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JOURNAL ARTICLE
Sabina Farhadova, Amani Ghousein, François Charon, Caroline Surcis, Melisa Gomez-Velazques, Clara Roidor, Flavio Di Michele, Maud Borensztein, Albertina De Sario, Cyril Esnault, Daan Noordermeer, Benoit Moindrot, Robert Feil
The imprinted Dlk1-Dio3 domain comprises the developmental genes Dlk1 and Rtl1, which are silenced on the maternal chromosome in different cell types. On this parental chromosome, the domain's imprinting control region activates a polycistron that produces the lncRNA Meg3 and many miRNAs (Mirg) and C/D-box snoRNAs (Rian). Although Meg3 lncRNA is nuclear and associates with the maternal chromosome, it is unknown whether it controls gene repression in cis. We created mouse embryonic stem cells (mESCs) that carry an ectopic poly(A) signal, reducing RNA levels along the polycistron, and generated Rian-/- mESCs as well...
April 13, 2024: Nucleic Acids Research
#2
JOURNAL ARTICLE
Nicoline Potgieter, Viviane Pereira, Roberto Elias, Senda Charone, Sonia Groisman
INTRODUCTION: Providing conventional, restorative dental care to children with special healthcare needs (CSHCN) often requires sedation using general anesthesia. Saliva consistency, diet, and oral hygiene practice are different for CSHCN, and limited evidence is available on the efficacy of silver fluoride (SF) for the management of carious lesions for this vulnerable population. METHODS: Parents of CSHCN were educated about silver fluoride as a treatment option for caries...
2024: Front Oral Health
#3
JOURNAL ARTICLE
Camille Guillemin, Nora Vandeleene, Maëlle Charonitis, Florence Requier, Gaël Delrue, Emilie Lommers, Pierre Maquet, Christophe Phillips, Fabienne Collette
Cognitive fatigue is a major symptom of Multiple Sclerosis (MS), from the early stages of the disease. This study aims to detect if brain microstructure is altered early in the disease course and is associated with cognitive fatigue in people with MS (pwMS) compared to matched healthy controls (HC). Recently diagnosed pwMS (N = 18, age < 45 years old) with either a Relapsing-Remitting or a Clinically Isolated Syndrome course of the disease, and HC (N = 19) matched for sex, age and education were analyzed...
March 28, 2024: Journal of Neurology
#4
JOURNAL ARTICLE
Justine Gantzer, Maud Toulmonde, François Severac, Ali N Chamseddine, Céline Charon-Barra, Charles Vinson, Alice Hervieu, Agathe Bourgmayer, François Bertucci, Thomas Ryckewaert, Thibaud Valentin, Nelly Firmin, Loïc Chaigneau, Emmanuelle Bompas, Philippe Follana, Nathalie Rioux-Leclercq, Pauline Soibinet-Oudot, Laurence Bozec, François Le Loarer, Noëlle Weingertner, Christine Chevreau, Florence Duffaud, Jean-Yves Blay, Jean-Emmanuel Kurtz, Patrick Schöffski, Mehdi Brahmi, Gabriel G Malouf
BACKGROUND: Perivascular epithelioid cell neoplasms (PEComas) encompass a heterogeneous family of mesenchymal tumors. Previously described clinicopathologic features aimed at distinguishing benign from malignant variants but lacked prognostic value. METHODS: This retrospective analysis examined clinicopathologic data from patients who had localized PEComa across French Sarcoma Network centers. The authors analyzed 12 clinicopathologic features in a Cox proportional hazard framework to derive a multivariate prognostic risk model for event-free survival (EFS)...
March 12, 2024: Cancer
#5
REVIEW
Alessandra Scaravilli, Mario Tranfa, Giuseppe Pontillo, Bernard Brais, Giovanna De Michele, Roberta La Piana, Francesco Saccà, Filippo Maria Santorelli, Matthis Synofzik, Arturo Brunetti, Sirio Cocozza
The complexity in diagnosing hereditary degenerative ataxias lies not only in their rarity, but also in the variety of different genetic conditions that can determine sometimes similar and overlapping clinical findings. In this light, Magnetic Resonance Imaging (MRI) plays a key role in the evaluation of these conditions, being a fundamental diagnostic tool needed not only to exclude other causes determining the observed clinical phenotype, but also to proper guide to an adequate genetic testing. Here, we propose an MRI-based diagnostic algorithm named CHARON (Characterization of Hereditary Ataxias Relying On Neuroimaging), to help in disentangling among the numerous, and apparently very similar, hereditary degenerative ataxias...
