Flora A McClure, Kelly Wemyss, Joshua R Cox, Hayley M Bridgeman, Ian E Prise, James I King, Shafqat Jaigirdar, Annie Whelan, Gareth W Jones, John R Grainger, Matthew R Hepworth, Joanne E Konkel
Th17 cell plasticity is crucial for development of autoinflammatory disease pathology. Periodontitis is a prevalent inflammatory disease where Th17 cells mediate key pathological roles, yet whether they exhibit any functional plasticity remains unexplored. We found that during periodontitis, gingival IL-17 fate-mapped T cells still predominantly produce IL-17A, with little diversification of cytokine production. However, plasticity of IL-17 fate-mapped cells did occur during periodontitis, but in the gingiva draining lymph node...
August 5, 2024: Journal of Experimental Medicine