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JOURNAL ARTICLE
Misael Vargas-López, Carlos A Quiroz-Vicente, Nury Pérez-Hernández, Fernando Gómez-Chávez, Angel E Bañuelos-Hernández, Elizabeth Pérez-Hernández
Chondrosarcoma (CS) is a malignant bone tumor arising from cartilage-producing cells. The conventional subtype of CS typically develops within a dense cartilaginous matrix, creating an environment deficient in oxygen and nutrients, necessitating metabolic adaptation to ensure proliferation under stress conditions. Although ketone bodies (KBs) are oxidized by extrahepatic tissue cells such as the heart and brain, specific cancer cells, including CS cells, can undergo ketolysis. In this study, we found that KBs catabolism is activated in CS cells under nutrition-deprivation conditions...
May 15, 2024: Heliyon
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REVIEW
Lee M Jeys, Joachim Thorkildsen, Vineet Kurisunkal, Ajay Puri, Pietro Ruggieri, Matthew T Houdek, Richard A Boyle, Walid Ebeid, Eduardo Botello, Guy V Morris, Minna K Laitinen, Adesegun Abudu, Keisuke Ae, Manish Agarwal, Vivek Ajit Singh, Toru Akiyama, Jose I Albergo, John Alexander, Bugra Alpan, Ahmed Aoude, Apichat Asavamongkolkul, William Aston, Thomas Baad-Hansen, Tessa Balach, Joseph Benevenia, Peter Bergh, Nicholas Bernthal, Odion Binitie, Michele Boffano, Jos Bramer, Harriet Branford White, Bernadette Brennan, Jorge Cabrolier, Jose A Calvo Haro, Domenico A Campanacci, Rodrigo Cardoso, Richard Carey Smith, Nicolas Casales Fresnga, Jose M Casanova, Oscar Ceballos, Chung M Chan, Yang-Guk Chung, Miguel A Clara-Altamirano, Gillian Cribb, Solomon Dadia, Dietmar Dammerer, Marieke de Vaal, Javier Delgado Obando, Shaneel Deo, Claudia Di Bella, Davide M Donati, Makoto Endo, Levent Eralp, Bulent Erol, Scott Evans, Will Eward, Fabrice Fiorenza, Joao Freitas, Philipp T Funovics, Marcos Galli Serra, Michelle Ghert, Kanishka Ghosh, Luis C Gomez Mier, Jesus Gomez Vallejo, Anthony Griffin, Ashish Gulia, Maurice Guzman, Jendrik Hardes, John Healey, Adriana Hernandez, Asle Hesla, Chindanai Hongsaprabhas, Francis Hornicek, Keith Hosking, Shintaro Iwata, Jake Jagiello, Luke Johnson, Andy Johnston, Min Joo, Paul Jutte, Bilal Kapanci, Zeeshan Khan, Hiroshi Kobayashi, Yehuda Kollender, Sebastian Koob, Daniel Kotrych, Louis-Romee Le Nail, Pawel Legosz, Burkhard Lehner, Andreas Leithner, Valerae Lewis, Peng Lin, Francisco Linares, Santiago Lozano Calderon, Ashish Mahendra, Ferdiansyah Mahyudin, Eric Mascard, Jean-Camille Mattei, Louise McCullough, Manuel R Medellin Rincon, Rhidian Morgan-Jones, Diego J Moriel Garcesco, Sophie Mottard, Robert Nakayama, Prashant Narhari, Gary O'Toole, Oliveira Vania, André Olivier, Mohamed Omar, Eduardo Ortiz-Cruz, Harzem Ozger, Korhan Ozkan, Emanuela Palmerini, Panayiotis Papagelopoulos, Michael Parry, Sam Patton, Michael M Petersen, Gerard Powell, Mark Puhaindran, Anand Raja, Raja B Rajasekaran, Lauris Repsa, Mickael Ropars, Andrea Sambri, Thomas Schubert, Ahmad Shehadeh, Geoffrey Siegel, Scott Sommerville, Andre Spiguel, Jonathan Stevenson, Gwen Sys, Thomas Temple, Frank Traub, Hiroyuki Tsuchiya, Juan Valencia, Michel Van de Sande, Gualter Vaz, Roberto Velez Villa, Oleg Vyrva, Hazem Wafa, Wan I Wan Faisham Numan, Edward Wang, David Warnock, Joel Werier, Kwok-Chuen Wong, Yamamoto Norio, Ye Zhaoming, Suraya Zainul Abidin, Tomas Zamora, Juan P Zumarraga, Ghaith Abou-Nouar, Carsten Gebert, R L Randall
Chondrosarcoma is the second most common surgically treated primary bone sarcoma. Despite a large number of scientific papers in the literature, there is still significant controversy about diagnostics, treatment of the primary tumour, subtypes, and complications. Therefore, consensus on its day-to-day treatment decisions is needed. In January 2024, the Birmingham Orthopaedic Oncology Meeting (BOOM) attempted to gain global consensus from 300 delegates from over 50 countries. The meeting focused on these critical areas and aimed to generate consensus statements based on evidence amalgamation and expert opinion from diverse geographical regions...
