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JOURNAL ARTICLE
Peige Song, Jing Wu, Jin Cao, Weidi Sun, Xiaoyu Li, Tianjing Zhou, Yaojia Shen, Xiao Tan, Xinxin Ye, Changzheng Yuan, Yajie Zhu, Igor Rudan
BACKGROUND: Restless legs syndrome (RLS) is a prevalent neuro-sensory disorder that impairs quality of life. In this systematic review and modelling study, we estimated the global and regional prevalence of RLS and its associated factors. METHODS: We searched PubMed, Embase, and Medline for population-based studies on RLS prevalence published up to 12 November 2023. The included studies reported prevalence using the International Restless Leg Syndrome Study Group's (IRLSSG) minimal diagnostic criteria without limitations on frequency, duration, or severity...
June 7, 2024: Journal of Global Health
#2
JOURNAL ARTICLE
Mary Angeline Luz Ubias Hernandez, Kevin Ivan Peñaverde Chan, Kathleen Joy O Khu
BACKGROUND: External ventricular drain (EVD) insertion is a common neurosurgical procedure used to treat acute hydrocephalus. In this report, we present a rare case of an EVD that was initially correctly placed within the frontal horn but subsequently migrated to the cisterna magna, the first to be reported in the literature. CASE DESCRIPTION: A 46-year-old man with postoperative meningitis and hydrocephalus underwent EVD insertion using an improvised EVD system...
2024: Surgical Neurology International
#3
JOURNAL ARTICLE
Barbara Schormair, Chen Zhao, Steven Bell, Maria Didriksen, Muhammad S Nawaz, Nathalie Schandra, Ambra Stefani, Birgit Högl, Yves Dauvilliers, Cornelius G Bachmann, David Kemlink, Karel Sonka, Walter Paulus, Claudia Trenkwalder, Wolfgang H Oertel, Magdolna Hornyak, Maris Teder-Laving, Andres Metspalu, Georgios M Hadjigeorgiou, Olli Polo, Ingo Fietze, Owen A Ross, Zbigniew K Wszolek, Abubaker Ibrahim, Melanie Bergmann, Volker Kittke, Philip Harrer, Joseph Dowsett, Sofiene Chenini, Sisse Rye Ostrowski, Erik Sørensen, Christian Erikstrup, Ole B Pedersen, Mie Topholm Bruun, Kaspar R Nielsen, Adam S Butterworth, Nicole Soranzo, Willem H Ouwehand, David J Roberts, John Danesh, Brendan Burchell, Nicholas A Furlotte, Priyanka Nandakumar, Christopher J Earley, William G Ondo, Lan Xiong, Alex Desautels, Markus Perola, Pavel Vodicka, Christian Dina, Monika Stoll, Andre Franke, Wolfgang Lieb, Alexandre F R Stewart, Svati H Shah, Christian Gieger, Annette Peters, David B Rye, Guy A Rouleau, Klaus Berger, Hreinn Stefansson, Henrik Ullum, Kari Stefansson, David A Hinds, Emanuele Di Angelantonio, Konrad Oexle, Juliane Winkelmann
Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy, we performed meta-analyses of genome-wide association studies in 116,647 individuals with RLS (cases) and 1,546,466 controls of European ancestry. The pooled analysis increased the number of risk loci eightfold to 164, including three on chromosome X. Sex-specific meta-analyses revealed largely overlapping genetic predispositions of the sexes (rg = 0...
June 5, 2024: Nature Genetics
#4
JOURNAL ARTICLE
Wen-Cheng Li, Ya-Chu Hsieh, Pei-Ting Chen, Chia-Ning Lee, Tsung-Yu Tsai
This case report describes an exceptionally rare case in which a prior diagnosis of schizophrenia was later determined to be early-onset Fahr's disease, linked to a genetic mutation in the SLC20A2 gene. Initially, the patient exhibited symptoms resembling schizophrenia, including aggression and hostility, and was highly susceptible to medication side effects such as restlessness and Parkinsonism. Despite maintaining independent activities of daily living, his neurological examinations revealed hidden weakness on the left side...
