keyword
https://read.qxmd.com/read/38641669/radiofrequency-ablation-of-parathyroid-adenoma-results-of-a-retrospective-analysis-of-60-patients
#41
JOURNAL ARTICLE
Haleh Chehrehgosha, Hossein Chegini, Iraj Heydari, Hojat Ebrahiminik, Rambod Salouti, Jafar Golzarian
PURPOSE: To present the effectiveness and safety of radiofrequency ablation (RFA) in parathyroid adenoma (PTA). MATERIALS AND METHODS: In this retrospective study, 60 patients with a single PTA were evaluated for changes in biochemical and ultrasonographic features up to 6 months after RFA of the lesion. Adenomas were ablated with an alternative technique so called "Nik jet dissection" which incorporates full hydrodissection and polar artery coagulation. Complications as well as the variations in biochemical data and nodule volumes were analyzed between baseline measurements and at each follow-up interval data (first day, 1, 3, and 6 months after ablation) were analyzed...
April 19, 2024: Cardiovascular and Interventional Radiology
https://read.qxmd.com/read/38640283/weighted-gene-co-expression-network-analysis-reveals-key-biomarkers-and-immune-infiltration-characteristics-for-bronchial-epithelial-cells-from-asthmatic-patients
#42
JOURNAL ARTICLE
Qianqian Liu, Xiaoli Tang, Haipeng Xu, Jie Wen, Yangyang Chen, Shoubin Xue
BACKGROUND: Asthma ranks among the most prevalent non-communicable diseases worldwide. Previous studies have elucidated the significant role of the immune system in its pathophysiology. Nevertheless, the immune-related mechanisms underlying asthma are complex and still inadequately understood. Thus, our objective was to investigate novel key biomarkers and immune infiltration characteristics associated with asthma by employing integrated bioinformatics tools. METHODS: In this study, we conducted a weighted gene co-expression network analysis (WGCNA) to identify key modules and genes potentially implicated in asthma...
April 19, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38640238/pth-treatment-before-cyclic-joint-loading-improves-cartilage-health-and-attenuates-load-induced-osteoarthritis-development-in-mice
#43
JOURNAL ARTICLE
Adrien Y Antoinette, Sophia N Ziemian, Allison R Brown, Erin B Hudson, Carolyn Chlebek, Timothy M Wright, Steven R Goldring, Mary B Goldring, Miguel Otero, Marjolein C H van der Meulen
Osteoarthritis (OA) treatment is limited by the lack of effective nonsurgical interventions to slow disease progression. Here, we examined the contributions of the subchondral bone properties to OA development. We used parathyroid hormone (PTH) to modulate bone mass before OA initiation and alendronate (ALN) to inhibit bone remodeling during OA progression. We examined the spatiotemporal progression of joint damage by combining histopathological and transcriptomic analyses across joint tissues. The additive effect of PTH pretreatment before OA initiation and ALN treatment during OA progression most effectively attenuated load-induced OA pathology...
April 19, 2024: Science Advances
https://read.qxmd.com/read/38639341/video-assisted-thoracoscopic-surgery-is-a-safe-and-feasible-technique-for-mediastinal-parathyroid-lesions
#44
JOURNAL ARTICLE
Salih Duman, Arda Sarıgül, Eren Erdoğdu, Berker Özkan, Adalet Demir, Murat Kara, S Alper Toker
Introduction: Hyperfunctional ectopic parathyroid glands in the mediastinum pose a challenge to diagnosis and require optimal surgical management. Video-assisted thoracoscopic surgery (VATS) has emerged as a promising minimally invasive approach, offering potential benefits in terms of both patient comfort and oncological principles. This study aimed to evaluate the effectiveness and safety of VATS for the treatment of hyperfunctional ectopic parathyroid glands in the mediastinum. Methods: Among the 538 patients with mediastinal tumors who underwent thoracoscopic surgery at Istanbul University (2008-2021), 11 exhibited hyperfunctional ectopic parathyroid glands...
April 19, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/38638771/gestational-ectopic-hyperparathyroidism-a-case-report-of-perioperative-and-perinatal-outcomes
#45
Kimitaka Shibue, Nozomi Kubo, Hiromi Oda, Etsuko Tanabe, Tsutomu Okada, Cheng-Long Huang, Toshihiro Higuchi, Akihiro Hamasaki, Nobuya Inagaki
In the realm of obstetric care, discerning the subtle signs of primary hyperparathyroidism (PHPT) amidst common pregnancy symptoms remains a formidable challenge. Our exploration into a case of gestational hypercalcemia peels back the layers of this complexity, revealing the clinical conundrum posed by overlapping gastrointestinal manifestations. The journey from diagnosis through surgical intervention to the resolution of symptoms underscores the importance of vigilance for PHPT in pregnant patients. This case further prompts consideration of gamma-aminobutyric acid (GABA) as a potential piece in the puzzle of persistent symptoms post-calcium normalization, inviting a broader dialogue on the intricacies of parathyroid pathology in pregnancy...
