Ioanna Liatsou, Yingli Fu, Zhi Li, Mahmud Hasan, Xin Guo, Jing Yu, Joseph Piccolo, Allison Cartee, Hao Wang, Yong Du, Jeffrey Bryan, Kathleen Gabrielson, Dara L Kraitchman, George Sgouros
PURPOSE: Current treatments for osteosarcoma (OS) have a poor prognosis, particularly for patients with metastasis and recurrence, underscoring an urgent need for new targeted therapies to improve survival. Targeted alpha-particle therapy selectively delivers cytotoxic payloads to tumors with radiolabeled molecules that recognize tumor-associated antigens. We have recently demonstrated the potential of an FDA approved, humanized anti-GD2 antibody, hu3F8, as a targeted delivery vector for radiopharmaceutical imaging of OS...
December 18, 2023: European Journal of Nuclear Medicine and Molecular Imaging