May 1, 2024: Bone & Joint Journal
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JOURNAL ARTICLE
Israel O Falade, Jacquelyn A Knox, Merisa L Piper, William Y Hoffman, Scott L Hansen
PURPOSE: Resection of sacral neoplasms such as chordoma and chondrosarcoma with subsequent reconstruction of large soft tissue defects is a complex multidisciplinary process. Radiotherapy and prior abdominal surgery play a role in reconstructive planning; however, there is no consensus on how to maximize outcomes. In this study, we present our institution's experience with the reconstructive surgical management of this unique patient population. METHODS: We conducted a retrospective review of patients who underwent reconstruction after resection of primary or recurrent pelvic chordoma or chondrosarcoma between 2002 and 2019...
May 1, 2024: Annals of Plastic Surgery
#4
REVIEW
Jiawei Yin, Peng Ren
Bone sarcomas encompass a group of spontaneous mesenchymal malignancies, among which osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma are the most common subtypes. Chondrosarcoma, a relatively prevalent malignant bone tumor that originates from chondrocytes, is characterized by endogenous cartilage ossification within the tumor tissue. Despite the use of aggressive treatment approaches involving extensive surgical resection, chemotherapy, and radiotherapy for patients with osteosarcoma, chondrosarcoma, and chordoma, limited improvements in patient outcomes have been observed...
April 1, 2024: Journal of Cancer Research and Therapeutics
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JOURNAL ARTICLE
Yue Yin, Yang Zhao, Xu Tian, Yong Zhao, Hanlin Chen, Liqin Zhang, Zhiqiang Gao, Guodong Feng
Objective: To summarize the results of different facial nerve management modalities applied to tumor resection in the jugular foramen region. Methods: The clinical data of 54 patients with tumors in the jugular foramen region who underwent surgery from January 2015 to March 2023 were retrospectively analyzed: 18 males and 36 females; Age ranges from 21 to 67 years, with an average age of 44.4 years; and median follow-up time: 12 months. The House-Brackmann（HB） grading system was applied to assess the patients' facial nerve function before surgery, 1-2 weeks after surgery and at the final follow-up （HBⅠ-Ⅱ grade for good function）: 42 cases with preoperative HB grades Ⅰ-Ⅱ; partial facial nerve transposition（9 cases）, complete facial nerve transposition（28 cases）, and facial nerve excision and re-construction（17 cases） were used, respectively（stage Ⅰor Ⅱ）...
May 2024: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
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JOURNAL ARTICLE
Peng Xu, Guangmao Yu, Haiyong Wang, Qiye Jia, Zhifeng Ma
INTRODUCTION: Primary chest wall tumors account for 5% of all thoracic neoplasms and 1% of all primary tumors. Chondrosarcoma is a rare solid tumor, with an annual incidence of <0.5 per million people per year. It predominantly occurs in the pelvis and femur, occasionally occurs in flat bones such as the sternum and ribs, and rarely invades lung tissue. Chest wall chondrosarcomas represent only 5-15% of all chondrosarcomas. Radical surgery often leads to a large range of chest wall defects, especially when the range exceeds 6 cm × 6 cm and involves the sternum, spine, or multiple consecutive ribs...
2024: Annali Italiani di Chirurgia
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JOURNAL ARTICLE
L Li, M Zhang, T T Zhang, Y Ding
Objective: To investigate the clinical application of EWSR1 gene rearrangement by fluorescence in situ hybridization (FISH) in bone and soft tissue tumors and to analyze the cases with atypical signal pattern. Methods: The cases detected for EWSR1 gene rearrangement by FISH in Beijing Jishuitan Hospital, Capital Medical University from 2014 to 2021 were collected, and the value of detecting EWSR1 gene rearrangement for diagnosing bone and soft tissue tumors was analyzed. The cases with atypical positive signals were further analyzed by next generation sequencing (NGS)...