March 2024: Curēus
https://read.qxmd.com/read/38638336/cervicomediastinal-hematoma-atypical-presentation-of-a-parathyroid-carcinoma
#46
Martina Cicia, Giampaolo Papi, Alfredo Scillitani, Stefania Corrado, Pietro Locantore, Alfredo Pontecorvi
Parathyroid carcinoma (PC) is a rare endocrine neoplasm that typically presents with osteopenia/osteoporosis, nephrolithiasis, asthenia, and neuropsychiatric symptoms. We describe the case of a 48-year-old woman, presenting with a large painful hematoma in the cervicomediastinal area. The neck ultrasound (US) demonstrated a solid lesion measuring 40 × 80 × 55 mm, markedly hypoechoic, which extended from the right thyroid lobe to the mediastinum. The blood tests showed elevated serum calcium and parathyroid hormone (PTH) concentrations, consistent with hypercalcemic primary hyperparathyroidism...
April 2024: JCEM Case Rep
https://read.qxmd.com/read/38637809/economic-burden-of-patients-with-post-surgical-chronic-and-transient-hypoparathyroidism-in-the-united-states-examined-using-insurance-claims-data
#47
JOURNAL ARTICLE
Kathleen L Deering, Niccole J Larsen, Patrick Loustau, Blandine Weiss, Soraya Allas, Michael D Culler, Qing Harshaw, Deborah M Mitchell
BACKGROUND: Hypoparathyroidism (HP) is a rare endocrine disease commonly caused by the removal or damage of parathyroid glands during surgery and resulting in transient (tHP) or chronic (cHP) disease. cHP is associated with multiple complications and comorbid conditions; however, the economic burden has not been well characterized. The objective of this study was to evaluate the healthcare resource utilization (HCRU) and costs associated with post-surgical cHP, using tHP as a reference...
April 18, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38637449/correlation-between-serum-1-25-oh-2d3-serum-phosphorus-and-parathyroid-hormone-and-parathyroid-function-after-central-lymph-node-dissection-in-patients-with-papillary-thyroid-carcinoma
#48
JOURNAL ARTICLE
Hongmei Yu, Haiqiang Li, Weiwei Su, Zhiwei Xu, Mengqi Xu, Chen Hang, Xiuping Li
This work was to demonstrate the relationship between serum 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), serum phosphorus (SP), and parathyroid hormone (PTH) and parathyroid function after central lymph node dissection (CLND) in patients with papillary thyroid carcinoma (PTC). 200 PTC patients after CLND were included, who were rolled into a control group (CG) (n = 89 cases without hypoparathyroidism) and an observation group (OG) (n = 111 cases with complicated hypoparathyroidism). The 1,25(OH)2D3, SP, and PTH levels were detected, and the diagnostic effect of these indicators was assessed...
April 18, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38635114/familial-states-of-primary-hyperparathyroidism-an-update
#49
REVIEW
F Cetani, E Dinoi, L Pierotti, E Pardi
BACKGROUND: Familial primary hyperparathyroidism (PHPT) includes syndromic and non-syndromic disorders. The former are characterized by the occurrence of PHPT in association with extra-parathyroid manifestations and includes multiple endocrine neoplasia (MEN) types 1, 2, and 4 syndromes, and hyperparathyroidism-jaw tumor (HPT-JT). The latter consists of familial hypocalciuric hypercalcemia (FHH) types 1, 2 and 3, neonatal severe primary hyperparathyroidism (NSHPT), and familial isolated primary hyperparathyroidism (FIHP)...
April 18, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38635056/a-prospective-cross-sectional-study-on-hypocalcemia-after-total-thyroidectomy-in-patients-with-graves-disease-insights-on-secondary-hyperparathyroidism
#50
JOURNAL ARTICLE
Hiroyuki Yamashita, Shinya Sato, Hisakazu Shindo, Yusuke Mori, Kouichi Yoshimoto, Seigo Tachibana, Takashi Fukuda, Hiroshi Takahashi
PURPOSE: To investigate the parathyroid function and calcium (Ca) levels in the secondary hyperparathyroidism (SHPT) state in patients with Graves' disease. METHODS: We examined 31 consecutive patients with Graves' disease without chronic kidney disease, who were treated with total thyroidectomy. The patients were divided into a normal parathyroid hormone (PTH) group (NPTH group; n = 19) with a PTH level ≤ 65 pg/mL, and a secondary hyperparathyroidism group (SHPT group; n = 12), with a PTH level > 65 pg/mL...
