Evan L Barrios, Jaimar C Rincon, Micah Willis, Valerie E Polcz, John Leary, Dijoia B Darden, Jeremy A Balch, Shawn D Larson, Tyler J Loftus, Alicia M Mohr, Shannon Wallet, Maigan A Brusko, Leandro Balzano-Nogueira, Guoshuai Cai, Ashish Sharma, Gilbert R Upchurch, Michael P Kladde, Clayton E Mathews, Robert Maile, Lyle L Moldawer, Rhonda Bacher, Philip A Efron
Post-sepsis early mortality is being replaced by survivors who experience either a rapid recovery and favorable hospital discharge or the development of chronic critical illness (CCI) with suboptimal outcomes. The underlying immunological response that determines these clinical trajectories remains poorly defined at the transcriptomic level. As classical and non-classical monocytes are key leukocytes in both the innate and adaptive immune systems, we sought to delineate the transcriptomic response of these cell types...
May 2, 2024: Shock