2024: Frontiers in Psychiatry
#5
Seyedehnasibeh Sadati, Forouzan Elyasi, Zahra Shyasi, Behzad Rouhanizadeh
BACKGROUND: Neuroleptic malignant syndrome (NMS) is a rare and potentially life-threatening condition that may arise at any point during treatment and is often associated with adverse reactions to dopamine-blocking agents. This syndrome is normally characterized by features such as muscle rigidity, alteration in consciousness, autonomic instability, and leukocytosis. AIM: The aim of this study is to investigate a borderline intellectual functioning (BIF) case in which NMS with insidious disease progression and long prodromal symptoms was developed...
June 4, 2024: Neuropsychopharmacology Reports
#6
JOURNAL ARTICLE
Isao Ohsawa, Akiko Onuki, Fumie Oka, Yoshiyuki Matsuoka, Yuko Makita, Takashi Kobayashi, Yasuhiko Kanaguchi, Yuya Nakamura, Yusuke Suzuki, Yoshikazu Goto, Hiromichi Gotoh
BACKGROUND: Long-term enzyme replacement therapy (ERT) may improve prognosis in the patients with Fabry disease (FD), however, detail psychosocial burden has not been focused on long life expectancy. We experienced a male case of FD under ERT, he was placed on hemodialysis and presented rapidly progressive cognitive function. CASE PRESENTATION: A 51-year-old male patient with FD has been receiving ERT from age of 38 years. Hemodialysis was initiated at the age of 47 years...
June 3, 2024: BMC Nephrology
#7
JOURNAL ARTICLE
Bowen Zhou, Wei Li, Yajun Li, Dongkai Sun, Xin Du
OBJECTIVE: To investigate the effect of self-developed Ye'an Analgetic Decoction/Jiawei Shaoyao Gancao Decoction on Traditional Chinese Medicine (TCM) symptom scores and RLS Severity of patients with restless legs syndrome (RLS). METHODS: This was a clinical comparative study. Eighty patients with RLS admitted to Baoding No.1 Central Hospital from January 2022 to December 2022 were randomly divided into observation group and control group(n=40). Patients in the control group were given basic and oral tramadol treatment, while those in the observation group were given self-developed Ye'an Analgetic Decoction/Jiawei Shaoyao Gancao Decoction based on the treatment in the control group...
2024: Pakistan Journal of Medical Sciences Quarterly
#8
JOURNAL ARTICLE
Elena Martinez-Cayuelas, Beatriz Moreno-Vinués, Isabel Pérez-Sebastián, Teresa Gavela-Pérez, Genoveva Del Rio-Camacho, Carmen Garcés, Leandro Soriano-Guillén
Sleep problems are common in autism spectrum disorder (ASD) and different factors can contribute to its occurrence in this population. Misalignment of the biological clock (our circadian system) has been described as one possible explanation. While there is a body of research on sleep problems, relatively less is known about circadian functioning and the specific population of autistic children with co-occurring attention deficit hyperactivity disorder (ADHD). Using an ambulatory circadian monitoring (ACM) system, which resembles a common watch, we gathered sleep parameters and the different rhythms obtained from measuring motor activity, light exposure and distal temperature in 87 autistic children and adolescents, 27 of whom were diagnosed with co-occurring ADHD, and 30 neurotypical children and adolescents as a comparison group...
