Carolina García-Poyatos, Prateek Arora, Enrique Calvo, Ines J Marques, Nick Kirschke, Maria Galardi-Castilla, Carla Lembke, Marco Meer, Paula Fernández-Montes, Alexander Ernst, David Haberthür, Ruslan Hlushchuk, Jesús Vázquez, Peter Vermathen, José Antonio Enríquez, Nadia Mercader
The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV2 formation, metabolic alterations, and non-pathological muscle performance decline...
May 2, 2024: Developmental Cell