Barbara Nunes Padovani, Camila Morales Fénero, Lais Cavalieri Paredes, Mariana Abrantes do Amaral, Omar Domínguez-Amorocho, Marcella Cipelli, Juliana Moreira Mendonça Gomes, Eloisa Martins da Silva, Luísa Menezes Silva, Raquel de Souza Vieira, Mariana Tominaga Pereira, Mario Costa Cruz, Niels Olsen Saraiva Câmara
Cisplatin is an antineoplastic agent used to treat various tumors. In mammals, it can cause nephrotoxicity, tissue damage, and inflammation. The release of inflammatory mediators leads to the recruitment and infiltration of immune cells, particularly neutrophils, at the site of inflammation. Cisplatin is often used as an inducer of acute kidney injury (AKI) in experimental models, including zebrafish ( Danio rerio ), due to its accumulation in kidney cells. Current protocols in larval zebrafish focus on studying its effect as an AKI inducer but ignore other systematic outcomes...
February 17, 2024: International Journal of Molecular Sciences