March 4, 2024: Cerebellum
#6
JOURNAL ARTICLE
Clara Charon, Pierre-Henri Wuillemin, Charlotte Havreng-Théry, Joël Belmin
OBJECTIVES: Pressure ulcers (PUs) are a common and avoidable condition among residents of nursing homes, and their consequences are severe. Reliable and simple identification of high-risk residents is a major challenge for prevention. Available tools like the Braden and Norton scale have imperfect predictive performance. The objective is to predict the occurrence of PUs in nursing home residents from electronic health record (EHR) data. DESIGN: Longitudinal retrospective nested case-control study...
February 28, 2024: Journal of the American Medical Directors Association
#7
JOURNAL ARTICLE
S Brosseau, P Abreu, C Bouchez, L Charon, Y Kieffer, G Gentric, V Picant, I Veith, J Camonis, S Descroix, F Mechta-Grigoriou, M C Parrini, G Zalcman
The Yes-associated protein (YAP) oncoprotein has been linked to both metastases and resistance to targeted therapy of lung cancer cells. We aimed to investigate the effect of YAP pharmacological inhibition, using YAP/TEA domain (TEAD) transcription factor interaction inhibitors in chemo-resistant lung cancer cells. YAP subcellular localization, as a readout for YAP activation, cell migration, and TEAD transcription factor functional transcriptional activity were investigated in cancer cell lines with up-regulated YAP, with and without YAP/TEAD interaction inhibitors...
March 1, 2024: Molecular and Cellular Biochemistry
#8
JOURNAL ARTICLE
Natasja Charon Wouda, Brenda Knijff, Michiel Punt, Johanna Maria Augusta Visser-Meily, Martijn Frits Pisters
Patients recovering from a stroke experience reduced participation, especially when they are limited in daily activities involving walking. Understanding the recovery of independent walking, can be used by clinicians in the decision-making process during rehabilitation, resulting in more personalized stroke rehabilitation. Therefore, it is necessary to gain insight in predicting the recovery of independent walking in patients after stroke. This systematic review provided an overview of current evidence about prognostic models and its performance to predict recovery of independent walking after stroke...
May 1, 2024: American Journal of Physical Medicine & Rehabilitation
#9
JOURNAL ARTICLE
Soledad Traubenik, Céline Charon, Thomas Blein
As sessile organisms, plants are continuously exposed to heterogeneous and changing environments and constantly need to adapt their growth strategies. They have evolved complex mechanisms to recognize various stress factors, activate appropriate signaling pathways, and respond accordingly by reprogramming the expression of multiple genes at the transcriptional, post-transcriptional, and even epigenome levels to tolerate stressful conditions such as drought, high temperature, nutrient deficiency, and pathogenic interactions...
January 21, 2024: Plant Physiology
#10
JOURNAL ARTICLE
Michael J Lynch, Maithili Deshpande, Kurni Kurniyati, Kai Zhang, Milinda James, Michael Miller, Sheng Zhang, Felipe J Passalia, Elsio A Wunder, Nyles W Charon, Chunhao Li, Brian R Crane
Spirochetes cause Lyme disease, leptospirosis, syphilis, and several other human illnesses. Unlike other bacteria, spirochete flagella are enclosed within the periplasmic space where the filaments distort and push the cell body by the action of the flagellar motors. We previously demonstrated that the oral pathogen Treponema denticola (Td) and Lyme disease pathogen Borreliella burgdorferi (Bb) form covalent lysinoalanine (Lal) cross-links between conserved cysteine and lysine residues of the FlgE protein that composes the flagellar hook...
