNAL ARTICLE
K S Shohdy, M Pillai, K S Abbas, J Allison, T Waddell, E Darlington, S Mohammad, S Hood, S Atkinson, K Simpson, D Morgan, P Nathan, E Kilgour, C Dive, F Thistlethwaite
BACKGROUND: Predictive biomarkers for immune checkpoint blockade in the second-line treatment of metastatic renal cell carcinoma (mRCC) are lacking. MATERIALS AND METHODS: Patients with histologically confirmed RCC who started nivolumab after at least 4 months of tyrosine kinase inhibitors (TKIs) were recruited for this study. Serial tissue and blood samples were collected for immune biomarker evaluation. The primary endpoint was to determine the association of specific T-cell subsets with clinical outcomes tested using Wilcoxon rank sum for clinical benefit rate (CBR) and log-rank test for progression-free survival (PFS)...
June 2024: Immunooncol Technol
#48
REVIEW
Jingsong Shen, Hengsong Fu, Yanling Ding, Ziyang Yuan, Zeming Xiang, Miao Ding, Min Huang, Yongquan Peng, Tao Li, Kelan Zha, Qiang Ye
Ferroptosis is a newly discovered form of programmed cell death triggered by intracellular iron overload, which leads to the accumulation of lipid peroxides in various cells. It has been implicated in the pathogenesis and progression of various diseases, including tumors, neurological disorders, and cardiovascular diseases. The intricate mechanism underlying ferroptosis involves an imbalance between the oxidation and antioxidant systems, disturbances in iron metabolism, membrane lipid peroxidation, and dysregulation of amino acid metabolism...
June 2024: IJC Heart & Vasculature
#49
JOURNAL ARTICLE
Kotaro Sugawara, Takashi Fukuda, Chiaki Murakami, Daiji Oka, Takako Yoshii, Gulanbar Amori, Kumiko Ishibashi, Yasuhito Kobayashi, Hiroki Hara, Hiroaki Kanda, Noriko Motoi
With the advent of immune checkpoint inhibitors (ICIs), a better understanding of tumor microenvironment (TME) is becoming crucial in managing esophageal squamous cell carcinoma (ESCC) patients. We investigated the survival impact of TME status and changes in patients with ESCC who underwent neoadjuvant chemotherapy (NAC) followed by surgery (n = 264). We examined immunohistochemical status (CD4+ , CD8+ , CD20+ , Foxp3+ , HLA class-1+ , CD204+ , and programmed death ligand-1 [PD-L1+ ]) on 264 pre-NAC and 204 paired post-NAC specimens...
May 1, 2024: Cancer Science
#50
JOURNAL ARTICLE
Jiali Wang, Jingman Li, Lijie Yin, Xiuzhu Wang, Yue Dong, Guangfeng Zhao, Sunan Shen, Yayi Hou
BACKGROUND: Endometria are one of the important components of the uterus, which is located in the peritoneal cavity. Endometrial injury usually leads to intrauterine adhesions (IUA), accompanied by inflammation and cell death. We previously reported that both the endometrial ferroptosis was increased and monocytes/macrophages were involved in endometrial injury of IUA. Large peritoneal macrophages (LPMs) are recently reported to migrate into the injured tissues and phagocytose dead cells to repair the tissues...
May 1, 2024: Stem Cell Research & Therapy
#51
REVIEW
Ruiliang Chen, Yushuai Yu, Jie Zhang, Chuangui Song, Chuan Wang
BACKGROUND: Neoadjuvant treatment for hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer is controversial and requires a comprehensive analysis for optimal therapy assessment. Therefore, a two-step Bayesian network meta-analysis (NMA) was performed to compare the efficacy and safety of different neoadjuvant regimens. RESEARCH DESIGN AND METHODS: Phase II/III randomized clinical trials comparing various neoadjuvant therapies for HR+/HER2- breast cancer were included...
