Giacomo M Butta, Giorgio Bozzi, Greta Gallo, Gaia Copaloni, Chiara Cordiglieri, Mariacristina Crosti, Marilena Mancino, Daniele Prati, Viviana Simon, Andrea Gori, Alessandra Bandera, Raffaele De Francesco, Lara Manganaro
HIV integrates into the host genome, creating a viral reservoir of latently infected cells that persists despite effective antiretroviral treatment. CD4-positive (CD4+ ) T cells are the main contributors to the HIV reservoir. CD4+ T cells are a heterogeneous population, and the mechanisms of latency establishment in the different subsets, as well as their contribution to the reservoir, are still unclear. In this study, we analyzed HIV latency establishment in different CD4+ T cell subsets stimulated with interleukin 15 (IL-15), a cytokine that increases both susceptibility to infection and reactivation from latency...
May 2, 2022: Journal of Virology