Shabir Hassan, Ting Wang, Kun Shi, Yike Huang, Maria Elizabeth Urbina Lopez, Kaifeng Gan, Mo Chen, Niels Willemen, Haroon Kalam, Eder Luna-Ceron, Berivan Cecen, Gihan Daw Elbait, Jinghang Li, Luis Enrique Garcia-Rivera, Melvin Gurian, Mudassir Meraj Banday, Kisuk Yang, Myung Chul Lee, Weida Zhuang, Castro Johnbosco, Oju Jeon, Eben Alsberg, Jeroen Leijten, Su Ryon Shin
Oxygenating biomaterials can alleviate anoxic stress, stimulate vascularization, and improve engraftment of cellularized implants. However, the effects of oxygen-generating materials on tissue formation have remained largely unknown. Here, we investigate the impact of calcium peroxide (CPO)-based oxygen-generating microparticles (OMPs) on the osteogenic fate of human mesenchymal stem cells (hMSCs) under a severely oxygen deficient microenvironment. To this end, CPO is microencapsulated in polycaprolactone to generate OMPs with prolonged oxygen release...
May 31, 2023: Biomaterials