May 1, 2024: Expert Review of Anticancer Therapy
#52
REVIEW
Douglas J Hartman
Artificial intelligence/machine learning tools are being created for use in pathology. Some examples related to lung pathology include acid-fast stain evaluation, programmed death ligand-1 (PDL-1) interpretation, evaluating histologic patterns of non-small-cell lung carcinoma, evaluating histologic features in mesothelioma associated with adverse outcomes, predicting response to anti-PDL-1 therapy from hematoxylin and eosin-stained slides, evaluation of tumor microenvironment, evaluating patterns of interstitial lung disease, nondestructive methods for tissue evaluation, and others...
June 2024: Surgical Pathology Clinics
#53
REVIEW
Oana C Rosca, Oana E Vele
Since US Food and Drug Administration approval of programmed death ligand 1 (PD-L1) as the first companion diagnostic for immune checkpoint inhibitors (ICIs) in non-small cell lung cancer, many patients have experienced increased overall survival. To improve selection of ICI responders versus nonresponders, microsatellite instability/mismatch repair deficiency (MSI/MMR) and tumor mutation burden (TMB) came into play. Clinical data show PD-L1, MSI/MMR, and TMB are independent predictive immunotherapy biomarkers...
June 2024: Surgical Pathology Clinics
#54
JOURNAL ARTICLE
Xing Ye, Zi-Jie Lin, Guang-Hui Hong, Zhi-Min Wang, Run-Ting Dou, Jun-Yi Lin, Jian-Hui Xie, Yi-Wen Shen
Acute myocardial infarction (AMI) is a prevalent cardiovascular disease with high morbidity and mortality rates worldwide. Pyroptosis is an inflammatory form of programmed cell death that has been linked to various pathological conditions. However, its exact contribution to the onset and progression of heart injury in AMI has not yet fully elucidated. Herein, we established mouse AMI model by ligating the left anterior descending artery and performed transcriptome analysis during the early phase of AMI. Mouse HL-1 and human AC-16 cardiomyocytes were subjected to hypoxia to simulate ischemic injury in vitro...
April 29, 2024: Experimental Cell Research
#55
JOURNAL ARTICLE
Margherita Rimini, Gianluca Masi, Sara Lonardi, Federico Nichetti, Tiziana Pressiani, Daniele Lavacchi, Lucchetti Jessica, Guido Giordano, Mario Scartozzi, Emiliano Tamburini, Alessandro Pastorino, Ilario Giovanni Rapposelli, Bruno Daniele, Erika Martinelli, Ingrid Garajova, Giuseppe Aprile, Marta Schirripa, Vincenzo Formica, Francesca Salani, Costanza Winchler, Francesca Bergamo, Rita Balsano, Eleonora Gusmaroli, Angotti Lorenzo, Matteo Landriscina, Andrea Pretta, Ilaria Toma, Chiara Pirrone, Anna Diana, Francesco Leone, Oronzo Brunetti, Giovanni Brandi, Silvio Ken Garattini, Maria Antonietta Satolli, Federico Rossari, Lorenzo Fornaro, Monica Niger, Valentina Zanuso, Antonio De Rosa, Francesca Ratti, Luca Aldrighetti, Filippo De Braud, Silvia Foti, Mario Domenico Rizzato, Caterina Vivaldi, Cascinu Stefano, Lorenza Rimassa, Lorenzo Antonuzzo, Andrea Casadei-Gardini
BACKGROUND: The TOPAZ-1 phase III trial reported a survival benefit with the anti-programmed cell death ligand 1 (anti-PD-L1) durvalumab in combination with gemcitabine and cisplatin in patients with advanced biliary tract cancer (BTC). OBJECTIVE: The present study investigated for the first time the impact on survival of adding durvalumab to cisplatin/gemcitabine compared with cisplatin/gemcitabine in a real-world setting. PATIENTS AND METHODS: The analyzed population included patients with unresectable, locally advanced, or metastatic BTC treated with durvalumab in combination with cisplatin/gemcitabine or with cisplatin/gemcitabine alone...