May 30, 2024: Autism: the International Journal of Research and Practice
#9
JOURNAL ARTICLE
Jeffrey H Meyer, ZhaoHui Wang, Apitharani Santhirakumar, Yekta Dowlati, Natalia Docteur, Aqsa Shoaib, Jareeat Purnava, Yanqi Wang, Wei Wang, Sheng Chen, Muhammad I Husain, Rashmi de Silva Wijeyeratne, Heba Reeyaz, Catalina Baena-Tan, Yuko Koshimori, Zahra Nasser, Valery Sit
BACKGROUND: Postpartum blues (PPB) is a frequent syndrome of sad mood, crying spells, anxiety, restlessness, reduced appetite, and irritability, typically peaking day 5 postpartum. When severe, it greatly increases risk for later postpartum depression. This trial compared a dietary supplement to placebo on PPB severity. The supplement was designed to counter downstream effects of elevated monoamine oxidase A level, implicated in causing PPB. METHODS: Participants recruited by advertisement from the Toronto region completed procedures at CAMH, Canada and/or participants' homes...
May 2024: EClinicalMedicine
#10
REVIEW
Şengül Kocamer Şahin, Esra Aslan
The feeling of emotional tension, restlessness, pressure, and inability to relax is referred to as psychological stress. Although it is unclear how psychological stress affects neurobiological processes, several factors are thought to be involved, including central and peripheral neuroinflammation, structural degeneration in the prefrontal cortex and hippocampus, alterations in fear neurocircuitry, and neuroplasticity. Aside from data relating cognitive impairment to chronic low-grade inflammatory stress, there is growing evidence linking mental stress, oxidative stress, and systemic inflammation to the development of psychological disorders...
May 15, 2024: Journal of Integrative Neuroscience
#11
JOURNAL ARTICLE
Jirada Sringean
PURPOSE OF REVIEW: This review aimed to comprehensively outline sleep and circadian rhythm abnormalities in hyperkinetic movement disorders beyond Parkinson's disease and atypical parkinsonisms, including tremor, dystonia, choreiform movements, tics, and ataxia disorders. RECENT FINDINGS: Insomnia, poor sleep quality, and excessive daytime sleepiness (EDS) are commonly reported in essential tremor, Wilson's disease, tics or Tourette's syndrome, and spinocerebellar ataxia (SCA)...
May 30, 2024: Current Opinion in Neurology
#12
RANDOMIZED CONTROLLED TRIAL
Danielle R Payne, Jaime Vinson, Jan Powers, Brandon T McDaniel, Cherise Sevier, Cynthia Marshall, Sue Sell
Perioperative anxiety is common in surgical patients and linked to poor outcomes. This multicenter randomized controlled trial assessed the effect of the use of a warm weighted blanket on presurgical anxiety and pain, as well as postsurgical restlessness, nausea, and vomiting. Levels of anxiety and pain were measured in adult patients using a 100-point visual analog scale before elective surgery. Patients received either a warm weighted blanket (n = 74) or a traditional sheet or nonweighted blanket (n = 74)...
June 2024: AORN Journal
#13
JOURNAL ARTICLE
Chen-Sen Ouyang, Rei-Cheng Yang, Rong-Ching Wu, Ching-Tai Chiang, Yi-Hung Chiu, Lung-Chang Lin
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is diagnosed in accordance with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria by using subjective observations and information provided by parents and teachers. However, subjective analysis often leads to overdiagnosis or underdiagnosis. There are two types of motor abnormalities in patients with ADHD. First, hyperactivity with fidgeting and restlessness is the major diagnostic criterium for ADHD...
May 27, 2024: Child and Adolescent Psychiatry and Mental Health
#14
Maneesha Lingarapu, Bisma Shaikh, Ajeet Singh, Mustafa Ahmed Khan, Malik Olatunde Oduoye, Nancy Kamboj, Mahmood Danishwar
KEY CLINICAL MESSAGE: Immunosuppression from B-acute lymphoblastic leukemia (B-ALL) chemotherapy and a preceding COVID-19 infection may predispose patients to rare complications such as rhino-orbital mucormycosis. Hence, a high index of suspicion should be maintained by physicians (and oncologists) if patients undergoing B-ALL treatment present with orofacial symptoms and ophthalmological manifestations such as peri-orbital swelling, ophthalmoplegia, and loss of vision, suggestive of infection...
