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JOURNAL ARTICLE
Kelsey M Owsley, Romana Hasnain-Wynia, Ronica N Rooks, Gregory J Tung, Glen P Mays, Richard C Lindrooth
IMPORTANCE: The US 340B Drug Pricing Program enables eligible hospitals to receive substantial discounts on outpatient drugs to improve hospitals' financial sustainability and maintain access to care for patients who have low income and/or are uninsured. However, it is unclear whether hospitals use program savings to subsidize access as intended. OBJECTIVE: To evaluate whether the 340B program is associated with improvements in access to hospital-based services and to test whether the association varies by hospital ownership...
May 3, 2024: JAMA health forum
#2
JOURNAL ARTICLE
Şule Özbilgin, Necati Gökmen
For patients monitored in intensive care units in the aftermath of a cardiac arrest, one of the well-established difficulties of care after resuscitation is the ability to perform the necessary prognostic assessments as accurately and early as possible. Although current guidelines include algorithms to determine prognosis, there are still missing links and uncertainties. Biomarkers obtained from peripheral blood are generally non-invasive and easy to obtain. Although the potential to use microRNA as a prognostic biomarker after cardiac arrest has received less interest recently, its popularity has increased in the last few years...
May 3, 2024: Turkish Journal of Anaesthesiology and Reanimation
#3
MULTICENTER STUDY
Lvyuan Shi, Bo Wang, Qin Wu, Jing Yang, Lietao Wang, Dingyuan Wan, Yucong Wang, Zhongxue Feng, Wei Zhang, Li Li, Wenhu Wang, Jun Chen, Xiaohua Ai, Jianwei Zheng, Zhongwei Zhang, Min He
BACKGROUND: An increase in Heatstroke cases occurred in southwest China in 2022 due to factors like global warming, abnormal temperature rise, insufficient power supply, and other contributing factors. This resulted in a notable rise in Heatstroke patients experiencing varying degrees of organ dysfunction. This descriptive study aims to analyze the epidemiology and clinical outcomes of Heatstroke patients in the ICU, providing support for standardized diagnosis and treatment, ultimately enhancing the prognosis of Heatstroke...
2024: Frontiers in Public Health
#4
Alec Gleason, Florian Richter, Nathalia Beller, Naveen Arivazhagan, Rui Feng, Emma Holmes, Benjamin S Glicksberg, Sarah U Morton, Maite La Vega-Talbott, Madeline Fields, Katherine Guttmann, Girish N Nadkarni, Felix Richter
IMPORTANCE: Infant alertness and neurologic changes are assessed by exam, which can be intermittent and subjective. Reliable, continuous methods are needed. OBJECTIVE: We hypothesized that our computer vision method to track movement, pose AI, could predict neurologic changes. DESIGN: Retrospective observational study from 2021-2022. SETTING: A level four urban neonatal intensive care unit (NICU). PARTICIPANTS: Infants with corrected age ≤1 year, comprising 115 patients with 4,705 hours of video data linked to electroencephalograms (EEG), including 46% female and 25...
April 19, 2024: medRxiv
#5
JOURNAL ARTICLE
Jasper David Feldkamp, Joachim Feldkamp
Therapy with thyroid hormones normally is restricted to substitution therapy of patients with primary or secondary hypothyroidism. Typically, thyroid hormones are given orally. There are few indications for intravenous use of thyroid hormones. Indications for parenteral application are insufficient resorption of oral medications due to alterations of the gastrointestinal tract, partial or total loss of consciousness, sedation in the intensive care unit or shock. In almost all cases levothyroxine is the therapy of choice including congenital hypothyroidism...
May 2, 2024: Hormone and Metabolic Research
#6
JOURNAL ARTICLE
Elizabeth Sewell, Susan Cohen, Isabella Zaniletti, Dan Couture, Narendra Dereddy, Carl H Coghill, Tracy M Flanders, Andrew Foy, Gregory G Heuer, Eni Jano, Nicole Kemble, Stephanie Lee, Con Yee Ling, Shadi Malaeb, Ulrike Mietzsch, Eylem Ocal, Michael A Padula, Cherrie D Welch, Bernadette White, Diane Wilson, John Flibotte
OBJECTIVE: To (1) describe differences in types and timing of interventions, (2) report short-term outcomes and (3) describe differences among centres from a large national cohort of preterm infants with post-haemorrhagic hydrocephalus (PHH). DESIGN: Cohort study of the Children's Hospitals Neonatal Database from 2010 to 2022. SETTING: 41 referral neonatal intensive care units (NICUs) in North America. PATIENTS: Infants born before 32 weeks' gestation with PHH defined as acquired hydrocephalus with intraventricular haemorrhage...