April 18, 2024: Surgery Today
https://read.qxmd.com/read/38633760/heterogeneity-and-high-prevalence-of-bone-manifestations-and-bone-mineral-density-in-congenital-generalized-lipodystrophy-subtypes-1-and-2
#51
JOURNAL ARTICLE
Erika Bastos Lima Freire, Catarina Brasil d'Alva, Mayara Ponte Madeira, Grayce Ellen da Cruz Paiva Lima, Virginia Oliveira Fernandes, Lindenberg Barbosa Aguiar, Leonardo Barreira Portella, Renan Galvão Ozório, Clarisse Mourão Melo Ponte, Ana Paula Dias Rangel Montenegro, Renan Magalhães Montenegro Junior
INTRODUCTION: Congenital Generalized Lipodystrophy (CGL) is a rare autosomal recessive disease caused by mutations in genes responsible for the formation and development of adipocytes. Bone abnormalities are described. However, there is a scarcity of data. OBJECTIVE: To describe bone characteristics in a large CGL1 and 2 case series. METHODS: Cross-sectional study that assessed bone radiological features of CGL patients of a reference hospital in Fortaleza (CE), Brazil...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38632671/health-related-quality-of-life-in-paediatric-patients-on-peritoneal-dialysis-data-from-a-tertiary-centre
#52
JOURNAL ARTICLE
Elias Hajj, Marijke Awouters, Melodie Mosca, Sacha Flammier, Sarra Rachedi, Justine Bacchetta, Aurelie De Mul, Bruno Ranchin
Kidney failure has a negative impact on both children and families' quality of life (QOL). We evaluated the burden of home peritoneal dialysis (PD) using two local questionnaires and the French version of PedsQL3.0 end-stage kidney disease module and family impact module. Data are expressed as median (min-max). We reviewed the charts of 12 patients, at a median age of 8.8 (1.2-16.7) years, undergoing maintenance PD for 8 (1-42) months. Parathyroid hormone and haemoglobin levels were 215 (17-606) ng/L and 117 (104-141) g/L, respectively...
April 17, 2024: Peritoneal Dialysis International
https://read.qxmd.com/read/38632144/meat-consumption-and-the-risk-of-hip-fracture-in-women-and-men-two-prospective-swedish-cohort-studies
#53
JOURNAL ARTICLE
Eva Warensjö Lemming, Liisa Byberg, Jonas Höijer, John A Baron, Alicja Wolk, Karl Michaëlsson
PURPOSE: To study the association between meat intake (predominantly red and processed meats) and the risk of hip fracture, as well as the association between meat intake and biomarkers of inflammation, oxidative stress, bone turnover, body composition, and bone mineral density (BMD). METHODS: Data from the Swedish Mammography Cohort and the Cohort of Swedish men (n = 83,603, 54% men) with repeated investigations and their respective clinical sub-cohorts was utilised...
April 17, 2024: European Journal of Nutrition
https://read.qxmd.com/read/38630876/load-carriage-exercise-increases-calcium-absorption-and-retention-in-healthy-young-women
#54
JOURNAL ARTICLE
Erin Gaffney-Stomberg, Anna T Nakayama, Laura J Lutz, James P McClung, Kimberly O O'Brien, Jeffery S Staab
Aerobic exercise reduces circulating ionized Ca (iCa) and increases parathyroid hormone (PTH), but the cause and consequences on Ca handling are unknown. The objective of this study was to determine the effects of strenuous exercise on Ca kinetics using dual stable Ca isotopes. Twenty-one healthy women (26.4 ± 6.7 yr) completed a randomized, crossover study entailing two 6-d iterations consisting of either 60 min of treadmill walking at 65% VO2max wearing a vest weighing 30% body weight on study days 1, 3, and 5 (exercise [EX]), or a rest iteration (rest [REST])...
March 4, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38628858/a-case-report-of-mediastinal-parathyroid-carcinoma-in-a-chronic-kidney-disease-patient-addressing-management-conundrum
#55
Chukwunonso Ezeani, Gift Echefu, Ifeoluwa Stowe, Damodar Kumbala, Shatha Murad
Parathyroid carcinoma is a rare malignancy; and it is rarer to find one located in an ectopic location. Ectopic parathyroid glands are a reported cause of failed primary surgery for hyperparathyroidism. We report here a 73-year-old male who previously had parathyroidectomy for primary hyperparathyroidism but then had recurrence of his symptoms with a diagnosis of a mediastinal parathyroid carcinoma on further evaluation. This presentation of complicated mediastinal parathyroid carcinoma posed significant diagnostic and management challenges due to comorbid stage IV chronic kidney disease (CKD)...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38628608/imaging-features-and-surgical-management-of-giant-parathyroid-adenoma-with-autoinfarction
#56
Tapan Patel, Rachelle Wolk, Nicole A Cipriani, Elizabeth Blair, Daniel Thomas Ginat
Autoinfarction of a parathyroid adenoma can have an atypical clinicoradiologic features that can mimic an inflammatory process or malignancy. In addition, the associated fibrosis makes surgical resection more challenging than for regular parathyroid adenomas. The implications of these findings are that while autoinfarction of parathyroid adenomas is a rare phenomenon, this entity should be considered when there are heterogeneous and cystic components on imaging in patients without hypercalcemia. Ultimately, histopathology is necessary for definitive diagnosis...
