Yael Kusne, Atefeh Ghorbanzadeh, Alina Dulau-Florea, Ruba Shalhoub, Pedro E Alcedo, Khanh Nghiem, Marcela A Ferrada, Alexander Hines, Kaitlin A Quinn, Sumith R Panicker, Amanda K Ombrello, Kaaren Reichard, Ivana Darden, Wendy Goodspeed, Jibran Durrani, Lorena Wilson, Horatiu Olteanu, Terra Lasho, Daniel L Kastner, Kenneth J Warrington, Abhishek Mangaonkar, Ronald S Go, Raul C Braylan, David B Beck, Mrinal M Patnaik, Neal S Young, Katherine R Calvo, Ana I Casanegra, Peter C Grayson, Matthew J Koster, Colin O Wu, Yogendra Kanthi, Bhavisha A Patel, Damon E Houghton, Emma M Groarke
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome, caused by somatic mutations in UBA1, is an autoinflammatory disorder with diverse systemic manifestations. Thrombosis is a prominent clinical feature of VEXAS syndrome. The risk factors and frequency of thrombosis in VEXAS syndrome are not well described, due to the disease's recent discovery and the paucity of large databases. We evaluated 119 patients with VEXAS syndrome for venous and arterial thrombosis and correlated their presence with clinical outcomes and survival...
May 23, 2024: Blood