December 2023: PNAS Nexus
#11
JOURNAL ARTICLE
Lucie Charon, Claire Launois, Jeanne-Marie Perotin, Bruno Ravoninjatovo, Pauline Mulette, Julien Ancel, Thomas Guillard, Anaëlle Muggeo, Valérian Dormoy, Muriel Griffon, Sophie Carré, François Lebargy, Gaëtan Deslée, Sandra Dury
BACKGROUND: Cough and sputum are major symptoms in cystic fibrosis (CF) that contribute to the impairment of quality of life. METHODS: This prospective single centre cross-sectional pilot study aimed to evaluate the results of a self-administered questionnaire assessing cough and sputum symptoms (2 domains), and their impact (2 domains) on daily activities in the previous week, named the Cough and Sputum Assessment Questionnaire (CASA-Q) in CF adult patients at stable state, and to analyse associations with clinical, functional, microbiological, radiological data, and two quality of life scales: the Cystic Fibrosis Questionnaire Revised (CFQ-R) and the Saint George Respiratory Questionnaire (SGRQ)...
November 21, 2023: BMC Pulmonary Medicine
#12
JOURNAL ARTICLE
Wave-scattering processes: path-integrals designed for the numerical handling of complex geometries.
Jérémi Dauchet, Julien Charon, Stéphane Blanco, Laurent Brunel, Jean-François Cornet, Christophe Coustet, Mouna El Hafi, Vincent Eymet, Vincent Forest, Richard Fournier, Fabrice Gros, Benjamin Piaud, Guillaume Terrée, Thomas Vourc'h
Relying on Feynman-Kac path-integral methodology, we present a new statistical perspective on wave single-scattering by complex three-dimensional objects. The approach is implemented on three models-Schiff approximation, Born approximation, and rigorous Born series-and familiar interpretative difficulties such as the analysis of moments over scatterer distributions (size, orientation, shape, etc.) are addressed. In terms of the computational contribution, we show that commonly recognized features of the Monte Carlo method with respect to geometric complexity can now be available when solving electromagnetic scattering...
September 15, 2023: Optics Letters
#13
JOURNAL ARTICLE
Roelof van Ewijk, Cyrano Chatziantoniou, Madeleine Adams, Patrizia Bertolini, Gianni Bisogno, Amine Bouhamama, Pablo Caro-Dominguez, Valerie Charon, Ana Coma, Rana Dandis, Christine Devalck, Giulia De Donno, Andrea Ferrari, Marta Fiocco, Soledad Gallego, Chiara Giraudo, Heidi Glosli, Simone A J Ter Horst, Meriel Jenney, Willemijn M Klein, Alexander Leemans, Julie Leseur, Henry C Mandeville, Kieran McHugh, Johannes H M Merks, Veronique Minard-Colin, Salma Moalla, Carlo Morosi, Daniel Orbach, Lil-Sofie Ording Muller, Erika Pace, Pier Luigi Di Paolo, Katia Perruccio, Lucia Quaglietta, Marleen Renard, Rick R van Rijn, Antonio Ruggiero, Sara I Sirvent, Alberto De Luca, Reineke A Schoot
OBJECTIVE: To investigate the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) as a predictive imaging marker after neoadjuvant chemotherapy in patients with rhabdomyosarcoma. MATERIAL AND METHODS: We performed a multicenter retrospective study including pediatric, adolescent and young adult patients with rhabdomyosarcoma, Intergroup Rhabdomyosarcoma Study group III/IV, treated according to the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 or MTS2008 studies...
September 8, 2023: Pediatric Radiology
#14
Michael J Lynch, Maithili Deshpande, Kurni Kyrniyati, Kai Zhang, Milinda James, Michael Miller, Sheng Zhang, Felipe J Passalia, Elsio A Wunder, Nyles W Charon, Chunhao Li, Brian R Crane
UNLABELLED: Spirochete bacteria cause Lyme disease, leptospirosis, syphilis and several other human illnesses. Unlike other bacteria, spirochete flagella are enclosed within the periplasmic space where the filaments distort and push the cell body by action of the flagellar motors. We previously demonstrated that the oral pathogen Treponema denticola (Td) catalyzes the formation of covalent lysinoalanine (Lal) crosslinks between conserved cysteine and lysine residues of the FlgE protein that composes the flagellar hook...
June 13, 2023: bioRxiv
#15
REVIEW
Elisabeth Guthrie, Rita Charon
Despite decades of international entreaties for improvement, education about and provision of healthcare for people with disabilities remains harmfully inferior to that of the non-disabled population. Many obstacles confound efforts to ameliorate this inequity, perhaps the most pernicious of which is negative bias on the part of providers. Narrative medicine offers a means to address healthcare attitudes towards people with disabilities, in particular negative attitudes based on 'ableism'. Through absorbing, writing, and sharing of diverse perspectives, narrative medicine kindles imagination and empathy, promoting self-reflection...