May 8, 2024: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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JOURNAL ARTICLE
Arman Vahabi, Hüseyin Kaya, Hakan Koray Tosyalı, Burçin Keçeci, Dündar Sabah
BACKGROUND: Malignancies involving the pelvic ring present numerous challenges, especially in the periacetabular area. Extensive resection of the pelvic region without reconstruction can lead to severe functional impairment. Numerous reconstructive options exist, but all have drawbacks. Extracorporeally irradiated autografts are one option for reconstruction after periacetabular resections; they offer the potential advantages of eliminating the risk of allogeneic reactions associated with allografts and preserving local anatomy...
April 26, 2024: Clinical Orthopaedics and related Research
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Umayr Shaikh, Payal Shah, Victoria Jones, Alvaro J Ramos-Rodriguez, Aravindhan Sriharan, Eric Loo, Wahab A Khan, Brian Simmons, Jeffrey M Cloutier
Melanoma's rare capacity to undergo heterologous differentiation can create significant diagnostic challenges. The molecular mechanisms underlying this phenomenon are not well understood. We present an unusual case of subungual melanoma exhibiting extensive cartilaginous differentiation and provide insights into its molecular and cytogenomic features. Histopathologically, the tumor was predominantly composed of nodules of malignant cartilage in association with a smaller population of nested epithelioid to rhabdoid cells...
April 26, 2024: Journal of Cutaneous Pathology
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JOURNAL ARTICLE
Vivek Ajit Singh, Vinesh Sandhu, Choo Tze Yong, Nor Faissal Yasin
INTRODUCTION: The foot is a complex structure composed of several tissues, each of which can be the origin of the proliferation and development of the tumour. Most lesions about the foot are reactive or inflammatory, but some are true neoplasms. METHOD: This is a retrospective analysis of 4997 patient records treated in the Orthopaedic Oncology Unit of University Malaya Medical Centre, Malaysia, between 1 January 2010 to 31 December 2020. Demographic data of 195 patients with foot tumours were analysed out of 4997 neoplasm patients...
2024: Journal of Orthopaedic Surgery
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JOURNAL ARTICLE
El Omri Malika, Marwa Ben Njima, Bellakhdher Mouna, Nfikha Zeineb, Kemani Wassim, Sriha Badreddine, Abdelkefi Mohamed
Background: Chondrosarcomas are slow-growing malignant tumors that originate in cartilaginous structures. They typically manifest in the head and neck region, with a preference for the maxillofacial skeleton, particularly the mandible and maxilla. However, chondrosarcoma of the sinonasal tract is exceptionally rare, and only few cases have been reported. Case Presentation: This report details the case of a 43-year-old woman who incidentally discovered chondrosarcoma in the maxillary and ethmoid sinuses with nasal extension...
April 24, 2024: Ear, Nose, & Throat Journal
#12
REVIEW
Camillo Fulchignoni, Silvia Pietramala, Ivo Lopez, Giovan Giuseppe Mazzella, Chiara Comisi, Carlo Perisano, Lorenzo Rocchi, Tommaso Greco
Bone tumors of the upper limb are a common cause of bone pain and pathological fractures in both old and young populations. Surgical reconstruction and limb salvage have become valid options for these patients despite this kind of surgery being challenging due to the need for wide bone resection and the involvement of surrounding soft tissues. Computer-assisted technology helps the surgeon in pre-operative planning and in designing customized implants. The aim of this study was to investigate the surgical outcomes and complications of custom-made prostheses in oncologic reconstruction of the upper limb and if they are reliable options for patients suffering from aggressive tumors...
April 11, 2024: Journal of Functional Morphology and Kinesiology
#13
Yeting Qiu, Aijun Qin, Ronghua Zhao, Jun Ding, William Wei-Guo Jia, Manu Singh, Yanal Murad, Qian Tan, Ganessan Kichenadasse
Sarcoma is derived from mesenchymal neoplasms and has numerous subtypes, accounting for 1% of all adult malignancies and 15% of childhood malignancies. The prognosis of metastatic or recurrent sarcoma remains poor. The current study presents two cases of sarcoma enrolled in a phase I dose escalation trial for solid tumor, who had previously failed all standard therapies. These patients were treated with VG161, an immune-stimulating herpes simplex virus type 1 oncolytic virus with payloads of IL-12, IL-15 and IL-15 receptor α unit, and a programmed cell death 1 (PD-1)/PD-1 ligand 1 blocking peptide...