2024: Journal of Clinical Imaging Science
https://read.qxmd.com/read/38628593/lipoprotein-alterations-in-endocrine-disorders-a-review-of-the-recent-developments-in-the-field
#57
REVIEW
Michal Olejarz, Ewelina Szczepanek-Parulska, Marek Ruchala
Dyslipidemia is one of the most common disorders worldwide, which, if left untreated, results in a multitude of complications. Thus proper diagnostics, which includes identifying of secondary causes of dyslipidemia is crucial. Endocrine disorders are an important cause of secondary dyslipidemia. This paper aims to review the publications on lipoprotein alterations in endocrine disorders from the past two years and provide an overview of the recent discoveries in this dynamically developing and large field. Significant changes in lipoprotein serum concentrations are present in most endocrinological diseases and can be modified with proper treatment...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38627802/thoracoscopic-resection-of-paraesophageal-ectopic-mediastinal-parathyroid-adenoma-in-the-superior-posterior-mediastinum-a-case-report
#58
JOURNAL ARTICLE
Kai Fu, Xin-Yu Zhu, Xin-Yu Jia, Kun-Peng Feng, Yuan Cui, Jun Zhao, Chang Li
BACKGROUND: The ectopic superior parathyroid in the tracheoesophageal groove and paraesophageal region is rare. Hyperparathyroidism results when these glands become hyperfunctioning. That may necessitate surgical intervention in the form of parathyroidectomy, which requires a transsternal or transthoracic approach due to a deeply seated mediastinal parathyroid gland. Minimally invasive strategies have emerged recently as an alternative approach with less morbidity. CASE PRESENTATION: We present a case of the paraesophageal ectopic parathyroid gland in the superior posterior mediastinum, which was successfully treated with thoracoscopic resection...
April 16, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38626969/impact-of-supplementation-with-iron-folic-acid-ifa-and-vitamin-d-3-compared-with-ifa-alone-on-haemoglobin-levels-in-elderly-people-with-mild-to-moderate-anaemia-protocol-for-the-double-blind-randomised-placebo-controlled-iron-and-vitamin-d-trial-in-elderly
#59
JOURNAL ARTICLE
Farhad Ahamed, Abhishek Jaiswal, Sibasish Sahoo, Tandra Ghosh, Amandeep Kaur, Tanveer Rehman, Kalyan Goswami
INTRODUCTION: Anaemia in the elderly is often difficult to treat with iron supplementation alone as prevalence of anaemia of chronic disease (ACD) alone or mixed with iron-deficiency anaemia (IDA) is high in this age group. Hepcidin remains high in ACD, preventing utilisation of iron for heme synthesis. Vitamin D3 has shown hepcidin suppression activity in both in vitro and in vivo studies. As there is no study assessing the effect of iron-folic acid (IFA) with vitamin D3 on haemoglobin levels in the elderly in India, we want to conduct this study to estimate the impact of supplementation of a therapeutic package of IFA and vitamin D3 on haemoglobin levels in the elderly with mild-to-moderate anaemia in comparison with IFA only...
April 16, 2024: BMJ Open
https://read.qxmd.com/read/38625007/us-guided-percutaneous-radiofrequency-ablation-for-secondary-hyperparathyroidism-long-term-outcomes-and-prognostic-factors
#60
JOURNAL ARTICLE
Wenwen Yue, Tingting Jiang, Zisheng Ai, Erya Deng, Huihui Chai, Xiaolong Li, Hongfeng He, Zhengxian Zhang, Ning Weng, Xiachuan Qin, Jing Fan, Xiaoqing Tang, Wei Heng, Yong Li, Liping Sun, Chengzhong Peng, Huixiong Xu
Background Although favorable outcomes have been reported with radiofrequency ablation (RFA) for secondary hyperparathyroidism (SHPT), the long-term efficacy remains insufficiently investigated. Purpose To evaluate the long-term efficacy and safety of US-guided percutaneous RFA in patients with SHPT undergoing dialysis and to identify possible predictors associated with treatment failure. Materials and Methods This retrospective study included consecutive patients with SHPT with at least one enlarged parathyroid gland accessible for RFA who were undergoing dialysis at seven tertiary centers from May 2013 to July 2022...
April 2024: Radiology
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