June 30, 2023: Developmental Medicine and Child Neurology
#16
JOURNAL ARTICLE
Clara Charon, Pierre-Henri Wuillemin, Joël Belmin
An automated ML classifier predicting pressure ulcers one-month before performs better than the reference methods currently used in nursing homes.
May 18, 2023: Studies in Health Technology and Informatics
#17
JOURNAL ARTICLE
Anthony Bergeron, Aurélie Bertaut, Françoise Beltjens, Céline Charon-Barra, Alix Amet, Clémentine Jankowski, Isabelle Desmoulins, Sylvain Ladoire, Laurent Arnould
BACKGROUND: HER2 expression is often negative or low in primary breast cancers (BCs) but its changes with disease progression remain poorly known. We aimed to estimate them between primary and recurrent tumours, and identify predictive factors. METHODS: We compared the HER2 status, and clinical and pathological characteristics by its evolution category (stable or changed), between all primary BCs and matched recurrences registered in our database in 2000-2020 (n = 512)...
July 2023: British Journal of Cancer
#18
JOURNAL ARTICLE
Nora Vandeleene, Camille Guillemin, Solène Dauby, Florence Requier, Maëlle Charonitis, Daphne Chylinski, Evelyne Balteau, Pierre Maquet, Emilie Lommers, Christophe Phillips
INTRODUCTION: Quantitative MRI quantifies tissue microstructural properties and supports the characterization of cerebral tissue damages. With an MPM protocol, 4 parameter maps are constructed: MTsat, PD, R1 and R2*, reflecting tissue physical properties associated with iron and myelin contents. Thus, qMRI is a good candidate for in vivo monitoring of cerebral damage and repair mechanisms related to MS. Here, we used qMRI to investigate the longitudinal microstructural changes in MS brain...
April 20, 2023: Brain and Behavior
#19
JOURNAL ARTICLE
Emmanuel Hartman, Yashil Sukurdeep, Eric Klassen, Nicolas Charon, Martin Bauer
UNLABELLED: This paper introduces a set of numerical methods for Riemannian shape analysis of 3D surfaces within the setting of invariant (elastic) second-order Sobolev metrics. More specifically, we address the computation of geodesics and geodesic distances between parametrized or unparametrized immersed surfaces represented as 3D meshes. Building on this, we develop tools for the statistical shape analysis of sets of surfaces, including methods for estimating Karcher means and performing tangent PCA on shape populations, and for computing parallel transport along paths of surfaces...
2023: International Journal of Computer Vision
#20
JOURNAL ARTICLE
Jean Marc Tregan, Jean Luc Amestoy, Megane Bati, Jean-Jacques Bezian, Stéphane Blanco, Laurent Brunel, Cyril Caliot, Julien Charon, Jean-Francois Cornet, Christophe Coustet, Louis d'Alençon, Jeremi Dauchet, Sebastien Dutour, Simon Eibner, Mouna El Hafi, Vincent Eymet, Olivier Farges, Vincent Forest, Richard Fournier, Mathieu Galtier, Victor Gattepaille, Jacques Gautrais, Zili He, Frédéric Hourdin, Loris Ibarrart, Jean-Louis Joly, Paule Lapeyre, Pascal Lavieille, Marie-Helene Lecureux, Jacques Lluc, Marc Miscevic, Nada Mourtaday, Yaniss Nyffenegger-Péré, Lionel Pelissier, Lea Penazzi, Benjamin Piaud, Clément Rodrigues-Viguier, Gisele Roques, Maxime Roger, Thomas Saez, Guillaume Terrée, Najda Villefranque, Thomas Vourc'h, Daniel Yaacoub
It was recently shown that radiation, conduction and convection can be combined within a single Monte Carlo algorithm and that such an algorithm immediately benefits from state-of-the-art computer-graphics advances when dealing with complex geometries. The theoretical foundations that make this coupling possible are fully exposed for the first time, supporting the intuitive pictures of continuous thermal paths that run through the different physics at work. First, the theoretical frameworks of propagators and Green's functions are used to demonstrate that a coupled model involving different physical phenomena can be probabilized...
2023: PloS One
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