June 2024: Oncology Letters
#14
JOURNAL ARTICLE
Xiaoli Li, Xianglong Shi, Yanmei Wang, Jing Pang, Xia Zhao, Yuchao Xu, Qiyuan Li, Ning Wang, Feng Duan, Pei Nie
OBJECTIVE: The preoperative identification of tumor grade in chondrosarcoma (CS) is crucial for devising effective treatment strategies and predicting outcomes. The study aims to build and validate a CT-based radiomics nomogram (RN) for the preoperative identification of tumor grade in CS, and to evaluate the correlation between the RN-predicted tumor grade and postoperative outcome. METHODS: A total of 196 patients (139 in the training cohort and 57 in the external validation cohort) were derived from three different centers...
April 11, 2024: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
#15
João Martins Gama, Rui Caetano Oliveira, Rúben Fonseca, Maria Augusta Cipriano, José Casanova
Extraskeletal myxoid chondrosarcoma is a rare soft tissue tumour with a high local and distant metastasis rate and limited response to chemotherapy. Meckel's diverticulum is the most frequent congenital anomaly, and it is associated with a considerable risk of malignant transformation. In this case report, we describe a 50-year-old female patient with a history of extraskeletal myxoid chondrosarcoma of the lower limb and metastasis to the forearm who went to the emergency department with abdominal pain. The investigations revealed a caecal volvulus...
2024: Revista Española de Patología
#16
JOURNAL ARTICLE
Adam Haydel, Randall Craver, Matthew Cable
Fibrocartilaginous dysplasia (FCD) is a variant of fibrous dysplasia that often involves the proximal femur in young adults. It has a similar appearance on imaging as other entities but has stippled calcifications within the lesion. The differential diagnosis often includes benign and malignant tumors such as fibrous dysplasia, chondroblastoma, enchondroma, and chondrosarcoma. Histology is required for diagnosis and treatment is typically surgical due to the potential for pain, pathologic fracture, and deformity...
April 8, 2024: Fetal and Pediatric Pathology
#17
Masatoshi Nakamura, Masashi Mizumoto, Takashi Saito, Shosei Shimizu, Yinuo Li, Yoshiko Oshiro, Masako Inaba, Sho Hosaka, Hiroko Fukushima, Ryoko Suzuki, Takashi Iizumi, Kei Nakai, Kazushi Maruo, Hideyuki Sakurai
INTRODUCTION: Chondrosarcoma is a rare malignant bone tumor. Particle beam therapy (PT) can concentrate doses to targets while reducing adverse events. A meta-analysis based on a literature review was performed to examine the efficacy of PT and photon radiotherapy for skull base chondrosarcoma. METHODS: The meta-analysis was conducted using 21 articles published from 1990 to 2022. RESULTS: After PT, the 3- and 5-year overall survival (OS) rates were 94...
2024: Frontiers in Oncology
#18
JOURNAL ARTICLE
Minami Hirasawa, Yoshinao Kikuchi, Kenji Sato, Akihiko Yoshida, Asako Yamamoto
We present a new, extremely rare nonmyxoid cellular variant of extraskeletal myxoid chondrosarcoma. Although diagnosis is radiologically and pathologically challenging, FDG PET/CT and MRI accurately showed the malignancy and high tumor density. A 52-year-old woman complained of a left dorsal mass, which presented inhomogeneous intermediate signals on T2-weighted images, with diffusion restriction, strong enhancement, and increased accumulation of FDG (SUVmax, 5.2). Although biopsy was inconclusive, a highly malignant tumor was suspected radiologically...
April 1, 2024: Clinical Nuclear Medicine
#19
EDITORIAL
Scott E Kilpatrick
There is no shortage of comprehensive review articles on bone and soft tissue pathology, almost always representing a regurgitation of the literature with little to no guidance on personal "best practices," recommended applications of ancillary testing, and alternative points of view. This special issue of Human Pathology uniquely unites evidence-based medicine, where appropriate, with the collective personal experiences of a wide range of accomplished pathologists from varying institutions and backgrounds, addressing problematic areas, updated and sometimes imperfect classification systems, and their personal preferences for cost-effectively incorporating ancillary testing...
March 29, 2024: Human Pathology
#20
JOURNAL ARTICLE
Kaiyu Shen, Liu Yang, Shuaiyi Ke, Wencang Gao
BACKGROUND: Bone malignancies (BM), including osteosarcoma, Ewing's sarcoma, chondrosarcoma, and chordoma, are characterized by high rates of recurrence and mortality, despite the availability of diverse treatment approaches. Immunotherapy has gained increasing importance in cancer treatment. However, there is a lack of comprehensive studies that utilize bibliometric analysis to explore immunotherapy for BM. METHODS: A literature search of English studies on BM and immunotherapy from 2010 to 2023 was conducted in the Web of Science Core Collection database...
March 29, 2024: Medicine (Baltimore)
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