May 2, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
#7
JOURNAL ARTICLE
Julian Theuriet, Marion Masingue, Anthony Behin, Ana Ferreiro, Guillaume Bassez, Pauline Jaubert, Oriana Tarabay, Frédéric Fer, Antoine Pegat, Françoise Bouhour, Juliette Svahn, Philippe Petiot, Laurentiu Jomir, Guy Chauplannaz, Catherine Cornut-Chauvinc, Véronique Manel, Emmanuelle Salort-Campana, Shahram Attarian, Etienne Fortanier, Annie Verschueren, Ludivine Kouton, Jean-Philippe Camdessanché, Céline Tard, Armelle Magot, Yann Péréon, Jean-Baptiste Noury, Marie-Christine Minot-Myhie, Maud Perie, Frederic Taithe, Yacine Farhat, Anne-Laure Millet, Pascal Cintas, Guilhem Solé, Marco Spinazzi, Florence Esselin, Dimitri Renard, Sabrina Sacconi, Andra Ezaru, Edoardo Malfatti, Martial Mallaret, Laurent Magy, Eva Diab, Philippe Merle, Maud Michaud, Maxime Fournier, Aleksandra Nadaj Pakleza, Jean-Baptiste Chanson, Claire Lefeuvre, Pascal Laforet, Pascale Richard, Damien Sternberg, Rocio-Nur Villar-Quiles, Tanya Stojkovic, Bruno Eymard
Congenital myasthenic syndromes (CMS) are clinically and genetically heterogeneous diseases caused by mutations affecting neuromuscular transmission. Even if the first symptoms mainly occur during childhood, adult neurologists must confront this challenging diagnosis and manage these patients throughout their adulthood. However, long-term follow-up data from large cohorts of CMS patients are lacking and the long-term prognosis of these patients is largely unknown. We report the clinical features, diagnostic difficulties, and long-term prognosis of a French nationwide cohort of 235 adult patients with genetically confirmed CMS followed in 23 specialized neuromuscular centres...
May 2, 2024: Brain
#8
JOURNAL ARTICLE
Rupesh Chakradhar, Kayleigh Anjali Harrylal, Khusbu Kumari, Susmin Karki, Gopal Sedain, Amit Pradhanang, Sushil K Shilpakar, Mohan Raj Sharma
BACKGROUND: Epidural haematoma (EDH) accounts for up to 15% of severe traumatic brain injury (TBI) cases and remains the most common cause of mortality and disability. Several clinical and radiological factors affect patient outcomes. This study aims to correlate patients' clinical and radiological profiles with acute EDH outcomes. METHODS: A retrospective, single-centred, consecutive case series was conducted on the patients diagnosed with an acute EDH admitted to Tribhuvan University Teaching Hospital (TUTH) between May 2019 and April 2023...
May 2024: Annals of Medicine and Surgery
#9
JOURNAL ARTICLE
Minhye Kim, Younghun Choi, Soo Yeon Kim, Anna Cho, Hunmin Kim, Jong Hee Chae, Ki Joong Kim, Dasom Park, Young Se Kwon, Min-Jee Kim, Mi-Sun Yum, Ju Hyun Kong, Yoon Jin Lee, Byung Chan Lim
BACKGROUND: The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to be more infectious and less severe than the other variants. Despite the increasing number of symptomatic patients, severe neurological complications in children with the Omicron variant have been reported rarely, unlike with wild-type or Delta variants. This study aimed to investigate severe neurological complications in children with Omicron variant infection. METHODS: We conducted a retrospective study of 17 pediatric patients with severe neurological manifestations associated with coronavirus disease 2019 in Korea during the Omicron variant prevalence, from January 1 to April 30, 2022...
April 7, 2024: Pediatric Neurology
#10
JOURNAL ARTICLE
Nolwen Flajoliet, Jeremy Bourenne, Nathalie Marin, Jonathan Chelly, Jean Baptiste Lascarrou, Cédric Daubin, Wulfran Bougouin, Alain Cariou, Guillaume Geri
RATIONALE: About 60 to 70% of out-of-hospital cardiac arrest (OHCA) survivors who worked before cardiac arrest return to work within one year but the precise conditions for this resumption of professional activity remain little known. The objective of this study was to assess components of return to work among OHCA survivors. PATIENTS AND METHODS: We used the French national multicentric cohort AfterRosc to include OHCA survivors admitted between April 1st 2021 and March 31st , discharged alive from the Intensive Care Unit (ICU), and who were less than 65 years old...
