Alexandre Girard, Sinmanus Vimonpatranon, Amanda Chan, Andrew Jiang, Da Wei Huang, Kimmo Virtaneva, Kishore Kanakabandi, Craig Martens, Livia R Goes, Marcelo Soares, Isabella Licavoli, Jordan McMurry, Pearl Doan, Samuel Wertz, Danlan Wei, Donald Van Ryk, Sundar Ganesan, Il Young Hwang, John H Kehrl, Elena Martinelli, James Arthos, Claudia Cicala
Resident memory T cells (TRM s) help control local immune homeostasis and contribute to tissue protective immune responses. The local cues that guide their differentiation and localization are poorly defined. We demonstrate that MAdCAM-1, a ligand for the gut homing receptor α4 β7 integrin, in the presence of retinoic acid and TGF-β provide a costimulatory signal that induces blood CD8+ T cells to adopt a TRM -like phenotype. These cells express CD103 (integrin αE ) and CD69, the two major TRM cell surface markers, along with CD101...
May 8, 2024: Mucosal Immunology