May 1, 2024: Targeted Oncology
#56
JOURNAL ARTICLE
Shuangpeng Kang, Shuiping Jin, Xueying Mao, BinSheng He, Changyou Wu
Unlike T cells in other tissues, uterine T cells must balance strong immune defense against pathogens with tolerance to semiallogeneic fetus. Our previous study fully elucidated the characteristics of γδ T cells in nonpregnant uterus and the mechanism modulated by estrogen. However, comprehensive knowledge of the immunological properties of αβ T (including CD4+ T cells and CD8+ T) cells in nonpregnancy uterus has not been acquired. In this study, we fully compared the immunological properties of αβ T cells between uterus and blood using mouse and human sample...
2024: Journal of Immunology Research
#57
JOURNAL ARTICLE
Hexiao Tang, Eric Abston, Mozhdeh Sojoodi, Yongtao Wang, Derek J Erstad, Zenan Lin, Bryan C Fuchs, Kenneth K Tanabe, Michael Lanuti
OBJECTIVE: Previous studies have demonstrated synergistic antitumor effects of angiotensin system inhibition (ASI) combined with cisplatin therapy in pancreatic cancer. This study examines whether or not synergistic antitumor effects occur with combination ASI and cisplatin treatment in lung cancer, and whether or not ASI-induced changes in epithelial-mesenchymal transition play a role in the mechanism of this antitumor phenomenon. METHODS: A set of lung cancer cell lines representing a spectrum of epithelial to mesenchymal phenotypes were identified and characterized...
April 2024: JTCVS open
#58
JOURNAL ARTICLE
Hanxi Chen, Minyan Chen, Bangwei Zeng, Lili Tang, Qian Nie, Xuan Jin, Wenhui Guo, Lili Chen, Yuxiang Lin, Chuan Wang, Fangmeng Fu
INTRODUCTION: The programmed cell death (PCD) pathway plays an important role in restricting cancer cell survival and proliferation. However, limited studies have investigated the association between genetic variants in the 3'-untranslated region of the PCD pathway genes and breast cancer outcomes. METHODS: In this study, we genotyped 28 potentially functional single nucleotide polymorphisms (SNPs) in 23 PCD pathway genes in 1,177 patients with early-stage breast cancer (EBC) from a Han Chinese population...
2024: Frontiers in Immunology
#59
REVIEW
Moonil Son
In filamentous fungi, vegetative cell fusion occurs within and between individuals. These fusions of growing hyphae (anastomosis) from two individuals produce binucleated cells with mixed cytoplasm known as heterokaryons. The fate of heterokaryotic cells was genetically controlled with delicacy by specific loci named het (heterokaryon) or vic (vegetative incompatibility) as a part of self-/nonself-recognition system. When het loci of two individuals are incompatible, the resulting heterokaryotic cells underwent programmed cell death or showed severely impaired fungal growth...
2024: Mycobiology
#60
REVIEW
Lujian Zhu, Jing Zhou, Chen Yu, Lei Gu, Qin Wang, Hanglu Xu, Yin Zhu, Maodong Guo, Minli Hu, Wei Peng, Hao Fang, Haizhen Wang
Ferroptosis, a type of programmed cell death that relies on iron, is distinct in terms of its morphological, biochemical and genetic features. Unlike other forms of cell death, such as autophagy, apoptosis, necrosis, and pyroptosis, ferroptosis is primarily caused by lipid peroxidation. Cells that die due to iron can potentially trigger an immune response which intensifies inflammation and causes severe inflammatory reactions that eventually lead to multiple organ failure. In recent years, ferroptosis has been identified in an increasing number of medical fields, including neurological pathologies, chronic liver diseases and sepsis...
2024: Journal of Inflammation Research
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