April 27, 2024: Resuscitation
#11
REVIEW
Mary Anne J Ryan, Atul Malhotra
Neonatal neurocritical intensive care is dedicated to safeguarding the newborn brain by prioritising clinical practices that promote early identification, diagnosis and treatment of brain injuries. The most common newborn neurological emergency is neonatal seizures, which may also be the initial clinical indication of neurological disease. A high seizure burden in the newborn period independently contributes to increased mortality and morbidity. The majority of seizures in newborns are subclinical (without clinical presentation), and hence identification may be difficult...
April 29, 2024: Pediatric Research
#12
JOURNAL ARTICLE
Ottilie Trocheris-Fumery, Cecilia Scetbon, Thibault Flet, Jonathan Meynier, Magali Sellier, Matthieu Rumbach, Rachid Badaoui, Léonie Villeret, Paul Tarpin, Osama Abou-Arab, Stephane Bar, Herve Dupont
BACKGROUND: Post-induction anaesthesia often promotes intraoperative hypotension (IOH) that can worsen postoperative outcomes. This study aims to assess the benefit of norepinephrine versus ephedrine at the induction of anaesthesia to prevent postoperative complications following major abdominal surgery by preventing IOH. METHODS AND ANALYSIS: The EPON STUDY is a prospective single-centre randomised controlled trial with the planned inclusion of 500 patients scheduled for major abdominal surgery at the Amiens University Hospital...
April 29, 2024: BMJ Open
#13
JOURNAL ARTICLE
Yésica Lamberto, Pablo Saúl, Rosana Gregori-Sabelli, Milagro Sánchez-Cunto, Viviana Chediack, Eleonora Cunto
INTRODUCTION: Meningeal cryptococcosis (MC) is a frequent cause of meningoencephalitis in people living with HIV (PLHIV), leading to substantial morbidity (20-55%). Clinical characteristics, lethality and adverse prognostic factors in PLHIV with MC admitted to intensive care units (ICUs) are described. METHODS: A retrospective observational study. Period from 11/21/2006 to 05/24/2023. It involved 154 adult PLHIV diagnosed with MC and admitted to ICUs. Percentages and absolute values were compared by Chi-Square or Fisher's test and medians by Mann-Whitney test...
2024: Medicina
#14
JOURNAL ARTICLE
Christopher W Mastropietro, Peter Sassalos, Christine M Riley, Kurt Piggott, Kiona Y Allen, Elizabeth Prentice, Raya Safa, Jason R Buckley, David K Werho, Martin Wakeham, Arthur Smerling, Andrew R Yates, Ilias Iliopoulos, Hitesh Sandhu, Saurabh Chiwane, Asaad Beshish, David M Kwiatkowski, Saul Flores, Sukumar Suguna Narashimhulu, Rohit Loomba, Christine A Capone, Francis Pike, John M Costello
OBJECTIVES: Multicenter studies reporting outcomes following tracheostomy in children with congenital heart disease are limited, particularly in patients with single ventricle physiology. We aimed to describe clinical characteristics and outcomes in a multicenter cohort of patients with single ventricle physiology who underwent tracheostomy before Fontan operation. DESIGN: Multicenter retrospective cohort study.SETTING: Twenty-one tertiary care pediatric institutions participating in the Collaborative Research from the Pediatric Cardiac Intensive Care Society...
April 29, 2024: Pediatric Critical Care Medicine
#15
JOURNAL ARTICLE
Patrick T Stewart, Md Bayzidur Rahman, Angela L Chiew, Matt Fitzpatrick, Nicholas J Osborne, Betty S Chan
INTRODUCTION: Patients with sedative overdose may have residual cognitive impairment at the time they are deemed medically cleared for discharge. Impairment could affect the performance of high-risk activities, including driving. The Trail Making Test is an alpha-numeric assessment that can be performed at the bedside to assess cognitive function. We examined whether there were differences in cognitive function when medically cleared between patients that overdosed on sedative and non-sedative drugs...
