James D Lewis, Scott G Daniel, Hongzhe Li, Fuhua Hao, Andrew D Patterson, Aaron Hecht, Colleen M Brensinger, Gary D Wu, Kyle Bittinger, Manreet Kaur, Themistocles Dassopoulos, Scott B Snapper, Joshua R Korzenik, Matthew Bohm, Laura Raffals, Poonam Beniwal-Patel, David Hudesman, Kirk Russ, Loren Brook, Joel Pekow, Raymond Cross, Uni Wong, Shrinivas Bishu, Meenakshi Bewtra, James D Lewis, Richard Duerr, Sumona Saha, Freddy Caldera, Elizabeth Scoville, Parakkal Deepak, Matthew Ciorba
BACKGROUND AND AIMS: Crohn's disease is associated with alterations in the gut microbiome and metabolome described as dysbiosis. We characterized the microbial and metabolic consequences of ileal resection, the most common Crohn's disease surgery. METHODS: Patients with and without intestinal resection were identified from the Diet to Induce Remission in Crohn's Disease and Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease studies. Stool samples were analyzed with shotgun metagenomics sequencing...
May 13, 2024: Cellular and Molecular Gastroenterology and Hepatology