June 2024: Clinical Case Reports
#15
REVIEW
Chiara Voltan, Francesca Concer, Luca Pecoraro, Angelo Pietrobelli, Giorgio Piacentini, Marco Zaffanello
This narrative review study investigates the correlations between obesity, allergies, and sleep-disordered breathing in pediatric populations. Searches for pertinent articles were conducted on the Medline PubMed Advanced Search Builder, Scopus, and Web of Science databases from unlimited to April 2024. Sleep-disordered breathing causes repeated upper airway obstructions, leading to apneas and restless sleep. Childhood obesity, which affects around 20% of children, is often associated with sleep-disordered breathing and allergies such as asthma and allergic rhinitis...
May 15, 2024: Children
#16
REVIEW
Owen D Lyons
Sleep disorders are highly prevalent in chronic kidney disease (CKD) but are often under-recognized. Restless legs syndrome, which is common in CKD owing to issues with dopamine metabolism and is exacerbated by iron deficiency and uraemia, can lead to poor sleep quality and increased daytime fatigue. Insomnia is also prevalent in CKD, particularly in patients requiring dialysis, with increased sleep latency and sleep fragmentation being reported. The cause of insomnia in CKD is multifactorial - poor sleep habits and frequent napping during dialysis, uraemia, medications and mood disorders have all been suggested as potential contributing factors...
May 24, 2024: Nature Reviews. Nephrology
#17
JOURNAL ARTICLE
Jongsook Rhee, Ilchung Shin, Jihyun Kim, Juseun Lee, Byungsuk Cho, Junghyun Kim, Meejung Park, Eunmi Kim
Kratom is a natural psychoactive product known primarily in Southeast Asia, including Thailand, Malaysia etc. It is also known as krathom, kakuam, ithang, thom (Thailand), biak-biak, ketum (Malaysia) and mambog (Philippines), and is sometimes used as an opium substitute. It is stimulant at doses of 1-5g, analgesic at doses of 5-15g, and euphoric and sedative at doses above 15g. Mitragynine is the most abundant indole compound in kratom (Mitragyna speciosa) and is metabolized in humans to 7-hydroxymitragynine, the more active metabolite...
May 23, 2024: Journal of Analytical Toxicology
#18
JOURNAL ARTICLE
Guoqiang Xiao, Hongting Shi, Qiaoyu Lan, Jiajia Hu, Jincheng Guan, Zhuoji Liang, Chumeng Zhou, Zitong Huang, Yongyuan Chen, Borong Zhou
BACKGROUND: Epidemiological evidence indicates a high correlation and comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and Restless Legs Syndrome (RLS). OBJECTIVE: We aimed to investigate the causal relationship and shared genetic architecture between ADHD and RLS, as well as explore potential causal associations between both disorders and peripheral iron status. METHODS: We performed two-sample Mendelian randomization (MR) analyses using summary statistics from genome-wide meta-analyses of ADHD, RLS, and peripheral iron status (serum iron, ferritin, transferrin saturation, and total iron binding capacity)...
2024: Frontiers in Psychiatry
#19
JOURNAL ARTICLE
Shirley Cohen-Mekelburg, Cathy A Goldstein, Muneer Rizvydeen, Zainab Fayyaz, Priya J Patel, Jeffrey A Berinstein, Shrinivas Bishu, Kelly C Cushing-Damm, Hyungjin Myra Kim, Helen J Burgess
BACKGROUND: Inflammatory bowel disease (IBD) affects over 3 million Americans and has a relapsing and remitting course with up to 30% of patients experiencing exacerbations each year despite the availability of immune targeted therapies. An urgent need exists to develop adjunctive treatment approaches to better manage IBD symptoms and disease activity. Circadian disruption is associated with increased disease activity and may be an important modifiable treatment target for IBD. Morning light treatment, which advances and stabilizes circadian timing, may have the potential to improve IBD symptoms and disease activity, but no studies have explored these potential therapeutic benefits in IBD...
May 22, 2024: BMC Gastroenterology
#20
Jacey Bedford
No abstract text is available yet for this article.
May 22, 2024: Nature
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