March 2024: Clinical Toxicology
#16
MULTICENTER STUDY
Alicia Pérez-Blanco, María Acevedo, María Padilla, Aroa Gómez, Luis Zapata, María Barber, Adolfo Martínez, Verónica Calleja, María C Rivero, Esperanza Fernández, Julio Velasco, Eva M Flores, Brígida Quindós, Sergio T Rodríguez, Beatriz Virgós, Juan C Robles, Agustín C Nebra, José Moya, Josep Trenado, Nieves García, Ana Vallejo, Eugenio Herrero, Álvaro García, Maria L Rodríguez, Fernando García, Ramón Lara, Lucas Lage, Francisco J Gil, Francisco J Guerrero, Ángela Meilán, Nayade Del Prado, Cristina Fernández, Elisabeth Coll, Beatriz Domínguez-Gil
Intensive Care to facilitate Organ Donation (ICOD) consists of the initiation or continuation of intensive care measures in patients with a devastating brain injury (DBI) in whom curative treatment is deemed futile and death by neurological criteria (DNC) is foreseen, to incorporate organ donation into their end-of-life plans. In this study we evaluate the outcomes of patients subject to ICOD and identify radiological and clinical factors associated with progression to DNC. In this first prospective multicenter study we tested by multivariate regression the association of clinical and radiological severity features with progression to DNC...
2024: Transplant International
#17
JOURNAL ARTICLE
Nicolas Weiss, Simona Tripon, Maxime Mallet, Françoise Imbert-Bismut, Mehdi Sakka, Dominique Bonnefont-Rousselot, Philippe Sultanik, Sarah Mouri, Marika Rudler, Dominique Thabut
BACKGROUND: Hepatic encephalopathy (HE) is highly prevalent in patients with liver diseases. The pathophysiology of HE is centered on the synergic role of hyperammonemia and systemic inflammation. However, some data suggest altered functioning of the blood-brain barrier (BBB). Assessing BBB function is challenging in clinical practice and at the bedside. Protein-S-100 Beta (PS100-Beta) could be a useful peripheral marker of BBB permeability in HE. This study aimed to assess plasmatic PS100-Beta levels in a prospective cohort of patients admitted to the intensive care unit (ICU) with decompensated cirrhosis with and without overt HE...
April 2024: J Intensive Med
#18
Ghanishtha C Burile, Raghumahanti Raghuveer, Vaibhav Chandankhede, Shrushti Jachak, Neha Arya
Glioblastoma is the most prevalent primary brain tumor. Because glioblastomas are very vascular, they may worsen the disease's neurologic symptoms by causing vasogenic brain edema and mass effects with a wide range of other symptoms. In this case report, a 42-year-old male complaining of severe headache, generalized weakness, and forgetfulness was brought to a territory care hospital, where a detailed neurological examination and investigations with magnetic resonance imaging (MRI) revealed a grade IV (high-grade) glioma at the right frontotemporal and capsuloganglionic regions of the brain, and was suggested for surgery...
March 2024: Curēus
#19
JOURNAL ARTICLE
Erica Alves Ferreira Gordillo, Rubia Laine de Paula Andrade, Ismael Hoare, Ricardo Izurieta, Adriana Zilly, Laiz Mangini Cicchelero, Merielly Kunkel, Ernesto Valdes Gordillo, Reinaldo Antonio Silva-Sobrinho, Regiane Bezerra Campos, Rosane Meire Munhak Silva
INTRODUCTION: The severity of COVID-19 in the general population ranges from minimally symptomatic disease to critical illness, which may require hospitalization and progress to death. METHODS: A retrospective cohort study carried out with all positive cases of COVID-19 reported in the municipality of Foz do Iguaçu (PR) between the period from March 2020 to December 2021. Data were collected from Bank Notifies COVID-19 is the name of the information system that provides notifications by professionals of suspected and confirmed cases of the disease...
2024: Journal of Global Infectious Diseases
#20
REVIEW
Lorenzo Barba, Carmelo Carrubba, Kai Spindler, Christopher M Weise, Torben Sachs, Matteo Foschi, Lucio D'Anna, Bernhard Sehm, Richard Ibe, Erck Elolf, Christian Strauss, Markus Otto, Alexander Mensch, Samir Abu-Rumeileh
Posterior reversible encephalopathy syndrome (PRES) is an acute neurological condition associated with different etiologies, including antibiotic therapy. To date, most data regarding antibiotic-related PRES are limited to case reports and small case series. Here, we report a novel case description and provide a systematic review of the clinico-radiological characteristics and prognosis of available cases of PRES associated with antibiotic therapy. We performed a systematic literature search in PubMed and Scopus from inception to 10 January 2024, following PRISMA guidelines and a predefined protocol...
April 29, 2024: Neurological Sciences
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