Daniel Antunes Moreno, Murilo Bonatelli, Augusto Perazzolo Antoniazzi, Flávia Escremim de Paula, Leticia Ferro Leal, Felipe Antônio de Oliveira Garcia, André Escremim de Paula, Gustavo Ramos Teixeira, Iara Viana Vidigal Santana, Fabiano Saggioro, Luciano Neder, Elvis Terci Valera, Carlos Alberto Scrideli, João Stavale, Suzana Maria Fleury Malheiros, Matheus Lima, Glaucia Noeli Maroso Hajj, Hernan Garcia-Rivello, Silvia Christiansen, Susana Nunes, Maria João Gil-da-Costa, Jorge Pinheiro, Flavia Delgado Martins, Carlos Almeida Junior, Bruna Minniti Mançano, Rui Manuel Reis
PURPOSE: Medulloblastomas are the most common primary malignant brain tumors in children. They are divided into molecular subgroups: WNT-activated, SHH-Activated, TP53 mutant or wild type, and non-WNT/non-SHH (Groups 3 and 4). WNT-activated medulloblastomas are usually caused by mutations in the CTNNB1 gene (85%-90%), and most remaining cases of CTNNB1 wild type are thought to be caused by germline mutations in APC . So far, the frequencies of CTNNB1 have been reported mainly in North American and European populations...
2023: Frontiers in Oncology