Yiwa Pan, Junyao Yang, Yongzhen Wei, He Wang, Rongkuan Jiao, Ana Moraga, Zhongyi Zhang, Yanhua Hu, Deling Kong, Qingbo Xu, Lingfang Zeng, Qiang Zhao
Cardiovascular disease is a leading cause of morbidity and mortality globally. Accumulating evidence indicates that local resident stem/progenitor cells play an important role in vascular regeneration. Recently, it is demonstrated that a histone deacetylase 7-derived 7-amino acid peptide (7A, MHSPGAD) is critical in modulating the mobilization and orientated differentiation of these stem/progenitor cells. Here, its therapeutic efficacy in vascular repair and regeneration is evaluated. In vitro functional analyses reveal that the 7A peptide, in particular phosphorylated 7A (7Ap, MH[pSer]PGAD), could increase stem cell antigen-1 positive (Sca1+ ) vascular progenitor cell (VPC) migration and differentiation toward an endothelial cell lineage...
August 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)